Search

Close
Research
Home > Research > Faculty
Research

YIN Jun  

  • Chief Physician, Doctoral Supervisor, Professor
  • Department: Endocrinology and Metabolism
  • Research Area: Internal Medicine (Endocrinology and Metabolism)
  • Research Interests: Molecular mechanisms and treatment of obesity and diabetes
  • Contact: yinjun@sjtu.edu.cn
Biography Positions Publications Patents
  • Chief Physician, Department of Endocrinology & Metabolism, Shanghai Sixth People's Hospital, 2016
  • Associate Chief Physician, Department of Endocrinology & Metabolism, Shanghai Sixth People's Hospital, 2011
  • Postdoctoral Researcher, Internal Medicine / Cardiology, Virginia Commonwealth University, 2009
  • Postdoctoral Researcher, Pennington Biomedical Research Center, Louisiana State University System, 2005
  • Attending Physician, Department of Endocrinology, Shanghai Second Medical University Affiliated Xinhua Hospital, 2002
  • Resident, Department of Endocrinology, Shanghai Second Medical University Affiliated Xinhua Hospital, 2001
  • M.D., Ph.D. from Shanghai Second Medical University, 2001
  • M.S. from Shanghai University of Traditional Chinese Medicine, 1998
  • Vice President, Jinshan Branch of Shanghai Sixth People's Hospital
  • Associate Chief, Endocrinology Section, Shanghai Association of Chinese Integrative Medicine
  • Director, Shanghai Dietotherapy Research Society
  • Vice Chairman, Low-carbon Medical Technology and Industry section, China Biochemical Pharmaceutical Industry Association
  • Deputy Secretary-General, Obesity Research Branch, Chinese Biophysical Society
  • Committee member, Endocrinology Section, Shanghai Medical Association
  • Member, the Medical Accident Identification Expert Database and the Vaccine Adverse Reaction Identification Expert Database, Shanghai Medical Association
  • Vice Chairman of Vascular Aging Prevention and Treatment Professional, China Primary Health Care Foundation
  • Committee member, Grassroots Chronic Disease Prevention and Treatment Management Branch, China Geriatrics Society
  • Vice Chairman, Xuhui District Endocrinology Association
  • Vice Chairman, Diabetes Section, Shanghai Dietotherapy Research Association
  • Committee member, Chinese Internal Medicine Association
  • Committee member, Insulin Resistance Group, Chinese Diabetes Society
  • Committee member, New Technologies for Diabetes Monitoring and Treatment Group, Chinese Diabetes Society
  • Committee member, Shanghai Diabetes Association
  • Associate Chief, Diabetes Education and Management Group, Shanghai Diabetes Association
  • Committee member, Diabetes Section, Shanghai Association of TCM
  • Vice Chairman, Xuhui District Endocrinology Association
  • Vice Chairman, Diabetes Section, Shanghai Dietotherapy Research Association
  • Committee member, Chinese Internal Medicine Association
  • Committee member, Insulin Resistance Group, Chinese Diabetes Society
  • Committee member, New Technologies for Diabetes Monitoring and Treatment Group, Chinese Diabetes Society
  • Committee member, Shanghai Diabetes Association
  • Associate Chief, Diabetes Education and Management Group, Shanghai Diabetes Association
  • Committee member, Diabetes Section, Shanghai Association of TCM
  1. Cai L, Xia X, Gu Y, Hu L, Li C, Ma X*, Yin J*. Opposite effects of low-carbohydrate high-fat diet on metabolism in humans and mice. Lipids Health Dis,  2023, doi: 10.1186/s12944-023-01956-3.
  2. Xia X, Xu M, Gu Y, Li Y, Li L*, Yin J*. Low-carbohydrate diet in the treatment of type 2 diabetes mellitus (LoCaT): study protocol for a multicenter, randomized controlled trial. Trials. 2023 Jun 19;24(1):411 
  3. Wang W, Wan J, Du W, Song J, Lu Y, Gu S, Feng Y, Wang G, Tao M*, Yin J*. Delayed treatment with nirmatrelvir/ritonavir could remain effective in patients with Omicron BA2.2 variant of COVID-19. Ann Acad Med Singap 2023 Mar;52(3):158-60
  4. Wu Y, Feng Y, Wan J, Du W, Tao M, Gu S, Yin J*. Cycle threshold values are not associated with mortality: Risk factor analysis in older patients with the SARS-CoV-2 Omicron variant. Travel Med Infect Dis, 2023, doi:10.1016/j.tmaid.2023.102555.
  5. Hu L, Xia X, Zong Y, Gu Y, Wei L, Yin J*. Calorie Restriction Enhanced Glycogen Metabolism to Compensate for Lipid Insufficiency. Mol Nutr Food Res. 2022 Oct;66(20):e2200182,doi:10.1002/mnfr.202270050.
