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LAI Ke
- Doctoral Supervisor, Researcher
- Department: ENT & HN Surgery
- Research Area: Central auditory and balance perception
- Research Interests: Disease mechanisms and antagonistic strategies related to central auditory and balance perception
- Contact: ilaike@alumni.sjtu.edu.cn
- Postdoc, Otolaryngology & Head and Neck Surgery, Shanghai Sixth People's Hospital, 2024
- PhD from Shanghai Jiao Tong University School of Medicine, 2020
- MPH from Nanchang University, 2014
- Resident Physician, Department of ENT & HN Surgery, Shanghai Sixth People's Hospital
- Gong LN, Liu HW, Lai K, Zhang Z, Mao LF, Liu ZQ, Li MX, Yin XL, Liang M, Shi HB, Wang LY, Yin SK. Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain. J Neurosci. 2024 Sep 23:e0442242024. doi: 10.1523/JNEUROSCI.0442-24.2024. Epub ahead of print. PMID: 39313321.
- Ke Lai#, Iva Pritišanac, Zhen-Qi Liu#, Han-Wei Lui, Li-Na Gong, Ming-Xian Li, Jian-Fei Lu, Xin Qi, Tian-Le Xu, Julie Forman-Kay, Hai-Bo Shi*, Lu-Yang Wang*, Shan-Kai Yin*, Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury. Nature. 2024，July 10;631(8022):826-834
- Kun Ni#, Hanwei Liu#, Ke Lai#, Li Shen, Xiaoyan Li*, Jiping Wang*, Haibo Shi*, Upregulation of A-type potassium channels suppresses neuronal excitability in hypoxic neonatal mice. FEBS J. 2023 Aug; 290 (16):4092-4106
- Han-Wei Liu#, Li-Na Gong#, Ke Lai#, Xia-Fei Yu, Zhen-Qi Liu, Ming-Xian Li, Xin-Lu Yin, Min Liang, Hao-Song Shi, Lin-Hua Jiang, Wei Yang, Hai-Bo Shi*, Lu-Yang Wang*, Shan-Kai Yin*, Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage. Neuron. 2023, May 17;111(10):1609-1625
- Li, Mingxian#, Liu Zhenqi#, Lai, Ke#, Liu Hanwei, Gong Lina, Shi Haosong, Zhang Weitian*, Wang Hui*, Shi Haibo*. Enhanced recruitment of glutamate receptors underlies excitotoxicity of mitral cells in acute hyperammonemia. Frontiers in Cellular Neuroscience. 2022 Oct 28;16:100267.
- 6Ke Lai#, Xing-Lei Song#, Hao-Song Shi#, Xin Qi, Chun-Yan Li, Jia Fang, Fan Wang, Oleksandr Maximyuk, Oleg Krishtal, Tian-Le Xu, Xiao-Yan Li, Kun Ni, Wan-Peng Li, Hai-Bo Shi*, Lu-Yang Wang*, Shan-Kai Yin*. Bilirubin enhances the activity of ASIC channels to exacerbate neurotoxicity in neonatal hyperbilirubinemia in mice. Science Translational Medicine. 2020 Feb 12;12(530):eaax1337
- Shi HS#, Lai K#, Yin XL, Liang M, Ye HB, Shi HB*, Wang LY*, Yin SK*. Ca2+-dependent recruitment of voltage-gated sodium channels underlies bilirubin-induced overexcitation and neurotoxicity. Cell Death & Disease. 2019 Oct 10;10(10):774
- 01/01/2022-12/31/2023
National Natural Science Foundation of China, ¥ 200,000; 82101234
Glutamate and ASICs mediate hypoxia-induced vestibular center damage through ionotype coupling.
Role: Project leader - 10/01/2021-09/3/2024
Youth Cultivation Project of Shanghai Sixth People's Hospital, ¥100,000, ynqn202108
The role and mechanism of acid-sensing ion channels in central nervous system injury caused by obstructive sleep apnea
Role: Project leader - 01/01/2021-12/31/2022
General project of China Postdoctoral Science Foundation,¥80,000, 2020M681335
Glutamate positive allosteric regulation of the protein structure and molecular mechanism of acid-sensing ion channels in ischemic brain injury
Role: Project leader
