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CHEN Lubin
- Graduate Supervisor, Associate Researcher
- Department: Anesthesiology
- Research Area: Anesthesiology
- Research Interests: Sodium channels and peripheral mechanisms of pain
- Contact: lubinchen@shsmu.edu.cn
- Associate Researcher, Department of Anesthesiology, Shanghai Sixth People's Hospital, 2021-2024
- Postdoc, Department of Neurology, Yale University School of Medicine, 2015-2020
- PhD from Cambridge University, 2014
- BSc from Shanghai Jiao Tong University, 2007
- Ana Paula Nascimento de Lima, Huiran Zhang, Lubin Chen, Philip R Effraim, Carolina Gomis-Perez, Xiaoyang Cheng, Jianying Huang, Stephen G Waxman, Sulayman D Dib-Hajj. Nav1.8 in small dorsal root ganglion neurons contributes to vincristine-induced mechanical allodynia. Brain, 2024, doi: 10.1093/brain/awae071.
- Chen L, Wimalasena NK, Shim J, Han C, Lee S, Gonzalez-Cano R, Dib-Hajj SG, Woolf CJ, and Waxman SG. Two independent mouse lines carrying the Nav1.7-I228M gain-of-function variant display DRG neuron hyperexcitability but a minimal pain phenotype. Pain, 2021, doi: 10.1097/j.pain.0000000000002171.
- Lubin Chen, Jianying Huang, Curtis Benson, Karen L Lankford, Peng Zhao, Jennifer Carrara, Andrew M Tan, Jeffery D Kocsis, Stephen G Waxman, Sulayman D Dib-Hajj. Sodium channel Nav1.6 in sensory neurons contributes to vincristine-induced allodynia. Brain, 2020, doi: 10.1093/brain/awaa208.
- Chen L, Effraim P, Carrara J, Zhao P, Dib-Hajj F, Dib-Hajj SD, Waxman SG. Pharmacological characterization of a rat Nav1.7 loss-of-function model with insensitivity to pain. Pain, 2020, doi: 10.1097/j.pain.0000000000001807.
- Grubinska B, Chen L, Alsaloum M, Rampal N, Matson DJ, Yang C, Taborn K, Zhang M, Youngblood B, Liu D, Galbreath E, Allred S, Lepherd M, Ferrando R, Kornecook TJ, Lehto SG, Waxman SG, Moyer BD, Dib-Hajj SD, Gingras J. Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers. Molecular Pain, 2019, doi: 10.1177/1744806919881846.
- Chen L, Huang J, Zhao P, Persson AK, Dib-Hajj FB, Cheng X, Tan A, Waxman SG, Dib-Hajj SD. Conditional knockout of Nav1.6 in adult mice ameliorates neuropathic pain. Scientific Reports, 2018, doi: 10.1038/s41598-018-22216-w.
- Yang Y, Adi T, Effraim PR, Chen L, Dib-Hajj SD, Waxman SG. Reverse pharmacogenomics: carbamazepine normalizes activation and attenuates thermal hyperexcitability of sensory neurons due to Nav1.7 mutation I234T. British Journal of Pharmacology, 2018, doi: 10.1111/bph.13935.
