Research
Search
Close
WANG Zhigang
- Chief Physician, Doctoral Supervisor
- Department: General Surgery
- Research Area: Surgery (General Surgery)
- Research Interests: Surgical treatment of colorectal cancer recurrence and metastasis, and related clinical and basic research.
- Contact: wangzhigang72@sjtu.edu.cn
- PhD from Fudan University, 2003
- M.A. from Shandong University, 1997
- Bachelor's Degree from Shandong University, 1994
- Chief Physician, Department of General Surgery, Shanghai Sixth People's Hospital
- Bai Y, Li T, Wang Q, You W, Yang H, Xu X, Li Z, Zhang Y, Yan C, Yang L, Qiu J, Liu Y, Chen S, Wang D, Huang B, Liu K, Song BL, Wang Z, Li K, Liu X, Wang G, Yang W, Chen J, Hao P, Zhang Z, Wang Z, Zhu ZJ, Xu C. Shaping immune landscape of colorectal cancer by cholesterol metabolites. EMBO Mol Med. 2024 Feb;16(2):334-360. doi: 10.1038/s44321-023-00015-9. Epub 2024 Jan 2.
- Zhou S, He Q, Sheng N, Gong J, Ren J, Wang Z*. Blood cholesterol-to-lymphocyte ratio as a novel prognostic marker to predict postoperative overall survival in patients with colon cancer. World J Surg Oncol. 2022 Jan 15;20(1):18. doi: 10.1186/s12957-021-02471-4.
- Yu Z, Lin S, Xia F, Liu Y, Zhang D, Wang F, Wang Y, Li Q, Niu J, Cao C, Cui D, Sheng N, Ren J, Wang Z*, Chen D*. ExoSD chips for high-purity immunomagnetic separation and high-sensitivity detection of gastric cancer cell-derived exosomes. Biosens Bioelectron. 2021 Dec 15;194:113594. doi: 10.1016/j.bios.2021.113594. Epub 2021 Aug 27.
- Sheng N, Yan L, Wu K, You W, Gong J, Hu L, Tan G, Chen H, Wang Z. TRIP13 promotes tumor growth and is associated with poor prognosis in colorectal cancer. Cell Death Dis. 2018 Mar 14;9(3):402. doi: 10.1038/s41419-018-0434-z.
- Yan L, You W, Sheng N, Gong J, Hu L, Tan G, Chen H*, Wang Z*. A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colon cancer. Aging (Albany NY). 2018 Dec 6;10(12):3774-3793. doi: 10.18632/aging.101671.
- You W, Sheng N, Yan L, Chen H, Gong J, He Z, Zheng K, Chen Z, Wang Y, Tan G*, Xie L*, Wang Z*. The difference in prognosis of stage II and III colon cancer based on preoperative serum tumor markers. J Cancer. 2019 Jun 9;10(16):3757-3766. doi: 10.7150/jca.31660.
- Wu Z, Han X, Tan G, Zhu Q, Chen H, Xia Y, Gong J, Wang Z*, Wang Y*, Yan J*. Dioscin Inhibited Glycolysis and Induced Cell Apoptosis in colon cancer via Promoting c-myc Ubiquitination and Subsequent Hexokinase-2 Suppression. Onco Targets Ther. 2020 Jan 6;13:31-44. doi: 10.2147/OTT.S224062.
- Lin S, Yu Z, Chen D, Wang Z, Miao J, Li Q, Zhang D, Song J, Cui D. Progress in Microfluidics-Based Exosome Separation and Detection Technologies for Diagnostic Applications. Small. 2020 Mar;16(9):e1903916. doi: 10.1002/smll.201903916. Epub 2019 Oct 30.
- 07/01/2021-06/30/2024
Shanghai Jiaotong University School of Medicine, ¥1,000,000, 20172023
Computational biology was used to establish a mathematical model for the early warning of recurrence and metastasis of colorectal cancer
Role: Project leader - 10/01/2020-09/30/2022
Shanghai Shenkang Development Center, ¥900,000, SHDC2020CR1033B-003
A prospective multicenter study of conversion therapy in patients with RAS/BRAF wild-type unresectable right colon cancer with liver metastases
Role: Principal Investigator
- [Zhigang Wang, Siyu Zhou] (2021), “Clinical prediction of colorectal cancer DNA mismatch repair system (MMR) status Model software V1.0”, 2021SR1089263
- [Zhigang Wang] (2019), “Accurate model software for colorectal cancer survival assessment(CRCPM) V1.0”, 2020SR0101826
- [Zhigang Wang] (2019), “Accurate model software for risk prediction and survival assessment of gastric cancer recurrence(GCPM) V1.0”, 2020SR0088927
