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SHAO Rui
- Graduate Supervisor, Associate Researcher
- Department: Orthopedics
- Research Area: Bone and Cartilage
- Research Interests: Development and Injury Repair of Bone and Cartilage
- Contact: shaorui1030@163.com
- Associate Researcher, Department of Orthopedics, 2024
- Assistant Researcher, Department of Orthopedics, 2020
- PhD from University of Chinese Academy of Sciences, 2018
- Bachelor of Medical Laboratory Science from Wuhan University, 2012
- Associate Researcher, Institute of Microsurgery on Extremities, and Department of Orthopedics, Shanghai Sixth People's Hospital
- Rui Shao#, Jinlong Suo#, Zhong Zhang#, Mingxiang Kong, Yiyang Ma, Yang Wen, Mengxue Liu, Lenan Zhuang, Kai Ge, Qing Bi, Changqing Zhang*, Weiguo Zou*. H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis. Cell Death & Differentiation. 2024 Jan;31(1):106-118. doi: 10.1038/s41418-023-01244-8.
- Shanshan Li#, Rui Shao#, Shufa Li#, Jiao Zhao, Qi Deng, Ping Li, Zhanying Wei, Shuqin Xu, Lin Chen, Baojie Li, Weiguo Zou*, Zhenlin Zhang*. A loss-of-function variant CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. Bone Research. 2024. doi: 10.1038/s41413-024-00364-2.
- .Jinlong Suo#, Rui Shao#, Ruici Yang, Jinghui Wang, Zhong Zhang, Duo Wang, Ningning Niu*, Xianyou Zheng*, Weiguo Zou*. Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation. Cell Death & Disease. 2023 May 22;14(5):336. doi: 10.1038/s41419-023-05856-3.
- Rui Shao#, Zhong Zhang#, Zhan Xu, Huiling Ouyang, Lijun Wang, Hongwei Ouyang, Matthew Greenblatt, Xi Chen, Weiguo Zou*. H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Research. 2021 Jun 7;9(1):30. doi: 10.1038/s41413-021-00160-2.
- Rui Shao#, Jia Liu#, Guang Yan, Jinfang Zhang, Yujiao Han, Jianfeng Guo, Zhan Xu, Zhu Yuan, Jiankang Liu, Marcos Malumbres, Lixin Wan*, Wenyi Wei*, Weiguo Zou*. Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell Research. 2016 Jun;26(6):699-712. doi: 10.1038/cr.2016.51.
- Weiguo Zou#, Rui Shao, Dallas Jones*. Reply to 'Dissecting the role of miR-140 and its host gene'. Nature Cell Biology. 2018 May;20(5):519-520. doi: 10.1038/s41556-018-0076-5.
- Ningning Niu#, Rui Shao, Guang Yan, Weiguo Zou*. Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth. The Journal of Biological Chemistry. 2016 Dec 23;291(52):26647-26657. doi:10.1074/jbc.M116.749697.
- Lijun Wang#, Xiuling You#, Dengfeng Ruan#, Rui Shao, Hai-Qiang Dai, Weiliang Shen, Guo-Liang Xu, Wanlu Liu*, Weiguo Zou*. TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes. Nature Communications. 2022 Aug 11;13(1):4709. doi: 10.1038/s41467-022-32138-x.
- Jie Li#, Liansheng Zhang#, Yongwei Zheng, Rui Shao, Qianqian Liang, Weida Yu, Hongyan Wang, Weiguo Zou, Demin Wang, Jialing Xiang, Anning Lin*. BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages. Elife. 2020 Dec 3:9:e56309. doi: 10.7554/eLife.56309.
- Lijun Wang#, Ningning Niu#, Li Li#, Rui Shao, Huiling Ouyang, Weiguo Zou*. H3K36 trimethylation mediated by SETD2 regulates the fate of bone marrow mesenchymal stem cells. PLoS Biology. 2018 Nov 13;16(11):e2006522. doi:10.1371/journal.pbio.2006522.
- 01/01/2025-12/31/2028
National Natural Science Foundation of China (General Program), ¥490,000, 82472441
Mechanism study of H3K36 methylase NSD1 regulating the participation of resting state cartilage precursor cells in injury repair
Role: Project leader - 12/01/2022-11/30/2027
National Key R&D Program 'Stem Cell Research and Organ Repair', ¥5,000,000, 2022YFA1106800
Study on the role and functional regulation of mesenchymal stem cells in tissue and organ fibrosis
Role: Subject leader - 01/01/2020-12/31/2022
National Natural Science Foundation of China (Youth Program), ¥200,000, 81902212
Molecular Mechanism of Histone Methyltransferase NSD1 Regulating Bone Development and Fracture Repair
Role: Project leader - 11/01/2018-06/30/2020
National BoM General Program, ¥80,000, 2018M640431
Identification and investigation of the mechanism of action of key ions in cartilage metabolic homeostasis and osteoarthritis
Role: Project leader - 11/01/2018-06/30/2020
Shanghai Municipal Bureau of Human Resources and Social Affairs and Finance Bureau, Shanghai 'Super Postdoctoral' Talent Incentive Programme, ¥200,000, 2018145
Role: Project leader - 06/01/2018-06/30/2020
Ministry of Human Resources and Social Affairs and National Bo Management Committee (Postdoctoral Innovative Talent Support Programme), ¥600,000, BX20180337
Role: Project leader
