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ZHENG Xianyou  

  • Doctoral Supervisor, Professor
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Spinal cord injury repair, reconstruction and bone repair materials
  • Contact: zhengxianyou@126.com
Biography Positions Publications Patents
  • Deputy Director of Department of Orthopedics, Shanghai Sixth People's Hospital, 2022
  • Chief Physician at Department of Orthopedics, Shanghai Sixth People's Hospital, 2016
  • Chief Resident at Department of Orthopedics, Shanghai Sixth People's Hospital, 2009  
  • Post-doc at Shanghai Changzheng Hospital, 2008
  • PhD from Fudan University, 2005
  • MMed from Weifang Medical University, 2002
  • MD from Weifang Medical University, 1999
  • Vice President of Shanghai Sixth People's Hospital
  • Vice Chairman of the 8th Committee of the Microsurgery Branch of Shanghai Medical Association
  • Member of the Standing Committee of the 11th Committee of the Microsurgery Branch of the Chinese Medical Association
  1. Zhu H, Zhu X, Zheng X. Antithrombotic therapies in digit replantation with papaverine administration: A prospective, observational study. Plast Reconstr Surg. 2017,140(4):743-746.   
  2. Zhu H, Zhu X, Zhang C, Zheng X. Risk Factors of Acute Hand Injuries in Manual Workers: A Case-control study. Scientific Reports, 2017 Sep 22;7(1):12208. 
  3. Zhu H, Bao B, Zheng X. Three-screw versus two-screw fixation of distal fragment in fifth metacarpal neck fractures stabilized with locking plate. Sci Rep, 2017, Oct 2;7(1):12516.  
  4. Zhu H, Xu Z, Wei H, Zheng X. Locking Plate Alone versus in Combination with Two Crossed Kirschner Wires for Fifth Metacarpal Neck Fracture. Sci Rep. 2017 Apr 5; 7:46109.  
  5. Zhu H, Li X, Zheng X. A Descriptive Study of Open Fractures Contaminated by Seawater: Infection, Pathogens, and Antibiotic Resistance. Biomed Res Int.2017:2796054. 
  6. Song J, Li X, Li Y, Zheng X, et al. Biodegradable and biocompatible cationic polymer delivering microRNA-221/222 promotes nerve regeneration after sciatic nerve crush. International Journal of Nanomedicine, 2017, 12:4195-4208. 
  7. Zhu X, Zhu H, Zhang C, Zheng X. Pre-operative predictive factors for the survival of replanted digits. Int Orthop. 2017 Aug,41(8):1623-1626. 
  8. Ding Z, Zhu X, Fu K, Zheng X. Digital Lengthening to Treat Finger Deficiency: An Experience of 201 Digits in 104 Patients. Biomed Res Int. 2017; 4934280. 
  9. Zhu H, Zhu X, Zhang C, Zheng X. Patency Test of Vascular Anastomosis with Assistance of High-Speed Video Recording in Digit Replantation. J Bone Joint Surg Am, 2018,100(9):729-734. 
  10. Zhu H, Gao Y, Zhang C, Zheng X. A Prospective Evaluation of Patient-Reported Opioid Utilization After Nonoperative Treatment of Fractures and Dislocations. J Bone Joint Surg Am. 2018 Jul 18;100(14):1177-1183. 
  11. Zhu H, Bao B, Zheng X. Is NS-EDTA Effective in Clearing Bacteria From Infected Wounds in a Rat Model? Clin Orthop Relat Res. 2018 May;476(5):1083-1090. 
  12. Zhu H, Bao B, Zheng X. A Comparison of Functional Outcomes and Therapeutic Costs: Single Digit Replantation versus Revision Amputation. Plast Reconstr Surg. 2018 Feb;141(2):244e-249e. 
  13. Bao B, Zhu H, Zheng X. Plate versus Kirschner wire fixation in treatment of fourth and fifth carpometacarpal fracture-dislocations: A retrospective cohort study. Int J Surg. 2018 Apr;52:293-296. 
