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ZHONG Biao
- Chief Physician, Graduate Supervisor
- Department: Orthopedics
- Research Area: Surgery (Orthopedics)
- Research Interests: Pathogenesis of traumatic heterotopic ossification
- Contact: biao.zhong@sjtu.edu.cn
- Chief Physician, Shanghai Sixth People's Hospital, Orthopaedic Surgery, 2020.01-Present
- Associate Chief Physician, Shanghai Sixth People's Hospital, Orthopaedic Surgery, 2015.11-2019.12
- Visiting Scholar, Harborview Medical Center, Orthopaedic Surgery, 2015.10-2015.11
- Associate Chief Physician, Shanghai Sixth People's Hospital, Orthopaedic Surgery, 2006.01-2015.09
- Attending Doctor, Shanghai Sixth People's Hospital, Orthopaedic Surgery, 2003.10-2005.12
- Visiting Scholar, Graz Trauma Hospital, Orthopaedic Surgery, 2003.07-2003.09
- Attending physician, Shanghai Sixth People's Hospital, Orthopaedic Surgery, 1998.12-2003.06
- Resident, Shanghai Sixth People's Hospital, Orthopaedic Surgery, 1995.07-1998.11
- M.D. from Shanghai Jiao Tong University School of Medicine, 2014.09-2017.12
- M.M. from Shanghai Second Medical University, 1993.09-1995.07
- B.D. from Shanghai Second Medical University, 1988.09-1993.07
- Member, Orthopaedic Trauma Committee, Orthopaedic Surgeons Branch, Chinese Medical Doctor Association
- Member, Orthopaedic Trauma Group, Orthopaedic Branch, China International Exchange and Promotive Association for Medical and Health Care
- Member, Orthopaedic Committee, Shanghai Association of Social Medical Institutions
- Member, Committee of Popular Science Specialty Branch, Shanghai Medical Association
- International Faculty of AO Trauma
- Guo S, Wu Y, Chia W, Hsu P, Wang H, Wang Y, Zhong B#. Hypermethylation of the ALOX12 and CBS promoters in osteoporosis: Potential biomarkers for early diagnosis. Genes Dis. 2023 Apr 10;11(1):30-33. doi: 10.1016/j.gendis.2023.03.005.
- Zheng Y, Yan J, Zhang X, Cui H, Wei Z, Li X, Wang Q, Zhong B#. Dietary intervention reprograms bone marrow cellular signaling in obese mice. Front Endocrinol (Lausanne). 2023 Jul 10;14:1171781. doi: 10.3389/fendo.2023.1171781.
- Zhang C, Zhang W, Zhu D, Li Z, Wang Z, Li J, Mei X, Xu W, Cheng K, Zhong B#. Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy. J Nanobiotechnology. 2022 Jan 15;20(1):35.
- Wei Z, Guo S, Wang H, Zhao Y, Yan J, Zhang C, Zhong B#. Comparative proteomic analysis identifies differentially expressed proteins and reveals potential mechanisms of traumatic heterotopic ossification progression. J Orthop Translat. 2022 May 14;34:42-59.
- Zhang W, Liu J, Zhang C, Yu X, Zhong B#. Structural definition of the discrete hotspot sites of BMP-2 conformational wrist epitope and rational design of the hotspot-derived osteogenic peptides against chondrocyte senescence. Bioorg Chem. 2021 Nov;116:105382.
- Wei Z, Zhao Y, Hsu P, Guo S, Zhang C, Zhong B#. Exosomes for gene therapy effectively inhibit the endothelial-mesenchymal transition in mouse aortic endothelial cells. BMC Musculoskelet Disord. 2021 Nov 30;22(1):1000.
- Guo S, Chia W, Wang H, Bushinsky DA, Zhong B#, Favus MJ. Vitamin D receptor (VDR) contributes to the development of hypercalciuria by sensitizing VDR target genes to vitamin D in a genetic hypercalciuric stone-forming (GHS) rat model. Genes Dis. 2020 Sep 30;9(3):797-806. doi: 10.1016/j.gendis.2020.09.001.
- Zhang C, Hsu P, Wang D, Zhang W, Zhang C, Guo S, Yang W, Wei X, Zhang Y, Zhong B#. Superparamagnetic iron oxide (SPIO) nanoparticles labeled endothelial progenitor cells (EPCs) administration inhibited heterotopic ossification in rats. Nanomedicine. 2019 Oct;21:102078.
- Zhang C, Zhang Y, Zhong B#, Luo CF. SMAD7 prevents heterotopic ossification in a rat Achilles tendon injury model via regulation of endothelial-mesenchymal transition. FEBS J. 2016 Apr;283(7):1275-85.
- Zhang C, Zhong B#, Luo CF. Treatment strategy of terrible triad of the elbow: experience in Shanghai 6th People's Hospital. Injury. 2014 Jun;45(6):942-8.
- 01/01/2018-12/31/2021
National Natural Science Foundation of China (General Program), ¥550,000, 81772426
Functionalized exosome-based targeted delivery strategy in gene therapy for heterotopic ossification
Role: Project leader - 01/01/2017-12/31/2019
National Natural Science Foundation of China (Young Scientists Fund), ¥170,000, 81601956
CD34 antibody-modified Smad7-chitosan nanoparticles to inhibit heterotopic ossification disorder by modulating the endothelial cell mesenchymalization pathway
Role: Principal Investigator - 06/01/2015-12/31/2015
Science and Technology Commission of Shanghai Municipality, ¥50,000, 15dz2353800
Community-based prevention of hip fractures in the elderly
Role: Project leader - 01/01/2014-12/31/2016
Shanghai Municipal Public Health Bureau (Youth Research Program), ¥20,000, 0134y110
CD34 antibody Fab fragment-modified Smad-7pDNA/chitosan nanoparticles slow-release modulation of endothelial cell mesenchymalization pathway to inhibit heterotopic ossification disorder
Role: Principal Investigator - 01/01/2014-12/31/2017
National Natural Science Foundation of China (General Program), ¥590,000, 81371961
Biomechanical study and finite element analysis of injury mechanism and posterior fixation of posterior tibial plateau fracture
Role: Principal Investigator - 09/01/2013-09/01/2016
Science and Technology Commission of Shanghai Municipality (Research Program Projects), ¥1,050,000, 13DZ1940703
A multicenter clinical controlled study to evaluate the safety and efficacy of a metal locking bone plate system for the treatment of extremity fractures
Role: Principal Investigator - 01/01/2011-12/31/2013
National Natural Science Foundation of China (Young Scientists Fund), ¥200,000, 81000794
ERK2 as a target to inhibit joint capsular contracture
Role: Principal Investigator - 01/01/2008-07/31/2011
Shanghai Sixth People's Hospital, ¥8,000, 0778
A comprehensive study of the anatomy of the coronoid process of the ulna and the stability of the elbow joint and its clinical significance
Role: Project leader
- [Zhenyuan Wei, Biao Zhong] (2022), “A gene-carrying exosome and its preparation method, application”, CN202210146391.2[P].
