Research
Search
Close
ZHANG Zhenlin
- Doctoral Supervisor, Professor
- Department: Osteoporosis and Bone Diseases
- Research Area: Internal Medicine (Endocrinology and Metabolism)
- Research Interests: Pathogenesis of osteoporosis and metabolic bone diseases
- Contact: zhangzl@sjtu.edu.cn
- Postdoctoral Fellow, Fudan University, 2002
- MD from Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Endocrinology & Metabolism，2000
- Medical Master Degree from Kunming Medical College, Pediatrics, 1997
- Director, Department of Osteoporosis and Bone Diseases, Shanghai Sixth People’s Hospital
- Executive Director, Clinical Research Center of Shanghai Sixth People’s Hospital
- Chairman, Chinese Society of Bone Mineral Research
- Zhang ZL*, Xia WB, He JW, Zhang Z, Ke YH, Yue H, Wang C, Zhang H, Gu JM, Hu WW, Fu WZ, Hu YQ, Li M, Liu YJ. Exome sequencing identifies SLCO2A1 mutations as a cause of primary hypertrophic osteoarthropathy Am J Hum Genet 2012 Jan 13;90(1):125-32
- Li SS, He JW, Fu WZ1, Liu YJ, Hu YQ, Zhang ZL. Clinical, Biochemical, and Genetic Features of 41 Han Chinese Families With Primary Hypertrophic Osteoarthropathy, and Their Therapeutic Response to Etoricoxib: Results From a Six-Month Prospective Clinical Intervention. J Bone Miner Res. 2017;32(8):1659-1666.
- Xu Y, Zhang Z, Yue H, Li S, Zhang Z. Monoallelic mutations in SLCO2A1 cause autosomal dominant primary hypertrophic osteoarthropathy. J Bone Miner Res. 2021 Aug;36(8):1459-1468.
- Lu Q, Xu Y, Li S, Zhang Z, Sheng J, Zhang Z. Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations. Int J Biol Sci. 2022 Jun 6;18(9):3908-3917
- Zhang Z, He JW, Fu WZ, Zhang CQ, Zhang ZL*.Mutations in the SLCO2A1 gene and primary hypertrophic osteoarthropathy: a clinical and biochemical characterization J Clin Endocrinol Metab. 2013;98(5):E923-33
- Chen L, Shan C, Xu S, Deng X, Guo B, Jiao Q, Zhang L, Fan Y, Yue H, Zhang Z. Single-Cell Transcriptomic Atlas of Parathyroid Adenoma and Parathyroid Carcinoma. J Bone Miner Res. 2023 Jul;38(7):994-1005.
- Shen L, Gao C, Hu S, Kang D, Zhang Z, Xia DD, Xu YR, Xiang SK, Zhu Q, Xu GW, Tang F, Yue H, Yu W, Zhang ZL. Using Artificial Intelligence to Diagnose Osteoporotic Vertebral Fractures on Plain Radiographs. J Bone Miner Res. 2023 Sep;38(9):1278-1287.
- Wei Z, Li S, Tao X, Zhu G, Sun Z, Wei Z, Jiao Q, Zhang H, Chen L, Li B, Zhang Z, Yue H. Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors. J Bone Miner Res. 2021 Jun;36(6):1088-1103.
- Zhang Z, He JW, Fu WZ, Zhang CQ, Zhang ZL*.An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population J Bone Miner Res.2013;28(8):1784-92.
- Wang C, Zhang Z, Zhang H, He JW, Gu JM, Hu WW, Hu YQ, Li M, Liu YJ, Fu WZ, Yue H, Ke YH, Zhang ZL*. Susceptibility genes for osteoporotic fracture in postmenopausal Chinese women J Bone Miner Res 2012;27(12):2582-91.
- 01/01/2018-12/31/2021
National Natural Science Foundation of China，￥520,000，81770871
Identification of Risk Genotypes and Functional Study of Adefovir Dipivoxil-induced Hypophosphatemic Osteomalacia through Deep Sequencing of Drug Transporter Genes
Role: Principal Investigator - 1/01/2018-11/30/2021
Shanghai Shenkang Hospital Development Center Clinical Science and Technology Innovation Project，￥800,000，SHDC12018120
Establishment of Clinical Diagnosis and Intervention System for Developmental Disorders
Role: Principal Investigator - 09/01/2019-08/31/2024
Sub project of the Key R&D Program of the Ministry of Science and Technology of the People's Republic of China，￥5,020,000，2018YFA0800801
Establishment of Genetic Resource Bank for Disorders of Calcium and Phosphorus Metabolism and Construction of New Pathogenic Gene Cloning and Mutation Gene Spectrum
Role: Project leader - 01/01/2020-12/31/2024
National Natural Science Foundation of China，￥550,000，81974123
Molecular Genetic Mechanisms of Pathogenesis of Hypophosphatemic Osteomalacia Caused by Phosphaturicmesenchymal Tumor
Role: Principal Investigator - 07/01/2022-09/30/2024
Three year Action Plan for Shanghai Shenkang Hospital Development Center，￥3,000,000，SHDC2022CRT022
Establishment and Clinical Application of an Auxiliary Intelligent Diagnosis System for Osteoporotic Vertebral Fractures
Role: Principal Investigator
