Research
Search
Close
CHANG Chunkang
- Doctoral Supervisor, Professor
- Department: Hematology
- Research Area: Internal Medicine (Hematology)
- Research Interests: Pathogenesis of myelodysplastic syndrome
- Contact: changchunkang7010@aliyun.com
- MD from Second Military Medical University, 2011
- Master from Fudan University, 2004
- Director, Department of Hematology, Shanghai Sixth People's Hospital
- Zhao Y, Guo J, Zhao S, Wang R, Shi L, Fang Y, Zhang Z, Song L, Wu D, Chang C#. Bone Marrow Fibrosis at Diagnosis and during the Course of Disease Is Associated with TP53 Mutations and Adverse Prognosis in Primary Myelodysplastic Syndrome. Cancers (Basel). 2022 Jun 16;14(12):2984.
- Chang CK#, Zhao YS, Xu F, Guo J, Zhang Z, He Q, Wu D, Wu LY, Su JY, Song LX, Xiao C, Li X.TP53 mutations predict decitabine-induced complete responses in patients with myelodysplastic syndromes, Br J Haematol,2017, 176:600-608.
- Zheng Q, Zhao Y, Guo J, Zhao S, Fei C, Xiao C, Wu D, Wu L, Li X, Chang C#. Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK/MFF/Drp1 pathway. Cell Death Dis. 2018 May 1;9(5):515.
- Guo J, Zhao Y, Fei C, Zhao S, Zheng Q, Su J, Wu D, Li X, Chang C#. Dicer1 downregulation by multiple myeloma cells promotes the senescence and tumor-supporting capacity and decreases the differentiation potential of mesenchymal stem cells. Cell Death Dis. 2018 May 1;9(5):512.
- Xu F, Wu LY, Chang CK#, He Q, Zhang Z, Liu L, Shi WH, Guo J, Zhu Y, Zhao YS, Gu SC, Fei CM, Wu D, Zhou LY, Su JY, Song LX, Xiao C, Li X.Whole-exome and targeted sequencing identify ROBO1 and ROBO2 mutations as progression-related drivers in myelodysplastic syndromes.Nat Commun. 2015 Nov 26;6:8806.
- Zhao Y, Wu D, Fei C, Guo J, Gu S, Zhu Y, Xu F, Zhang Z, Wu L, Li X, Chang C#. Downregulation of Dicer1 promotes cellular senescence and decreases the differentiation and stem cell-supporting capacities of mesenchymal stromal cells in patients with myelodysplastic syndrome. Haematologica. 2015 Feb;100(2):194-204.
- 01/01/2024-12/31/2027
National Natural Science Foundation of China, ¥600,000, Study on mechanism of erythroid differentiation of MDS mediated by SETD2 via Uba5 in bone marrow mesenchymal stem cell.
Role: Principal Investigator - 01/01/2021-12/31/2024
National Key Research and Development Project, ¥560,000, S100A9 mediates the bone marrow microenvironment PD-1/PD-L1 signal to participate in the immune escape mechanism of MDS
Role: Project leader
