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GUO Yuanyuan
- Associate Professor, Graduate Supervisor
- Department: Radiology
- Research Area: Imaging and nuclear medicine
- Research Interests: Diagnosis and treatment of cardiovascular and cerebrovascular diseases and cancers; Molecular imaging;
- Contact: guoyuanyuanlel@163.com
- PhD from Shanghai Jiao Tong University, 2020
- Master's degree from Shandong University, 2016
- Bachelor's degree from Shandong University, 2013
- Associate Professor, Department of Radiology, Shanghai Sixth People’s Hospital
- Yuanyuan Guo; Fujun Wang; Sunli Wan; Xinhua Liu; Yu Huang; Miao Xie; Xiaoer Wei; Wangshu Zhu; Yuehua Li; Chuan Zhang; Yueqi Zhu. Endothelium-targeted NF-κB siRNA nanogel for magnetic resonance imaging and visualized-anti-inflammation treatment of atherosclerosis; Biomaterials, 2025, 314, 122897.
- Yuanyuan Guo; Qiushuang Zhang; Qiwen Zhu; Jing Gao; Xinyuan Zhu; Yaping Li; Yuehua Li; Chuan Zhang. Copackaging photosensitizer and PD-L1 siRNA in a nucleic acid nanogel for synergistic cancer photoimmunotherapy; Science Advances, 2022, 16(8), eabn2941.
- Yuanyuan Guo; Jingcan Qin; Qianqian Zhao; Jiapei Yang; Xiaoer Wei; Yu Huang; Miao Xie; Chuan Zhang; Yuehua Li. Plaque-Targeted Rapamycin Spherical Nucleic Acids for Synergistic Atherosclerosis Treatment; Advanced Science, 2022, 16, e2105875.
- Fujun Wang; Miao Xie; yang Huang; Yuhe Liu; Xinlong Liu; Lijuan Zhu; Xinyuan Zhu; Yuanyuan Guo*; Chuan Zhang. In Situ Vaccination with An Injectable Nucleic Acid Hydrogel for Synergistic Cancer Immunotherapy; Angewandte Chemie International Edition, 2024, 63(4):e202315282.
- Yuanyuan Guo; Jiao Zhang; Fei Ding; Gaifang Pan; Jing Li; Jing Feng; Xinyuan Zhu; Chuan Zhang. Stressing the Role of DNA as Drug Carrier: Synthesis of the DNA-Drug Conjugates through Grafting Chemotherapeutics onto Phosphorothioate Oligonucleotides; Advanced Materials, 2019, 31, 1807533.
- Yuanyuan, Guo; Jiao, Zhang; Gaifang, Pan; Chung Hang Jonathan, Choi; Ping, Wang; Yuehua, Li; Xinyuan, Zhu; Chuan, Zhang. Grafting multi-maleimides on antisense oligonucleotide to enhance its cellular uptake and gene silencing capability; Chemical Communications, 2020, 54(56), 7439-7442.
- Yu Huang; Jiahua Wang; Yuanyuan Guo; Lingyue Shen; Yuehua Li. Fibrinogen binding to activated platelets and its biomimetic thrombus-targeted thrombolytic strategies; International Journal of Biological Macromolecules, 2024, 274, 122386.
- Qianqian Zhao; Jingcan Qin; Fei Kong; Dongya Wang; Yuanyuan Guo*; Yuehua Li. A Novel Red-Emission Fluorescent Probe for the Detection of Cysteine in Vitro and in Vivo; Journal of Photochemistry and Photobiology A-chemistry; 2023, 436, 114383.
- Guo, Yuanyuan; He, Wenxiu; Yang, Shengfeng; Zhao, Dujuan; Li, Zhonghao; Luan, Yuxia. Co-delivery of docetaxel and verapamil by reduction-sensitive PEG-PLGA-SS-DTX conjugate micelles to reverse the multi-drug resistance of breast cancer. Colloids and Surfaces B: Biointerfaces; 2017, 151, 119-127.
- Guo Yuanyuan; Zhang Pei; Zhao Qingyun; Wang Kaiming; Luan Yuxia. Reduction-Sensitive Polymeric Micelles Based on Docetaxel-Polymer Conjugates Via Disulfide Linker for Efficient Cancer Therapy. Macromolecular Bioscience, 2016, 16, 420-431.
- 01/01/2025-12/31/2028
National Natural Science Foundation of China , ¥5,00,000, 8247072975,
1H/19F Dual-Nuclear MR Nanocontrast for RNA Imaging and High-Risk
Plaque Assessment
Role: Project leader - 01/01/2021-12/31/2024
National Natural Science Foundation of China , ¥3,00,000, 52103265,
Plaque targeting siRNA drug delivery system for anti-inflammatory
treatment of atherosclerosis
Role: Project leader - 03/01/2023-03/01/2026
Natural Science Foundation of Shanghai, ¥2,00,000, 23ZR1448000,
19F-MR nanoflare for M1-macrophages responsive imaing and treatment of atherosclerosis - 04/01/2021-03/31/2024
Shanghai Sailing Program, ¥2,00,000, 21YF1434300,
Phosphorothioate nucleic acid drug delivery system for treatment and diagnosis of antherosclerosis
- Chuan Zhang, Jiao Zhang, Yuanyuan Guo, (2019), "Preparation and application of Nucleic acid-drug conjugate and Nucleic acid-drug delivery system", CN109568595A
- Chuan Zhang, Yushuang Ren, Yuanyuan Guo, (2020), "Preparation and application of Nucleic acid-platinum-based drug conjugate and drug delivery systems", CN111803517A
- Yuehua Li, Yuanyuan Guo, Tingting Yao, Qiang Zhang, Zhi Xiong, (2024) "Preparation and application of nucleic acid nanogel", CN2024113960934
