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CHEN Suzhen  

  • Doctoral Supervisor, Associate Researcher
  • Department: Endocrinology and Metabolism
  • Research Area: Internal Medicine (Endocrinology and Metabolism)
  • Research Interests: Pathogenesis of obesity and diabetes
  • Contact: cszdream@163.com
Biography Positions Publications Patents
  • PhD from Fudan University, 2016
  • BM from Fudan University, 2011
  • Associate Researcher, Shanghai Diabetes Institute, Shanghai Sixth People's Hospital
  • Young Committee Member of the Metabolic Biology Branch, Chinese Society of Biophysics
  • Young Committee Member and Secretary of the Medical Genetics Branch, Shanghai Medical Association
  • Young Committee Member of the Metabolism Specialty Branch, Chinese Society of Biochemistry and Molecular Biology
  1. Suzhen Chen*#; Xiaoxiao Liu; Chao Peng; Chang Tan; Honglin Sun; He Liu; Yao Zhang; Ping Wu; Can Cui; Chuchu Liu; Di Yang; Zhiqiang Li; Junxi Lu; Jian Guan; Xisong Ke; Renxiao Wang; Xiaohai Bo; Xiaojun Xu#; Junfeng Han#; Junli Liu#; The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity, Cell Metabolism, 2021, 33(3): 565-580  DOI: 10.1016/j.cmet.2021.02.007
  2. Yao Zhang; Quanxin Jiang; Xingxing Liang; Qiqi Qian; Jie Xiong; Chuchu Liu; Junting Xu; Ning Wang; Ying Xu; Peihui Zhou; Sijia Lu; Qian Zhou; Yanmei Yuan; Xuemei Fan; Junli Liu#; Suzhen Chen#; Coagulation factor FVII fine-tunes hepatic steatosis by blocking AKT-CD36-mediated fatty acid uptake, Diabetes, 2024, 73(5)  DOI: 10.2337/db23-0814
  3. Honglin Sun; Gang Wei; He Liu; Danrui Xiao; Jianbo Huang; Junxi Lu; Ji Miao; Junli Liu#; Suzhen Chen#; Inhibition of XBP1s ubiquitination enhances its protein stability and improves glucose homeostasis, Metabolism-Clinical and Experimental, 2020, 105: 154046    DOI: 10.1016/j.metabol.2019.154046
  4. Chuchu Liu; Yao Zhang; Ning Wang; Junting Xu; Xingxing Liang; Jie Xiong; Sijia Lu; Peihui Zhou; Yanping Wang; Junli Liu#; Suzhen Chen#; Betaine–homocysteine methyltransferase promotes adipocyte commitment and insulin resistance via p38 MAPK/Smad signaling, Obesity, 2023, 31(6):1569-1583     DOI: 10.1002/oby.23737
  5. Yanping Wang; Jie Xiong; Yanmei Yuan; Chao Peng; Ping Wu; Yibing Wang; Junxi Lu; Yue Yin; Junting Xu; Suzhen Chen#; Junli Liu#; Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance, Obesity, 2022, 30(3): 680-693     doi: 10.1002/oby.23361.
  6. Quanxin Jiang; Ning Wang; Sijia Lu; Jie Xiong; Yanmei Yuan; Junli Liu#; Suzhen Chen#; Targeting hepatic ceruloplasmin mitigates nonalcoholic steatohepatitis by modulating bile acid metabolism, Journal of Molecular Cell Biology, 2023, mjad060   DOI: 10.1093/jmcb/mjad060
  7. Suzhen Chen; Liufang Ning; Xu Xu; Wenyan Jiang; Chun Xing; Weiping Jia; Xiaoli Chen; Qiqun Tang#; Haiyan Huang#; The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling, Cell Death and Differentiation, 2016, 23(11): 1778-1791   DOI: 10.1038/cdd.2016.66
  8. Suzhen Chen; Xu Xu; Liufang Ning; Wenyan Jiang; Chun Xing; Qiqun Tang; Haiyan Huang#; miR-27 impairs the adipogenic lineage commitment via targeting lysyl oxidase, Obesity, 2015, 23(12): 2445-2453    DOI: 10.1002/oby.21319
  9. Sijia Lu; Suzhen Chen#; Ji Miao#; Junli Liu#; Comments on ‘Downregulation of hepatic Ceruloplasmin ameliorates NAFLD via SCO1-AMPK-LKB1 complex’, Journal of Molecular Cell Biology, 2023, 15(4): mjad026   DOI: 10.1093/jmcb/mjad026
  10. Kun Zheng; Suzhen Chen#; Xiaoyong Hu#; Peroxisome proliferator-activated receptor gamma coactivator-1 alpha: A double-edged sword in prostate cancer, Current Cancer Drug Targets, 2022, 22(7): 541-559    DOI: 10.2174/1568009622666220330194149
  1. [Junli Liu, Min Zhang, Suzhen Chen] (2023), “Method for Constructing a Systemic EEPD1 Knockout Animal Model and Its Application”, ZL202110163327.0 
  2. [Suzhen Chen, Junli Liu, Yao Zhang, Quanxin Jiang] (2024), “Application of Agents that Promote or Activate F7 Gene Expression in the Preparation of Drugs for the Treatment and Prevention of NAFLD”, 202410083198.8
  3. [Junli Liu, Suzhen Chen, Peihui Zhou] (2023), “Application of Dlat Gene Expression Promoters or Agonists in the Preparation of Drugs for the Treatment of Diabetic Nephropathy”, 202310867198.2 
  4. [Junli Liu, Xiaoxiao Liu, Suzhen Chen, Honglin Sun, Jiangfeng Ke] (2018), “Use of Hypericin in the Preparation of Drugs that Promote White Fat Browning and Enhance Brown Fat Activity”, 201811198262.8 
  5. [Junli Liu, Suzhen Chen, Jie Xiong] (2024), “Application of Retigabine in the Preparation of Drugs for the Treatment of Non-alcoholic Fatty Liver Disease”, 202410128410.8 
  6. [Junli Liu, Suzhen Chen, Hanrui Yin, Ning Wang] (2023), “Drug composition and its use in the preparation of a drug for treating renal cancer”, 202310728854.0

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