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ZHANG Yonglong
- Doctoral Supervisor, Associate Professor
- Department: Laboratory Medicine
- Research Area: Oncology
- Research Interests: Cancer Metabolism and Immunity
- Contact: yonglz@sjtu.edu.cn
- PhD from Fudan University, 2016
- MPH from Southwest University, 2009
- Professor, Department of Clinical Laboratory, Shanghai Sixth People's Hospital
- Member of the Society of Tumor Microenvironment, Chinese Anti-Cancer Association; STMC
- Sun Y, Zhang Y, Duan J, Qiao K, Yan Guoquan Xue J, Wang J, Zhan M, Li Q, Wang H, Zhang Y. Cyclin K Condensates Bridge CDK12 to Phosphorylate and Drive Oncogenic YAP Activation in Hepatocellular Carcinoma. Science Advances, 2025 (Accepted)
- Sun Y, Chen Y, Duan J, Xue J, Huang W, Di J, Zhang Y. Therapeutic Targeting of the PRMT6/FOXK1 Axis Restores Lipid Homeostasis and Ameliorates Hepatic Steatosis and Steatohepatitis in Mice, Acta Pharmaceutica Sinica B, 2025 (In press)
- Duan J, Chen T, Li Q, Zhang Y, Lu T, Xue J, Sun Y, Gao L, Zhang Y. Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer. Journal for ImmunoTherapy of Cancer. 2025 Mar 13;13(3):e010639. doi: 10.1136/jitc-2024-010639.
- Liu Y, Wang F, Yan G, Tong Y, Guo W, Li S, Qian Y, Li Q, Shu Y, Zhang L, Zhang Y*, Xia Q*. CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer. Cancer Letters. 2024 Jul 28;595:217006. doi: 10.1016/j.canlet.2024.217006.
- Yu Tong, Fan Wang, Songling Li, Wenyun Guo, Yifei Qian, Linfeng Li, Huifang Zhao, Helen Zhu, Zhang Y.*, Wei-Qiang Gao* and Yanfeng Liu*. Histone methyltransferase KMT5C drives tumor progression and dictates PARP inhibitor therapeutic response. Hepatology. 2024 Jul 1;80(1):38-54. doi: 10.1097/HEP.0000000000000559.
- Chen, T, Duan, J., Wang, F., Yuan, Z., Xue, J., Lu,T., Huang,T., Liu, Y*., Zhang, Y*. Hippocalcin-Like 1 Blunts Liver Lipid Metabolism to Suppress Tumorigenesis Via Directly Targeting RUVBL1-mTOR Signaling. Theranostics, 2022; doi:10.7150/thno.75936;
- Chen, T, Duan, J., Wang, F., Yuan, Z., Xue, J., Lu,T., Huang,T., Liu, Y*., Zhang, Y*. (2022). GSMT3 Deficiency Regulates DNA Mismatch Repair to Promote Gastric Tumorigenesis via CAND1/NRF2-KEAP1 Signaling. Cancer Letters, 2022;538:215692.
- Wang, Y., Luo. M., Li, L., Wang, F., Liu, L., Xie, Y*., Zhang,Y*., Gao, W*., Liu, Y*. (2022). AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumorigenesis. Nature Communications. 2022 Nov 24;13(1):7215.
- He, L Yuan, L. Yu, W., Sun, Y., Jiang, D., Wang, X., Feng, X., Wang, Z., Xu, J., Yang, R., Zhang, W., Feng, H., Chen, H., Zeng,Y., Hui, L., Wu, Q., Zhang, Y.*,Zhang, L*. (2020). A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis. Cell Reports, 2020;33:108284.. (*co-corresponding author)
- Zhang, Y. #*, Wang H. #, Chen, T. #, Wang, HL., Liang XW., Zhang YC., Duan, JL., ... & Wang, J*. (2021). C24-Ceramide Drives Gallbladder Cancer Progression through Directly Targeting PIP4K2C to Facilitate mTOR Signaling Activation. Hepatology, 2021, 73(2):692-712.7.
- 01/01/2025-12/31/2028
National Natural Science Foundation of China , ¥490000, 82472802
Role: Principal Investigator - 01/12/2023-12/31/2028
National Key Research and Development Project, ¥790000, 2023YFA1800803
Role: Participant