  14. Bao B, Zhu H, Zheng X. Reply: Antithrombotic Therapies in Digit Replantation with Papaverine Administration: A Prospective, Observational Study.Plast Reconstr Surg. 2018 Sep;142(3):419e-420e. 
  15. Bao BB, Qu DQ, Zhu HY, Gao T, Zheng XY. Brain remodeling after chronic median nerve compression in a rat model. Neural Regen Res, 2018;13(4):704-708. 
  16. Tao Gao, Hongyi Zhu, Changqing Zhang, Xianyou Zheng. Efficacy of acetaminophen with and without oxycodone for analgesia in non-operative treatment of extremity fractures in adults: Protocol for a double-blind randomized clinical trial. [J]. Trials. (2019)20:510. 
  17. Li X, Zhu H, Zhang C, Chai Y, Zheng X. Replantation of a Completely Amputated Thumb with Assistance of High-Speed Video Recording. J Bone Joint Surg Am-EST. 2019, 9(2):e12(1-4).
  18. Qian Y, Cheng Y, Song J, Xu Y, Yuan WE, Fan C, Zheng X. Mechano-Informed Biomimetic Polymer Scaffolds by Incorporating Self-Powered Zinc Oxide Nanogenerators Enhance Motor Recovery and Neural Function. Small. 2020 Aug;16(32):e2000796.
  19. Gao T, Lin J, Zhang C, Zhu H, Zheng X. Is intracellular Staphylococcus aureus associated with recurrent infection in a rat model of open fracture? Bone Joint Res. 2020 May 16;9(2):71-76. 
  20. Zhu H, Lin J, Wei H, Bao B, Gao T, Zheng X. Does Training Innate Immunity Confer Broad-spectrum Protection Against Bone and Joint Infection in a Mouse Model? Clin Orthop Relat Res. 2020 Nov;478(11):2670-2681. 
  21. Zhu H, Bao B, Wei H, Gao T, Chai Y, Zhang C, Zheng X. Is EDTA Irrigation Effective in Reducing Bacterial Infection in a Rat Model of Contaminated Intra-articular Knee Implants? Clin Orthop Relat Res. 2020 May;478(5):1111-1121. 
  22. Bao B, Fu K, Zheng X, Wei H, Luo P, Zhu H, Zhu X, Li X, Gao T. Novel method for restoration of anorectal function following spinal cord injury via nerve transfer in rats. J Spinal Cord Med. 2020 Mar;43(2):177-184.
  23. Shen J, Wang J, Liu X, Sun Y, Yin A, Chai Y, Zhang K, Wang C, Zheng X. In Situ Prevascularization Strategy with Three-Dimensional Porous Conduits for Neural Tissue Engineering. ACS Appl Mater Interfaces. 2021 Nov 3;13(43):50785-50801.
  24. Shen J, Sun Y, Liu X, Zhu Y, Bao B, Gao T, Chai Y, Xu J, Zheng X. EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/β-catenin signaling. Stem Cell Res Ther. 2021 Jul 22;12(1):415. 
  25. Lin J, Gao T, Wei H, Zhu H, Zheng X. Optimal concentration of ethylenediaminetetraacetic acid as an irrigation solution additive to reduce infection rates in rat models of contaminated wound. Bone Joint Res. 2021 Jan;10(1):68-76. 
  26. Zhu H, Wang J, Gao T, Tian M, Xia L, Cai Q, Zhang C, Xu Y, Zheng X. Contribution of revision amputation vs replantation for certain digits to functional outcomes after traumatic digit amputations: A comparative study based on multicenter prospective cohort. Int J Surg. 2021 Nov 10;96:106164. 
  27. Lin J, Huang T, Wei H, Bao B, Gao T, Zheng X, Zhu H. Does Preoperative Glycemic Control Restore Immune Defense Against Implant-related Infection in Mice with Diabetes? Clin Orthop Relat Res. 2021 Nov 19. 
