National Facility for Translational Medicine (Shanghai), Shanghai Sixth People's Hospital Branch stands as a premier research institution, devoted to deepening our comprehension of the intricate interplay between metabolism and disease. Central to the facility's mission is pioneering the development of innovative methodologies for comprehensive profiling of endogenous small-molecule metabolites and trace elements across diverse biological samples, including blood, urine, saliva, cell lysates, and tissues from both experimental models and human subjects. This approach empowers the facility to probe the molecular mechanisms driving disease pathogenesis and progression.

National Facility for Translational Medicine (Shanghai), Shanghai Sixth People's Hospital Branch focuses on three core domains:

1. Unbiased Metabolic Profiling and Data Mining: Employing cutting-edge techniques, the facility conducts exhaustive metabolic profiling and data mining, facilitating the identification, annotation, and interpretation of metabolites and their biological significance. This approach serves as a potent tool for unraveling the molecular underpinnings of disease pathogenesis and progression.
2. Disease Phenotype Classification and Prediction: Harnessing distinctive metabolic signatures, the facility adeptly classifies and predicts disease phenotypes with remarkable accuracy. Integrating artificial intelligence and big data mining methodologies enables precise patient stratification and personalized treatment strategies, with the overarching objective of enhancing patient outcomes and alleviating the burden of disease.
3. Microbial Metabolome and Host-Gut Microbe Interactions: The facility is steadfast in advancing our comprehension of the pivotal role played by the microbial metabolome and host-gut microbe interactions in shaping gastrointestinal diseases and metabolic disorders. Through exploration of the therapeutic potential inherent in small molecule compounds, natural products, and traditional Chinese medicines, the facility endeavors to pioneer effective interventions for these conditions.

The facility's unwavering dedication to excellence, coupled with its commitment to cutting-edge research and interdisciplinary collaboration, has yielded groundbreaking discoveries poised to revolutionize the diagnosis, treatment, and prevention of a myriad of diseases. Notably, the facility's research team spearheads various scientific endeavors, including initiatives backed by the Ministry of Science and Technology's 973 Program and National Natural Science Foundation of China (NSFC) international cooperation projects. Their research findings, published in prestigious journals such as Cell Metabolism, Cancer Cell, Science Translational Medicine, Nature Communications, Nature Reviews Drug Discovery, and Nature Reviews Gastroenterology & Hepatology, have garnered recognition as one of the world's top ten scientific breakthroughs in the domain of "Your Microbes, Your Health" by SCIENCE. Furthermore, the facility has been bestowed with the second prize of the Natural Science Award from the Shanghai Science and Technology Commission, affirming its distinguished contributions to scientific advancement.