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ZHENG Xiaojiao  

  • Doctoral Supervisor, Researcher
  • Department: Translational Medicine Center
  • Research Area: Internal Medicine (Endocrinology and Metabolism)
  • Research Interests: Gut microbiome and metabolism in the pathogenesis of metabolic diseases
  • Contact: joyzheng99@sjtu.edu.cn
Biography Publications
  • Excellent Young Scholar of the National Natural Science Foundation of China (NSFC), 2021
  • Shanghai Natural Science Award, Second Prize, 2016
  • Researcher, Center for Translational Medicine, Shanghai Sixth People's Hospital, 2013-present
  • Visiting Scholar of University of North Carolina at Greensboro, 2010-2012
  • PhD from Shanghai Jiao Tong University School of Pharmacy, 2013
  • BS from Shanghai Jiao Tong University School of Pharmacy, 2007
  1. Junliang Kuang, Jieyi Wang, Yitao Li, Mengci Li, Mingliang Zhao, Kun Ge, Dan Zheng, Kenneth C.P. Cheung, Boya Liao, Shouli Wang, Tianlu Chen, Yinan Zhang, Congrong Wang, Guang Ji, Peng Chen, Hongwei Zhou, Cen Xie, Aihua Zhao, Weiping Jia*, Xiaojiao Zheng*, Wei Jia*. Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis. Cell Metabolism. 2023. 35(10):1752-1766.e8.
  2. Wei Jia*, Yitao Li, Kenneth C P Cheung, Xiaojiao Zheng*. Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis. Science China Life Sciences. 2023. DOI:10.1007/s11427-023-2353-0. 
  3. Mengci Li, Shouli Wang, Yitao Li, Mingliang Zhao, Junliang Kuang, Dandan Liang, Jieyi Wang, Cynthia Rajani, Xinran Ma, Yajun Tang, Zhenxing Ren, Tianlu Chen, Aihua Zhao, Cheng Hu, Chengxing Shen, Ping Liu, Xiaojiao Zheng*, Wei Jia*. Gut microbiota - bile acid crosstalk contributes to the rebound weight gain in individuals after calorie restriction. Nature Communications. 2022. 13(1):2060.
  4. Jieyi Wang#, Dan Zheng#, Fengjie Huang#, Aihua Zhao, Junliang Kuang, Zhenxing Ren, Tianlu Chen, Jing Lei, Jingchao Lin, Xiaoning Wang, Wei Jia, Guoxiang Xie*, Xiaojiao Zheng*. Theabrownin and poria cocos polysaccharide improve lipid metabolism via modulation of bile acid and fatty acid metabolism. Frontiers In Pharmacology. 2022. 13:875549. 
  5. Weijun Huang#, Anyuan Zhong#, Huajun Xu*, Chong Xu, Anzhao Wang, Fan Wang, Xinyi Li, Yupu Liu, Jianyin Zou, Huaming Zhu, Xiaojiao Zheng*, Hongliang Yi*, Jian Guan, Shankai Yin. Metabolomics analysis on obesity-related obstructive sleep apnea after weight loss management: a preliminary study. Frontiers In Endocrinology. 2022. 12:761547.  
  6. Wu Lirong, Zhao Mingliang, Li Mengci, Guo Qihao, Ren Zhenxing, Zheng Xiaojiao*, Chen Tianlu*. The clinical and mechanistic roles of bile acids in depression, Alzheimer's disease, and stroke. Proteomics. 2022. 22(15-16):e2100324. 
  7. Xiaojiao Zheng#, Tianlu Chen#, Runqiu Jiang#, Aihua Zhao#, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia*, Changtao Jiang*, Wei Jia*. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metabolism. 2021. 33(4):791-806.
  8. Xiaojiao Zheng#, Tianlu Chen#, Aihua Zhao#, Zhangchi Ning#, Junliang Kuang, Shouli Wang, Yijun You, Yuqian Bao, Xiaojing Ma, Haoyong Yu, Miao Jiang, Mengci Li, Xiaolong Han, Meilin Wei, Yitao Li, Kun Ge, Cynthia Rajani, Guoxiang Xie, Cheng Hu, Aiping Lu*, Weiping Jia*, Wei Jia*. Hyocholic acid species as novel biomarkers for metabolic disorders. Nature Communications. 2021. 12(1):1487.
  9. Wei Jia*, Meilin Wei, Cynthia Rajani, Xiaojiao Zheng*. Targeting The alternative bile acid synthetic pathway for metabolic diseases. Protein & Cell. 2021. 12(5):411-425. 
  10. Wei Jia*, Cynthia Rajani, Hongxi Xu, Xiaojiao Zheng*. Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma. Protein & Cell. 2021. 12(5):374-393.
  11. Xiaojiao Zheng#*, Kejun Zhou#, Yunjing Zhang, Xiaolong Han, Aihua Zhao, Jiajian Liu, Chun Qu, Kun Ge, Fengjie Huang, Brenda Hernandez, Herbert Yu, Jun Panee, Tianlu Chen, Weiping Jia, Wei Jia*. Food withdrawal alters the gut microbiota and metabolome in mice. FASEB Journal. 2018. 32(9):4878-4888. 
  12. Xiaojiao Zheng, Shouli Wang, Wei Jia*. Calorie restriction and its impact on gut microbial composition and global metabolism. Frontiers of Medicine. 2018. 12(6):634-644. 
  13. Xiaojiao Zheng, Fengjie Huang, Aihua Zhao, Sha Lei, Yunjing Zhang, Guoxiang Xie, Tianlu Chen, Chun Qu, Cynthia Rajani, Bing Dong, Defa Li, Wei Jia*. Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice. BMC Biology. 2017. 15(1):120. 
  14. Xiaojiao Zheng#, Aihua Zhao#*, Guoxiang Xie, Yi Chi, Linjing Zhao, Houkai Li, Congrong Wang, Yuqian Bao, Weiping Jia, Micheal Luther, Mingming Su, Jeremy K Nicholson, Wei Jia*. Melamine-induced renal toxicity is mediated by the gut microbiota. Science Translational Medicine. 2013. 5(172): 172ra22.
  15. Xiaojiao Zheng, Yunping Qiu, Wei Zhong, Shara Baxter, Mingming Su, Qiong Li, Guoxiang Xie, Brandon M Ore, Shanlei Qiao, Melanie D Spencer, Steven H Zeisel, Zhanxiang Zhou, Aihua Zhao*, Wei Jia*. A targeted metabolomic protocol for short-chain fatty acids and branched-chain amino acids. Metabolomics. 2013. 9(4): 818-827. 
  16. Xiaojiao Zheng, Guoxiang Xie, Wei Jia*. Metabolomic profiling in colorectal cancer: opportunities for personalized medicine. Personalized Medicine. 2013. 10(7): 741-755. 
  17. Xiaojiao Zheng, Guoxiang Xie, Aihua Zhao, Linjing Zhao, Chun Yao, Norman HL Chiu, Zhanxiang Zhou, Yuqian Bao, Weiping Jia, Jeremy K Nicholson, Wei Jia*. The footprints of gut microbial-mammalian co-metabolism. Journal Of Proteome Research. 2011. 10(12): 5512-5522.

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