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ZHANG Xiaojie
- Associate Chief Physician, Graduate Supervisor
- Department: Neurology
- Research Area: Neurology
- Research Interests: Neurodegenerative disease; Amyotrophic lateral sclorosis; Noninvasive therapy; Neuroinflammation
- Contact: xjzzhang@sjtu.edu.cn
- Fellowship, National Institue on Aging, National Institute of Health, USA, 2024
- MD from Shanghai Jiao Tong University School of Medicine, 2005
- PhD from Shanghai Jiao Tong University School of Medicine, 2014
- Associate Chief Physician, Department of Neurology, Shanghai Sixth People's Hospital
- Member of Neuromyopathy and Electrophysiology Committee, Shanghai Medical Asscoiation
- Member of Neuro-rehabilitation Committee, Shanghai Association of Rehabilitation Medicine
- Member of Electroencephalography and Clinical Neurophysiology Committee, Shanghai Medical Asscoiation
- Liu ZH, Zhang H, Lu KL, Chen L, Zhang YQ, Xu ZW, Zhou HS, Sun JF, Xu MY, Ouyang Q, Cao L, Zhao YW, Jiang LX, Zheng YY*, Zhang XJ*. Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Cell Reports, 2024, 24;43(9):114660.
- Chen L*, Chen GJ, Zhang MT, Zhang XJ*. Modeling sporadic juvenile ALS in iPSC-derived motor neurons explores the pathogenesis of FUSR503fs mutation. Frontiers in cellular neuroscience, 2024, 18:1364164.
- Liu ZH, Li J, Bian Y, Zhang XJ*, Cai XJ*, Zheng YY*. Low-intensity pulsed ultrasound reduced lymphedema by regulating macrophage polarization and enhancing microcirculation. Frontiers in Bioengineering and Biotechnology. 2023, 5(11): 1173169.
- Shen XY, Zhang JW, Zhan FX, Tian WT, Jiang QQ, Luan XH, Zhang XJ*, Cao L*. Heterogeneous clinical phenotypes of dHMN caused by mutation in HSPB1 gene: a case series. Biomolecules, 2022, 12:1382.
- Lu KL, Liu L, Xu XF, Zhao F, Deng JS, Tang X, Wang XZ, Zhao BQ, Zhang XJ*, Zhao YW*. ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 2020, 17(1):67.
- Zhang JW, Liu Y, Zheng YL, Luo Y, Du Y, Zhao Y, Guan J, Zhang XJ*, Fu JL*. TREM-2 - p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus. Journal of Neuroinflammation. 2020, 17(1):2.
- Zhang XJ*, Chen S*, Lu KL, Wang F, Deng JS, Xu ZW, Wang XZ, Zhou QM, Le WD, Zhao YW. Verapamil ameliorates motor neuron degeneration and improves lifespan in the SOD1G93A mouse model of ALS by enhancing autophagic flux. Aging and Disease, 2019. 10(6): 1159-1173.
- 01/01/2023-12/31/2025
Interdisciplinary Program of Shanghai Jiao Tong University, ¥300,000, YG2023QNB18
The role of low-intensity ultrasound in a mouse model of Amyotrophic lateral sclerosis
Role: Principal Investigator - 12/01/2023-11/30/2026
Key Project of Shanghai Municipal Commission of Science and Technology, ¥300,000, 23Y11900800
A clinical trial of low-intensity ultrasound in Amyotrophic lateral sclerosis
Role: Project leader
- [Xiaojie Zhang, Yuanyi Zheng, Zihao Liu, Yuwu Zhao] (2023), “Ultrasound to treat amyotrophic lateral sclerosis in the animal model ”, ZL 202211550779.5
