Search

Close
Research
Home > Research > Faculty
Research

YU Xiaowei  

  • Chief Physician, Doctoral Supervisor
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Osteonecrosis of the femoral head; Bone immunity and bone regeneration; Bone and soft tissue infection; Biomedical materials
  • Contact: yuxw@sjtu.edu.cn
Biography Positions Publications Research Projects Patents Other
  • Chief Physician, Department of Orthopedics, Shanghai Sixth People's Hospital, 2016-present
  • PhD from Shanghai Jiao Tong University, 2005-2008
  • Executive Director, Department of Orthopedics, Shanghai Sixth People's Hospital (Lingang Campus)
  1. Shan H, Lin Y, Yin F, Pan C, Hou J, Wu T, Xia W, Zuo R, Cao B, Jiang C, Zhou Z, Yu X#. Effects of astragaloside IV on glucocorticoid-induced avascular necrosis of the femoral head via regulating Akt-related pathways. Cell Prolif. 2023 Apr 26:e13485.
  2. Zhang W, Lin Y, Zong Y, Ma X, Jiang C, Shan H, Xia W, Yin L, Wang N, Zhou L, Zhou Z, Yu X#. Staphylococcus aureus Infection Initiates Hypoxia-Mediated Transforming Growth Factor-β1 Upregulation to Trigger Osteomyelitis. mSystems. 2022 Aug 30;7(4):e0038022.
  3. Wang F, Min HS, Shan H, Yin F, Jiang C, Zong Y, Ma X, Lin Y, Zhou Z, Yu X#. IL-34 aggravates steroid-induced osteonecrosis of the femoral head via promoting osteoclast differentiation. Immune Netw. 2022 Mar 31;22(3):e25.
  4. Jiang C, Lin Y, Shan H, Xia W, Pan C, Wang N, Zhou L, Gao Y, Zhou Z, Yu X#. miR-146a Protects against Staphylococcus aureus-Induced Osteomyelitis by Regulating Inflammation and Osteogenesis. ACS Infect Dis. 2022 May 13;8(5):918-927.
  5. Zong Y, Shan H, Yin F, Ma X, Jiang C, Wang N, Zhou L, Lin Y, Zhou Z, Yu X#. Ddb1-Cullin4-Associated-Factor 1 in Macrophages Restricts the Staphylococcus aureus-Induced Osteomyelitis. J Inflamm Res. 2021 Apr 28;14:1667-1676.
  6. Zhang W, Hu C, Zhang C, Luo C, Zhong B, Yu X#. MiRNA-132 regulates the development of osteoarthritis in correlation with the modulation of PTEN/PI3K/AKT signaling. BMC Geriatr. 2021 Mar 10;21(1):175.
  7. Liu Y, Shan H, Zong Y, Lin Y, Xia W, Wang N, Zhou L, Gao Y, Ma X, Jiang C, Yu X#. IKKe in osteoclast inhibits the progression of methylprednisolone-induced osteonecrosis. Int J Biol Sci. 2021 Mar 30;17(5):1353-1360.
  8. Jiang C, Zhou Z, Lin Y, Shan H, Xia W, Yin F, Wang N, Zhou L, Gao Y, Yu X#. Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages. Int Immunopharmacol. 2021 Feb 6:107345.
  9. Zhou Z, Lin Y, Pan C, Wang N, Zhou L, Shan H, Gao Y, Yu X#. IL-15 deficiency alleviates steroid-induced osteonecrosis of the femoral head by impact osteoclasts via RANKL-RANK-OPG system. Immun Ageing. 2020 Jun 12;17:19.
  10. Jiang F, Zong Y, Ma X, Jiang C,Shan H, Lin Y, Xia W, Yin F, Wang N, Zhou L, Zhou Z, Yu X#. MiR-26a attenuated bone-specific insulin resistance and bone quality in diabetic mice. Mol Ther Nucleic Acids. 2020 Mar 29;20:459-467.
  • 01/01/2024-12/31/2027
    National Natural Science Foundation of China, ¥490,000, 82372387
    Spatio-temporal communication between macrophages and osteocytes in steroid-induced avascular necrosis of the femoral head and the significance as targets
    Role: Project leader
  • 11/01/2023-10/31/2026
    Shanghai Innovative Medical Device Application Demonstration Project, ¥1,950,000, 23SHS02800
    Digital X-ray photography system application demonstration project
    Role: Project leader
  • 08/01/2022-07/01/2024
    Science and Technology Innovation Action Plan of Shanghai Municipal Science and Technology Commission, ¥150,000, 22DZ2203600
    Research and development of flat foot detection technology standard based on biplane digital X-ray imaging and artificial intelligence
    Role: Project leader
  • 01/01/2024-12/31/2026
    Medical-Engineering Cross Foundation of Shanghai Jiao Tong University, ¥1,000,000, YG2024ZD19
    Study on the role of regulatory T cell function regulation mediated by magnetic vector in the prevention and treatment of steroid-induced avascular necrosis of the femoral head
