Research
Search
Close
CHEN Xiaohua
- Chief Physician, Doctoral Supervisor, Professor, Researcher
- Department: Infectious Diseases
- Research Area: Internal Medicine (Infectious Diseases)
- Research Interests: Pathogenesis of viral hepatitis
- Contact: chenxiaohua2000@163.com
- Visiting Scholar, Stanford University, Gastroenterology, 2014-2015
- MD from Shanghai Jiao Tong University School of Medicine, 2009
- Associate Director, Department of Infectious Diseases, Shanghai Sixth People's Hospital;
- Vice Chairman of the Infectious Disease Branch of Shanghai Medical Association;
- Member of the Virology Branch of Shanghai Medical Association
- Mengjiao Lv, Ting Yao, Yi Zhang, Siyuan Ma, Jinmei Chen, Zhenghao Tang, Guoqing Zang#, Xiaohua Chen#. Exosomes loading Tapasin enhance T cell immune response by autophagy to inhibit HBV replication. Journal of Medical Virology. 2023 Apr; 95(4): e28746. doi: 10.1002/jmv.28746.
- Siyuan Ma, Mengjiao Lv, Xiaohua Chen#, Guoqing Zang, Zhenghao Tang, Yi Zhang, Weiwei Hu. Avasimibe can cooperate with a DC-targeting and integration-deficient lentivector to induce stronger HBV specific T cytotoxic response by regulating cholesterol metabolism. Antiviral Res. 2023 Jun 29; 216:105662. doi: 10.1016/j.antiviral.2023.105662.
- Ting Yao, Mengjiao Lv, Siyuan Ma, Jinmei Chen, Yi Zhang, Yongsheng Yu, Guoqing Zang, Xiaohua Chen#. Ubiquitinated Hepatitis D Antigen-Loaded Microvesicles Induce a Potent Specific Cellular Immune Response to Inhibit HDV Replication in Vivo. Microbiology Spectrum. 2021 Dec 22; 9(3): e0102421. doi: 10.1128/Spectrum.01024-21.
- Yi Zhang, Jinmei Chen, Xiaoli Yi, Zhiheng Chen, Ting Yao, Zhenghao Tang, Guoqing Zang, Xuejie Cao, Xiao-Feng Lian, Xiaohua Chen#. Evaluation of the metagenomic next-generation sequencing performance in pathogenic detection in patients with spinal infection. Frontiers in Cellular and Infection Microbiology. 2022 Oct 27; 12: 967584. doi: 10.3389/fcimb.2022.967584.
- Jingwen Ai, Yi Zhang, Haocheng Zhang, Qiran Zhang, Zhangfan Fu, Ke Lin, Jieyu Song, Yuanhan Zhao, Mingxiang Fan, Hongyu Wang, Yang Zhou, Xiaohua Chen#, Chao Qiu, Wenhong Zhang. Safety and immunogenicity of a third-dose homologous BBIBP-CorV boosting vaccination: interim results from a prospective open-label study. Emerg Microbes Infect. 2022 Dec;11(1):639-647. doi: 10.1080/22221751.2022.2025746.
- Xiaohua Chen#, Hongyu Wang, Jingwen Ai, Leer Shen, Lin Ke, Guanmin Yuan, Xiaohua Sheng, Xia Jin, Zhifeng Deng, Jie Xu, Guanzhu Lu, Shujie Chen, Jianpeng Cai, Yi Zhang, Haocheng Zhang, Sen Wang, Wenhong Zhang, Cunyi Fan. Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-center cohort study. Emerg Microbes Infect.2022 Dec;11(1):2501-2509. doi: 10.1080/22221751.2022.2122581.
- Wu S, Zhang Y, Tang Y, Yao T, Lv M, Tang Z, Zang G, Yu Y, Chen X#. Molecular epidemiology and clinical characteristics of hepatitis delta virus (HDV) infected patients with elevated transaminases in Shanghai, China. BMC Infect Dis. 2020 Aug 3;20(1):565. doi: 10.1186/s12879-020-05275-1.
- Zhang Y, Tao R, Wu SS, Xu CC, Wang JL, Chen J, Yu YS, Tang ZH, Chen XH#, Zang GQ. TRIM52 up-regulation in hepatocellular carcinoma cells promotes proliferation, migration and invasion through the ubiquitination of PPM1A. J Exp Clin Cancer Res. 2018 Jun 13;37(1):116. doi: 10.1186/s13046-018-0780-9.
- Chen X#, Oidovsambuu O, Liu P, Grosely R, Elazar M, Winn VD, Fram B, Boa Z, Dai H, Dashtseren B, Yagaanbuyant D, Genden Z, Dashdorj N, Bungert A, Dashdorj N, Glenn JS. A novel quantitative microarray antibody capture assay identifies an extremely high hepatitis delta virus prevalence among hepatitis B virus-infected mongolians. Hepatology. 2017;66(6):1739-1749. doi: 10.1002/hep.28957.
- Dongling Shi, Jie Chen, Meng Zhao, Yuanjia Tang, Chen Zhao, Yinpeng Jin, Di Tian, Yixin Liao, Xuebi Wang, Wei Wang, Xiaohong Fan, Zhigang Yi#, Xiaohua Chen#, Yun Ling#. Prevalence of Neutralizing Autoantibodies against Type I Interferon in a Multicenter Cohort of Severe or Critical COVID-19 Cases in Shanghai. Journal of Clinical Immunology. 2024. 44:80. DOI: 10.1007/s10875-024-01683-z.
