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CHEN Hongqi
- Graduate Supervisor, Associate Chief Physician
- Department: General Surgery
- Research Area: Gastrointestinal Surgery
- Research Interests: Pathogenesis and Intervention Strategies of Gastrointestinal Tumors
- Contact: hqchen08@163.com
- Associate Chief Physician, Gerneral Surgery, Shanghai Sixth People's Hosptial, 2020
- Visiting Scholar in UPMC, 2019
- MM and MD from Shanghai Jiao Tong University School of Medicine, 2011
- Secretary-General, Special Committee of Intestinal Microecology and Intestinal Bacterial Transplantation of China Association for Promotion of Health Science and Technology
- Sun XF, Zhou LS, Wang Y, Deng GL, Cao XR, Ke BW, Wu XQ, Gu YH, Cheng HB, Xu Q, Du QM, Chen HQ#, Sun Y#, Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer. Journal of Pharmaceutical Analysis. 2023,13(7):726-744. doi: 10.1016/j.jpha.2023.04.013.
- Gao J, Wu ZG, Zhao MX, Zhang R, Li MR, Sun DD, Cheng HB, Qi XJ, Shen YX, Xu Q, Chen HQ#, Chen DJ#, Sun Y#. Allosteric inhibition reveals SHP2-mediated tumor immunosuppression in colon cancer by single-cell transcriptomics. Acta Pharm Sin B. 2022;12(1):149-166. doi: 10.1016/j.apsb.2021.08.006.
- Wang BL, Wang Y, Sun XF, Deng GL, Huang W, Wu XX, Gu YH, Tian ZG, Fan ZM, Xu Q, Chen HQ#, Sun Y#. CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell. Journal for ImmunoTherapy of Cancer 2021;9(8):e003100. doi: 10.1136/jitc-2021-003100.
- Chen LJ*, Chen HQ*, Ye JJ, Ge Y, Wang HY, Dai EY, Ren JH, Liu WL, Ma CR, Ju SG, Guo ZS, Liu ZQ, Bartlett DL. Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation. Theranostics 2021; 11(14):6668-6681. doi: 10.7150/thno.56494.
- Ding CS, Shan ZZ, Li MC, Chen HQ#, Li XX#, Jin ZM#. Characterization of the fatty acid metabolism in colorectal cancer to guide clinical therapy. Mol Ther Oncolytics. 2021;20:532-544. doi: 10.1016/j.omto.2021.02.010.
- 04/01/2022-03/31/2025
Natural Science Foundation of Shanghai Municipal Science and Technology Commission General Project, ¥200,000, 22ZR1447400
Molecular mechanism of CXCR6+CD8+T cells participating in the process of colitis-cancer transformation by regulating the immune microenvironment.
Role: Principal Investigator