  6. Gao F, Li C, Wang Y, Lu J, Lu W, Zhou J, Yin J*, Ma X*. Growth differentiation factor 15 is not associated with glycemic control in patients with type 2 diabetes mellitus treated with metformin: a post-hoc analysis of AIM study. BMC Endocr Disord. 2022 Oct 22;22(1):256,doi: 10.1186/s12902-022-01176-3. 
  7. Song J, Xia X, Lu Y, Wan J, Chen H, Yin J*. Relationship among Insulin Therapy, Insulin Resistance, and Severe Coronary Artery Disease in Type 2 Diabetes Mellitus. J Interv Cardiol. 2022 Sep 26;2022:2450024,doi: 10.1155/2022/2450024.
  8. Hu L, Ma L, Xia X, Ying T, Zhou M, Zou S, Yu H, Yin J*. Efficacy of bariatric surgery in the treatment of women with obesity and polycystic ovary syndrome. J Clin Endocrinol Metab, 2022, doi: 10.1210/clinem/dgac294.
  9. Lingwen Ying#, Yong Zhang#, Jun Yin#, Yufei Wang, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou. Classic Type 1 Diabetes Mellitus and Fulminant Type 1 Diabetes Mellitus: Similarity and Discrepancy of Immunological Characteristics and Cytokine Profile. Diabetes Metab Syndr Obes, 2021, doi: 10.2147/DMSO.S334712.
  10. Ye Lu, Lili Hu, Jing Song, Jing Wan, Haibing Chen, Jun Yin*. Gallstone disease and nonalcoholic fatty liver disease in patients with type 2 diabetes: a cross-sectional study. BMC Endocr Disord, 2021, doi: 10.1186/s12902-021-00899-z.
  11. Cai L#, Yin J#, Ma X, Mo Y, Li C, Lu W, Bao Y, Zhou J, Jia W. Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial. Front Med, 2021, doi: 10.1007/s11684-021-0861-6
  12. Muyu Yu, Miriayi Alimujiang, Lili Hu, Fang Liu, Yuqian Bao, Jun Yin*. Berberine alleviates lipid metabolism disorders via inhibition of mitochondrial complex I in gut and liver. Int J Biol Sci, 2021, doi: 10.7150/ijbs.54604.
  13. Ying L, Zhang M, Ma X, Si Y, Li X, Su J, Yin J*, Bao Y*. Macrophage LAMTOR1 Deficiency Prevents Dietary Obesity and Insulin Resistance Through Inflammation-Induced Energy Expenditure. Front Cell Dev Biol, 2021, doi: 10.3389/fcell.2021.672032.
  14. Lingli Cai, Cheng Li, Yufei Wang, Yifei Mo, Jun Yin*, Xiaojing Ma*. Increased Serum GDF15 Related to Improvement in Metabolism by Lifestyle Intervention Among Young Overweight and Obese Adults. Diabetes Metab Syndr Obes, 2021, doi: 10.2147/DMSO.S302033.
  15. Linlin Ji, Qianqian Wang, Mengdan Liu, Chaoyu Zhu, Yuanyuan Xiao, Junfeng Han, Yunyun Fang, Jianping Ye, Jun Yin*, Li Wei*. The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic gluconeogenesis through interacting with the glucagon receptor and FOXO1. FEBS Lett, 2021, doi: 10.1002/1873-3468.14063.
  16. Zhao WJ, Xia XY, Yin J*. Relationship of serum vitamin D levels with diabetic microvascular complications in patients with type 2 diabetes mellitus. Chinese Medical Journal, 2021, doi: 10.1097/CM9.0000000000001364.
  17. Fang YY, Ji LL, Zhu CY, Xiao YY, Zhang JJ, Lu JX, Yin J* and Wei L*. Liraglutide Alleviates Hepatic Steatosis by Activating the TFEB-regulated Autophagy-lysosomal Pathway. Front Cell Dev Biol, 2020, doi: 10.3389/fcell.2020.602574.
  18. Xiao Y, Xu M, Alimujiang M, Bao Y, Wei L*, Yin J*. Bidirectional regulation of adenosine 5' - monophosphate - activated protein kinase activity by berberine and metformin in response to changes in ambient glucose concentration. J Cell Biochem, 2018, doi: 10.1002/jcb.27312.
  19. Ying LW, Ma XJ, Yin J*, Wang YF, He XX, Peng JH, Bao YQ, Zhou J, Jia WP. The metabolism and transport of 1,5-anhydroglucitol in cells. Acta Diabetol, 2018, doi: 10.1007/s00592-017-1093-8.
  20. Hou WL, Yin J*, Alimujiang M, Yu XY, Ai LG, Bao YQ, Liu F, Jia WP. Inhibition of mitochondrial complex I improves glucose metabolism independently of AMPK activation. J Cell Mol Med, 2018, doi: 10.1111/jcmm.13432.
