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Research

XU Tao  

  • Chief Physician, Doctoral Supervisor, Professor
  • Department: Anesthesiology
  • Research Area: Anesthesiology
  • Research Interests: Brain mechanisms of general anesthesia, Spinal mechanisms of opioid tolerance, inflammatory pain, and neuropathic pain
  • Contact: balor@sjtu.edu.cn
Biography Positions Publications Other
  • Visiting Scholar, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 2016
  • Visiting Scholar, The Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School,2011
  • MD from Shanghai Jiao Tong University School of Medicine, 2009
  • Bachelor of Medicine from Southeast University School of Medicine, 2004
  • Deputy Director, Department of Anesthesiology, Shanghai Sixth People's Hospital
  • Deputy Leader, Youth Group of Anesthesiology Society of Chinese Medical Association
  • Member, Anesthesiology Branch of Shanghai Medical Association
  • Young Deputy Chairman, Pain Branch of Shanghai Medical Association
  • Standing Committee member, Acupuncture Anesthesia Branch of Chinese Acupuncture and Moxibustion Society
  • Standing Committee member, Anesthesia Pharmacology Branch of Chinese Pharmacological Society
  • Member and Secretary, Regional Anesthesiology Branch of China International Exchange and Promotion Association for Medical and Health Care
  • Member, Youth Innovation Working Committee of Shanghai Neuroscience Society
  • Member, Brain Function Measurement and Regulation  branch of Shanghai Association of Rehabilitation Medicine
  • Standing Committee member, Addiction and Brain Function Branch of Chinese Association for Drug Abuse Prevention and Control
  1. Wang WY, Ma XQ, Du WJ, Lin RZ, Li ZP, Jiang W, Wang LY, Worley PF, Xu T*. Small G-Protein Rheb gates mTOR signaling to regulate morphine tolerance in mice. Anesthesiology, 2023, doi: 10.1097/ALN.0000000000004885.
  2. Zhu XN, Li J, Qiu GL, Wang L, Lu C, Guo YG, Yang KX, Cai F, Xu T*, Yuan TF, Hu J. Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter. Neuron. 2023, doi: 10.1016/j.Neuron.2023.02.017.
  3. Xu X, Wu K, Ma X, Wang W, Wang H, Huang M, Luo L, Su C, Yuan T, Shi H, Han J, Wang A, Xu T. mGluR5-Mediated eCB Signaling in the Nucleus Accumbens Controls Vulnerability to Depressive-Like Behaviors and Pain After Chronic Social Defeat Stress. Mol Neurobiol, 2021, doi: 10.1007/s12035-021-02469-9. 
  4. Li FL, Li YQ, Zheng H, Jiang L, Gao DR, Li CB, Peng YH, Cao ZH, Zhang YS, Yao DZ, Xu T, Yuan TF, Xu P.Identification of the General Anesthesia Induced Loss of Consciousness by Cross Fuzzy Entropy-Based Brain Network. IEEE Trans Neural Syst Rehabil Eng, 2021, https://doi.org/10.1016/j.ijpsycho.2021.07.604
  5. Shi Z, Qin M, Huang L, Xu T, Chen Y, Hu Q, Peng S, Peng Z, Qu LN, Chen SG, Tuo QH, Liao DF, Wang XP, Wu RR, Yuan TF, Li YH, Liu XM. Human torpor: translating insights from nature into manned deep space expedition. Biol Rev Camb Philos Soc, 2021, doi: 10.1111/brv.12671.
  6. Wang H, Huang M, Wang W, Zhang Y, Ma X, Luo L, Xu X, Xu L, Shi H, Xu Y, Wang A, Xu T. Microglial TLR4-induced TAK1 phosphorylation and NLRP3 activation mediates neuroinflammation and contributes to chronic morphine-induced antinociceptive tolerance. Pharmacol Res, 2021, doi: 10.1016/j.phrs.2021.105482. 
  7. Dong J, Zhang Y, Chen X, Ni W, Yan H, Liu Y, Shi H, Jiang W, Zhao D, Xu T. Ultrasound-guided anterior iliopsoas muscle space block versus posterior lumbar plexus block in hip surgery in the elderly: A randomised controlled trial. Eur J Anaesthesiol, 2021, doi: 10.1097/EJA.0000000000001452. 
  8. Ma X, Du W, Wang W, Luo L, Huang M, Wang H, Lin R, Li Z, Shi H, Yuan T, Jiang W, Worley PF, Xu T. Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain. Cell Death Dis, 2020, doi: 10.1038/s41419-020-02966-0.
  9. Yuan L, Luo L, Ma X, Wang W, Yu K, Shi H, Chen J, Chen D, Xu T. Chronic morphine induces cyclic adenosine monophosphate formation and hyperpolarization-activated cyclic nucleotide-gated channel expression in the spinal cord of mice. Neuropharmacology, 2020, doi: 10.1016/j.neuropharm.2020.108222.
  10. Luo L, Huang M, Zhang Y, Wang W, Ma X, Shi H, Worley PF, Kim DK, Fedorovich SV, Jiang W, Xu T. Disabling phosphorylation at the homer ligand of the metabotropic glutamate receptor 5 alleviates complete Freund's adjuvant-induced inflammatory pain. Neuropharmacology, 2020, doi: 10.1016/j.neuropharm.2020.108046.
  • Third prize of Hospital Science and Technology Innovation Award of China Hospital Association

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