  28. Bao B, Wei H, Luo P, Zhu H, Hu W, Sun Y, Shen J, Zhu T, Lin J, Huang T, Li J, Wang Z, Li Y, Zheng X. Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study. Front Neurosci. 2021 Jul 20;15:704079. 
  29. Bao B, Duan L, Wei H, Luo P, Zhu H, Gao T, Wei X, Li J, Li Y, Chai Y, Zhang C, Zheng X. Changes in Temporal and Spatial Patterns of Intrinsic Brain Activity and Functional Connectivity in Upper-Limb Amputees: An fMRI Study. Neural Plast. 2021 Apr 23;2021:8831379. 
  30. Zhu XZ, Huang TL, Zhu HY, Bao BB, Gao T, Li XW, Lin JQ, Zheng XY. A retrospective cohort study on prevalence of postoperative complications in comminuted patellar fractures: comparisons among stabilized with Cannulated-Screw, Kirschner-Wire, or Ring-Pin Tension Bands. BMC Musculoskelet Disord. 2021 Jan 11;22(1):60.
  31. Sun Y, Liu X, Zhu Y, Han Y, Shen J, Bao B, Gao T, Lin J, Huang T, Xu J, Chai Y, Zheng X. Tunable and Controlled Release of Cobalt Ions from Metal-Organic Framework Hydrogel Nanocomposites Enhances Bone Regeneration. ACS Appl Mater Interfaces. 2021 Dec 15;13(49):59051-59066. 
  32. Suo J, Zou S, Wang J, Han Y, Zhang L, Lv C, Jiang B, Ren Q, Chen L, Yang L, Ji P, Zheng X, Hu P, Zou W. The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Res. 2022 Mar 17;10(1):31. 
  33. Bao B, Gao T, Li X, Wei H, Lin J, Sun Y, Shen J, Zhu H, Zheng X. Breaking the technical barrier of microvascular anastomosis with high-speed videography: A prospective cohort study. Int J Surg. 2022 Feb;98:106214. 
  34. Bao B, Wei H, Zhu H, Zheng X. Transfer of Soleus Muscular Branch of Tibial Nerve to Deep Fibular Nerve to Repair Foot Drop After Common Peroneal Nerve Injury: A Retrospective Study. Front Neurol. 2022 Feb 11;13:745746. 
  35. Gao T, Lin J, Wei H, Bao B, Zhu H, Zheng X. Platelets mediate trained immunity against bone and joint infections in a mouse model. Bone Joint Res. 2022 Feb;11(2):73-81. 
  36. Huang T, Shen J, Bao B, Hu W, Sun Y, Zhu T, Lin J, Gao T, Li X, Zheng X. Mitochondrial-targeting antioxidant MitoQ modulates angiogenesis and promotes functional recovery after spinal cord injury. Brain Res. 2022 Jul 1;1786:147902. 
  37. Lin, Junqing, Zheng X et al. "ε-Poly-l-lysine as an efficient cartilage penetrating and residing drug carrier with high intraarticular injection safety for treating osteoarthritis." Chemical Engineering Journal 430 (2022): 133018. 
  38. Sun Y, Bao B, Zhu Y, Zheng X. et al. An FPS-ZM1-encapsulated zeolitic imidazolate framework as a dual proangiogenic drug delivery system for diabetic wound healing. Nano Res. (2022).
  39. Bao, Bing-Bo; Zhu, Hong-Yi; Wei, Hai-Feng; Li, Jing; Wang, Zhi-Bin; Li, Yue-Hua; Hua, Xu-Yun; Zheng, Mou-Xiong; Zheng, Xian-You. Altered intra- and inter-network brain functional connectivity in upper-limb amputees revealed through independent component analysis. Neural Regeneration Research. 2022, 17(12):2725-2729. 
  1. [Xianyou Zheng, Hongyi Zhu, Bingbo Bao] (2022), “A steel plate internal fixation device suitable for metacarpal head and neck fractures”, CN202023012278   
  2. [Xianyou Zheng, Hongyi Zhu, Tao Gao] (2021), “A microscope suitable for microsurgery”, CN214375543U                                                                                                                                                                                           

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