    Role: Project leader
  • 01/01/2019-12/31/2022
    National Natural Science Foundation of China, ¥570,000, 81873993
    Preparation of double controlled release bone scaffold for the treatment of infectious bone defects
    Role: Project leader
  • 11/01/2019-11/31/2022
    Shanghai Shenkang Hospital Development Center Clinical Innovation Project, ¥300,000, SHDC12019X24
    Anybody software combined with artificial intelligence assisted osteotomy scheme optimization design for medial compartment knee arthritis
    Role: Project leader
  • 12/01/2019-11/31/2022
    Pudong New Area Science and technology development fund special fund for people’s livelihood Research, ¥360,000, PKJ2019-Y02
    Optimal design of artificial intelligence based on simulation analysis software for osteotomy scheme of unicompartmental knee arthritis
    Role: Project leader
  • 01/01/2016-12/31/2019
    National Natural Science Foundation of China, ¥570,000, 81572155
    The study on the treatment efficacy of ANFH by CPC Reinforced with controlling VEGF/BMP release system
    Role: Project leader
  • 07/01/2018-06/30/2021
    Shanghai Health and Family Planning Committee Hundred Talents Program, ¥450,000, 2018BR38
    Study on the treatment of osteomyelitis with double controlled release bone scaffold
    Role: Project leader
  • 07/01/2014-06/30/2017
    Shanghai Natural Science Foundation, ¥100,000, 14ZR1431800
    Study on strengthening calcium phosphate with erythromycin loaded on coaxial nano-PCL/PVA fiber in the treatment of osteomyelitis
    Role: Project leader
  1. [Xiaowei Yu, Songwei Qiu, Baoshan Wei, Haojie Shan] (2022), “A deep tissue suture device”, CN2022/11/22; ZL 202121515889.9
  2. [Xiaowei Yu, Songwei Qiu, Baoshan Wei, Haojie Shan] (2022), “A novel rapid iliac bone extractor”, CN2022/01/11; ZL 202121861058.7
  3. [Xiaowei Yu, Haojie Shan, Songwei Qiu, Baoshan Wei] (2022), “A locking nail plate system capable of selecting fixed mode”, CN2022/01/11; ZL 202121732052.X
  4. [Xiaowei Yu, Haojie Shan, Songwei Qiu, Baoshan Wei] (2022), “An internal fixator and auxiliary device for femoral neck fracture”, CN2022/01/11; ZL 202120746094.2
  5. [Xiaowei Yu, Haojie Shan, Songwei Qiu, Baoshan Wei, Changqing Zhang] (2022), “A bone distraction apparatus for the treatment of femoral head necrosis in early and middle stages”, CN2022/01/11; ZL 202120747777.X
  6. [Xiaowei Yu, Songwei Qiu, Baoshan Wei, Haojie Shan] (2022), “A circular saw cylinder bone extractor”, CN2022/04/08; ZL 202121732048.3
  7. [Xiaowei Yu, Changqing Zhang, Tianyi Wu, Haojie Shan, Songwei Qiu] (2021), “A bone focus cleaning and flushing device”, CN2021/10/22; ZL 202023008003.X
  8. [Xiaowei Yu, Changqing Zhang, Tianyi Wu, Haojie Shan, Songwei Qiu] (2021), “An injection device for bone cavity filling”, CN2021/10/22; ZL 202023008002.5
  9. [Xiaowei Yu, Changqing Zhang, Zubin Zhou, Chenhao Pan, Haojie Shan] (2020), “An injection device for bone cavity filling”, CN2020/04/07; ZL 201920288484.2
  10. [Xiaowei Yu, Chaolai Jiang] (2018), “An intramedullary fixation system for intertrochanteric fracture of femur”, CN2018/02/23; ZL 201720053389.5
  11. [Xiaowei Yu, Weiping Ren, Emily Juanjie Ren] (2017), “Fingerstall-cannulated guide for fast and accurate guide wire positioning”, United States Patent 2017/01/24; 9,549,771 B1
  12. [Xiaowei Yu, Tingting Tang] (2010), “A dynamic hip screw and device for fracture fixation enhancement”, CN2010/09/01; ZL 200920209687.4
  13. [Xiaowei Yu, Xiaolin Hua, Tianyi Wu, Ye Huang] (2012), “A stirring syringe for adding bioactive factors or drugs”, CN2012/06/20; ZL 201120343315.8
  • Outstanding academic leaders in Shanghai (2018)
  • Title of "Lingang Talents" in Shanghai Pilot Free Trade Zone in 2021
  • Third Prize of Science and Technology Progress Award in Pudong New Area in 2018 (First Accomplisher)

Copyright © 2024, All Rights Reserved.