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ZHANG Zhengyun
- Graduate Supervisor, Associate Chief Physician
- Department: General Surgery
- Research Area: Surgery (General Surgery)
- Research Interests: Colorectal cancer and its liver metastasis
- Contact: zhengyunzhshjtu@126.com
- PhD from Sungkyunkwan University, Korea, 2013;
- MS from Shanghai Jiao Tong University, China, 2008;
- MD from Fudan University, China, 2005
- Associate Chief Physician, Department of General Surgery, Shanghai Sixth People's Hospital
- Associate Researcher, Shanghai Jiao Tong University School of Medicine
- Expert Member, Youth Physician Expert Working Group of the Surgery Physician Branch of the Chinese Medical Association
- Committee Member, Biliary Tract Group of the Accelerated Recovery Surgery Specialty Committee of the China Research Hospital Association
- Committee Member, Youth Committee of the Endoscopic Sub-Committee of Gastrointestinal Tumors of the Shanghai Anti-Cancer Association
- Youth Committee Member, Biliary Surgery Physician Committee of the Surgery Physician Branch of the Chinese Medical Association
- Yao J, Wang XP, Yang J, Yang Z, Zhang ZY#. SCF-FBXL8 contributes to liver metastasis and stem-cell-like features in colorectal cancer cells by mediating ubiquitination and degradation of TP53. Clin Transl Med, 2023, doi: 10.1002/ctm2.1208
- Zhou ZQ, Zhang Y, Xu ZY, Tang XL, Chen XH, Guan J, Zhang ZY#. Dissecting cellular heterogeneity and intercellular communication in cholangiocarcinoma: implications for individualized therapeutic strategies. Front Genet. 2024, doi: 10.3389/fgene.2023.1241834
- Zhang ZY, Sun JH, Liang MJ, Wang XP, Guan J, Zhou ZQ#. The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer. Int J Biochem Cell Biol, 2023, doi: 10.1016/j.biocel.2023.106408
- Zhang ZY, Guan J, Wang XP, Hao DS, Zhou ZQ#. Outcomes of adolescent and young patients with hepatocellular carcinoma after curative liver resection: a retrospective study. World J Surg Oncol. 2022, doi: 10.1186/s12957-022-02658-3
- Yao J, Yang J, Yang Z, Wang XP, Yang T, Ji B, Zhang ZY#. FBXW11 contributes to stem-cell-like features and liver metastasis through regulating HIC1-mediated SIRT1 transcription in colorectal cancer. Cell Death Dis, 2021, doi: 10.1038/s41419-021-04185-7
- Yao J, Yang Z, Yang J, Wang ZG, Zhang ZY#. Long non-coding RNA FEZF1-AS1 promotes the proliferation and metastasis of hepatocellular carcinoma via targeting miR-107/Wnt/β-catenin axis. Aging (Albany NY). 2021, doi: 10.18632/aging.202960.
- Guan J, Zhou ZQ, Chen MH, Li HY, Tong DN, Yang J, Yao J, Zhang ZY#. Folate-conjugated and pH-responsive polymeric micelles for target-cell-specific anticancer drug delivery. Acta Biomater. 2017, doi: 10.1016/j.actbio.2017.07.018
- Li H, Zhou ZQ, Yang ZR, Tong DN, Guan J, Shi BJ, Nie J, Ding XT, Li B, Zhou GW, Zhang ZY#. MicroRNA-191 acts as a tumor promoter by modulating the TET1-p53 pathway in intrahepatic cholangiocarcinoma. Hepatology. 2017, doi: 10.1002/hep.29116
- Zhou ZQ, Tong DN, Guan J, Li MF, Feng QM, Zhou MJ, Zhang ZY#. Circulating follicular helper T cells presented distinctively different responses toward bacterial antigens in primary biliary cholangitis. Int Immunopharmacol. 2017, doi: 10.1016/j.intimp
- Zhang ZY, Hong D, Nam SH, Kim JM, Paik YH, Joh JW, Kwon CH, Park JB, Choi GS, Jang KY, Park CK, Kim SJ#. SIRT1 regulates oncogenesis via a mutant p53-dependent pathway in hepatocellular carcinoma. J Hepatol. 2015, doi: 10.1016/j.jhep.2014.08.007
