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LU Jin
- Graduate Supervisor, Associate Chief Pharmacist
- Department: Pharmacy
- Research Area: Pharmacology
- Research Interests: Mechanisms of Drug Therapy and Efficacy Evaluation in Neurological Diseases
- Contact: lujinsysu@hotmail.com
- Postdoctoral Researcher, Harvard Medical School, Emergency Medicine (Neurosurgery), 2023-2024.
- PhD & MD from Shanghai Jiao Tong University, 2016.
- Visiting PhD Student, Stanford University, School of Medicine, 2014.
- Associate Chief Pharmacist, Department of Pharmacy, Shanghai Sixth People's Hospital.
- Member, Pharmacotherapy Committee of the Shanghai Pharmaceutical Association.
- Youth Member, Hospital Pharmacy Committee of the Shanghai Pharmaceutical Association.
- Youth Member, Therapeutic Drug Monitoring Committee of the Shanghai Pharmacological Society.
- Member, Psychopharmacology Group of the Shanghai Medical Association.
- Jin Lu#, Jiawei Zhang#, Xiuzhe Wang, Bo Xin, Jie Li, Quanjun Yang, Xingxia Li, Jianping,Zhang, Xingyan Wang, Jianliang Fu*, Cheng Guo* . Dl-3-n-butylphthalide promotes microglial phagocytosis and inhibits microglial inflammation via regulating AGE-RAGE pathway in APP/PS1 mice. Brain Research Bulletin. 2024 (212C):110969. DOI: 10.1016/j.brainresbull.2024.110969
- Jin Lu#, Xiuzhe Wang#, Lili Wan, Jianliang Fu,Yan Huo, Yuwu Zhao*, Cheng Guo*. Gene polymorphisms affecting the pharmacokinetics and pharmacodynamics of donepezil efficacy，Frontiers in Pharmacology, 2020;11:934.DOI: 10.3389/fphar.2020.00934
- Jin Lu，Jianliang Fu, Yuan Zhong,Quanjun Yang , Jinlu Huang , Jie Li ,Yan Huo , Yuwu Zhao, Lili Wan*, Cheng Guo*. Association between ABCA1 gene polymorphism and the response to donepezil therapy in Han Chinese patients with Alzheimer’s disease. Brain Research Bulletin 2018;140:1-4.DOI: 10.1016/j.brainresbull.2018.03.014
- Jin Lu #, Jianliang Fu#, Yuan Zhong,Pengguo Chen, Quanjun Yang, Yuwu Zhao, Lili Wan*,Cheng Guo*. The roles of apolipoprotein E3 and CYP2D6 (rs1065852) gene polymorphisms in the predictability of responses to individualized therapy with donepezil in Han Chinese patients with Alzheimer's disease. Neuroscience Letters, 2016,614: 43–48.DOI: 10.1016/j.neulet.2015.12.062
- Jin Lu #, Lili Wan#,Yuan Zhong,Qi Yu, Yonglong Han, Pengguo Chen, Beiyun Wang, Wei Li,Ya Miao, Cheng Guo*. Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer’s disease. Journal of Pharmacological Sciences, 2015,129(3):188-95.DOI: 10.1016/j.jphs.2015.10.010
- 01/01/2022-12/31/2024
National Natural Science Foundation of China , ¥300,000, 82104142
Mechanisms of Donepezil's Regulation of Cholesterol Metabolism in Alzheimer’s Disease
Role: Principal Investigator - 01/01/2020-12/31/2022
Shanghai Health Commission Clinical Research Project, ¥50,000, 20194Y0052
Personalized Medication for Valproic Acid in Low Albumin Hemodialysis Patients
Role: Principal Investigator - 01/01/2018-12/31/2021
Shanghai Jiao Tong University School of Medicine, Affiliated Sixth People's Hospital 2018 Annual Clinical Research Project, ¥100,000, YNLC201826,
Clinical Efficacy Study of Donepezil for Neuropsychiatric Symptoms Accompanying Mild Cognitive Impairment.
Role: Principal Investigator - 01/01/2018-12/31/2019
Shanghai Jiao Tong University School of Medicine, Hospital Pharmacy Research Project，¥10,000, JDYX2017QN012
Individualized Drug Use Study of Donepezil in Alzheimer’s Disease Based on Dominant Monomer Blood Drug Concentration Monitoring and Pharmacogenetic Testing.|
Role: Principal Investigator - 01/01/2018-12/31/2021
National Multicenter Clinical Research Projec，¥30,00,000.
Parkinson's Disease Multicenter Comprehensive Evaluation Guideline Project—Multicenter Real-World Comprehensive Evaluation of Clinical Medication in Parkinson's Disease .
Role: Subproject Leader - 01/01/2016-12/31/2019
Shanghai Jiao Tong University School of Medicine, Affiliated Sixth People's Hospital Scientific Research Project，¥30,000, YNLC201614
Preliminary Exploration of Pharmacokinetics/Pharmacodynamics Biomarkers for Donepezil,.
Role: Principal Investigator - 01/01/2013-12/31/2015
National Natural Science Foundation of China , ¥230,000, 81202599
Study on the Stereoselective Metabolism and Transport Mechanisms of Donepezil and Related Candidate Genes
Role: Principal Participant
- [Lu Jin, Guo Cheng, Fu Jianliang, Zhang Jiawei](2023). Application of the AGE-RAGE Pathway in the Prevention and/or Treatment of Alzheimer's Disease, CN 202310367704.1.
- [Chen Yan, Huang Weifeng, Mao Changqing, Yang Li, Lu Jin](2023). A Fall-Resistant Sampling Tube.ZL202321714764.8.