  21. Su H, Ma X, Yin J*, Wang Y, He X, Bao Y, Zhou J, Jia W. Serum 1,5-anhydroglucitol levels slightly increase rather than decrease after a glucose load in subjects with different glucose tolerance status. Acta Diabetol, 2017, doi: 10.1007/s00592-017-0968-z.
  22. Xu M, Xiao Y, Yin J*, Hou W, Yu X, Shen L, Liu F, Wei L, Jia W. Berberine promotes glucose consumption independently of AMP-activated protein kinase activation. PLoS One, 2014, doi: 10.1371/journal.pone.0103702.
  23. Yin J, Lee JH, Zhang J, Gao Z, Polotsky VY, Ye J. Regulation of hepatocyte growth factor expression by NF-κB and PPARγ in adipose tissue. Am J Physiol Endocrinol Metab, 2014, doi: 10.1152/ajpendo.00687.2013.
  24. Yin J, Zhang F, Zhang H, Shen L, Li Q, Hu S, Tian Q, Bao Y, Jia W. Hand-Schüller-Christian disease and Erdheim-Chester disease: coexistence and discrepancy. Oncologist, 2013, doi: 10.1634/theoncologist.2012-0234.
  25. Xu F, Gao Z, Zhang J, Rivera CA, Yin J, Weng J, Ye J: Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation. Endocrinology, 2010, doi: 10.1210/en.2009-1013.
  26. Tang T, Zhang J, Yin J, Staszkiewicz J, Gawronska-Kozak B, Jung DY, Ko HJ, Ong H, Kim JK, Mynatt R, Martin RJ, Keenan M, Gao Z, Ye J: Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure. J Biol Chem, 2010, doi: 10.1074/jbc.M109.068007.
  27. Niimi M, Tao L, Lin SH, Yin J, Wu X, Fukui H, Kambayashi J, Ye J, and Sun B. Involvement of an alternatively spliced mitochondrial oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells. J Biomed Sci, 2009, DOI: 10.1186/1423-0127-16-92.
  28. Gao Z, Yin J, Zhang J, He Q, McGuinness OP, Ye J.Inactivation of NF-κB P50 leads to insulin sensitization in liver through post-translational inhibition of P70S6K. J Biol Chem, 2009, doi: 10.1074/jbc.M109.007260.
  29. Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J. Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice. Diabetes, 2009, doi: 10.2337/db08-1637.
  30. Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Ye J. Shilianhua extract inhibits GSK-3β and promotes glucose metabolism. Am J Physiol Endocrinol Metab, 2009, doi: 10.1152/ajpendo.00092.2009.
  31. Yin J, Zhanguo G, He Q, Zhou D, Guo Z, Ye J. Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab., 2009, doi: 10.1152/ajpendo.90760.2008.
  32. Zhang J, Gao Z, Yin J, Quon MJ, Ye J. S6K directly phosphorylates IRS-1 on Ser270 to promote insulin resistance in response to TNF-alpha signaling through IKK2. J Biol Chem, 2008, doi: 10.1074/jbc.M806480200.
  33. Yin J, Zuberi A, Gao Z, Liu D, Liu Z, Cefalu W, Ye J. Effect of Shilianhua extract and its fractions on body weight of obese mice. Metabolism, 2008, doi: 10.1016/j.metabol.2008.03.004.
  34. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes. Metabolism,doi: 10.1016/j.metabol.2008.01.013.
  35. Yin J, Gao Z, Liu D, Liu Z, Ye J. Berberine improves glucose metabolism through induction of glycolysis. Am J Physiol Endocrinol Metab, 2008, doi: 10.1152/ajpendo.00211.2007.
  36. Pang C, Gao Z, Yin J, Zhang J, Jia W, Ye J. Macrophage Infiltration into Adipose Tissue May Promote Angiogenesis for Adipose Tissue Remodeling in Obesity,Am J Physiol Endocrinol Metab, 2008, doi: 10.1152/ajpendo.90296.2008.
  37. Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab, 2007, doi: 10.1152/ajpendo.00435.2007.
  38. Dong Y, Sheng H, Chen X, Yin J, Su Q. Deletion of the V2 vasopressin receptor gene in two Chinese patients with nephrogenic diabetes insipidus. BMC Genet, 2006, doi: 10.1186/1471-2156-7-53.
  39. Yin J, Hu R, Chen M, Tang J, Li F, Yang Y, Chen J. Effects of berberine on glucose metabolism in vitro. Metabolism, 2002, doi: 10.1053/meta.2002.34715.
  1. [Jun Yin, Wolin Hou] (2017), “The application of rotenone in the preparation of hypoglycemic drugs”, CN104997768A; ZL 201510439208.8

Copyright © 2024, All Rights Reserved.