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LIU Xiaonan  

  • Doctoral Supervisor, Professor
  • Department: Orthopedics
  • Research Area: Bone metabolism and disorder, Bone aging, Senescent cell
  • Research Interests: Pathogenesis of degenerative bone diseases
  • Contact: liu_liuxn@qq.com
Biography Positions Publications Research Projects
  • Residency, Deparment of Orthopedics (National Center for Orthopedics), Shanghai Sixth People's Hospital, 2023-Now
  • Postdoc at Johns Hopkins University School of Medicine (Mentor: Prof. Xu Cao; Prof. Mei Wan), 2020-2023
  • M.D. from Southern Medical University School of Medicine (Mentor: Prof. Bin Yu), 2016-2019 
  • Bachelor of Medicine from Southern Medical University School of Medicine, 2011-2016
  • Fellowship, the International Chinese Musculoskeletal Research society (ICMRS)  
  • Fellowship, the American Society of Bone and Mineral Research (ASBMR)                                
  • Commissioner, the China Association of Gerontology and Geriatrics, Orthopedic Branch (CAGG)  
  1. Liu, X., Gu, Y., Kumar, S., Amin, S., Guo, Q., Wang, J., Fang, C., Cao, X., and Wan, M. Adipocyte Senescence Initiated by Oxylipin-PPARγ Loop Propagates a Secondary Senescence in Bone Marrow. CELL METABOLISM (2023) 35(4): 667-684.
  2. Liu, X., Chai, Y., Liu, G., Su, W., Guo, Q., Lv, X., Gao, P., Yu, B., Ferbeyre, G., Cao, X., & Wan, M. GSK-J4 Alleviates Glucocorticoid-Induced Bone Loss and Growth Retardation by Targeting Cellular Senescence. BONE RESEARCH (2021) (Accepted) 
  3. Liu, X., Chai, Y., Liu, G., Su, W., Guo, Q., Lv, X., Gao, P., Yu, B., Ferbeyre, G., Cao, X., & Wan, M. (2021). Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis. NATURE COMMUNICATIONS, 12(1) http://doi.org/10.1038/s41467-021-22131-1
  4. Liu, X. (2021). Serum and Synovial Biomarkers for the Diagnosis of Implant-Associated Infection After Orthopedic Surgery. ORTHOPEDICS (Thorofare, N.J.), 1-9. http://doi.org/10.3928/01477447-20210104-07
  5. Hu, B., Lv, X., Chen, H., Xue, P., Gao, B., Wang, X., Zhen, G., Crane, J. L., Pan, D., Liu, S., Ni, S., Wu, P., Su, W., Liu, X., Ling, Z., Yang, M., Deng, R., Li, Y., Wang, L., Zhang, Y., Wan, M., Shao, Z., Chen, H., Yuan, W., & Cao, X. (2020). Sensory nerves regulate mesenchymal stromal cell lineage commitment by tuning sympathetic tones. JOURNAL OF CLINICAL INVESTIGATION, 130(7), 3483-3498. http://doi.org/10.1172/JCI131554
  6. Liu, X., Zhang, F., Chai, Y., Wang, L., & Yu, B. (2020). The role of bone-derived PDGF-AA in age-related pancreatic β cell proliferation and function. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS http://doi.org/10.1016/j.bbrc.2019.12.057
  7. Liu, X., & Wan, M. (2019). A tale of the good and bad: Cell senescence in bone homeostasis and disease [Journal Article]. INT REV CELL MOL BIOL, 346, 97-128. http://doi.org/10.1016/bs.ircmb.2019.03.005
  8. Miao, Y., Qu, Q., Jiang, W., Liu, F., Liu, X., Liu, X., Liu, Y., Liu, Y., Shi, P., Fan, Z., Du, L., Wang, G., Guo, Z., & Hu, Z. (2018). Identification of Functional Patterns of Androgenetic Alopecia Using Transcriptome Profiling in Distinct Locations of Hair Follicles. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 138(4), 972-975. http://doi.org/10.1016/j.jid.2017.10.027
  9. Qu, Q., Zeng, F., Liu, X., Wang, Q. J., & Deng, F. (2016). Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer. CELL DEATH& DSEASE, 7(5), e2226. http://doi.org/10.1038/cddis.2016.132
  10. Rindone, A. N., Liu, X., Farhat, S., Perdomo-Pantoja, A., Witham, T. F., Coutu, D. L., Wan, M., & Grayson, W. L. (2021). Quantitative 3D imaging of the cranial microvascular environment at single-cell  resolution [Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.]. NATURE COMMUNICATIONS, 12(1), 6219. http://doi.org/10.1038/s41467-021-26455-w
  • 01/01/2025-12/31/2028
    National Natural Science Foundation of China (Excellent Young Scientist Program), ¥100,0000, 2024-24610415143159431
    Mechanisms of Osteoporosis and Precision Treatment                                                                   
    Role: Principal Investigator
  • 01/01/2024-12/31/2026
    National Natural Science Foundation of China (Youth Program), ¥30,0000, 2023-82302740
    The mechanism of treatments targeting subchondral bone senescent cells and their IL-6 secretory phenotype in osteoarthritis
    Role: Principal Investigator

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