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WANG Xiuzhe  

  • Graduate Supervisor, Associate Professor
  • Department: Neurology
  • Research Area: Neurology
  • Research Interests: Dementia, Stroke, Neurodegeneration, Neuroinflammation, Neuroimmunology
  • Contact: xiuzhewang@hotmail.com
Biography Positions Publications
  • MD from Jilin University School of Medicine, 2006
  • PhD from Karolinska Institutet, 2014
  • Member of Dementia Research Committee, Shanghai Medical Asscoiation
  • Member of Youth Committee, Shanghai Stroke Asscoiation
  • Member of Neurology Committee, Shanghai Stroke Asscoiation
  • Member of Neuro-rehabilitation Committee, Shanghai Stroke Asscoiation
  • Member of Neuro-rehabilitation Committee, Shanghai Association of Rehabilitation Medicine
  • Member of Dementia Research Committee, Chinese Geriatrics Society
  1. Liu L, Zhang J, Lu K, Zhang Y, Xu X, Deng J, Zhang X, Zhang H, Zhao Y, Wang X. ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke. Journal of Translational Medicine. 2024 Jan 4;22(1):23. 
  2. Wang L, Zhang X, Zhang H, Lu K, Li M, Li X, Ou Y, Zhao X, Wu X, Wu X, Liu J, Xing M, Liu H, Zhang Y, Tan Y, Li F, Deng X, Deng J, Zhang X, Li J, Zhao Y, Ding Q, Wang H, Wang X*, Luo Y*, Zhou B*, Zhang H*. Excessive apoptosis of Rip1-deficient T cells leads to premature aging. EMBO Reports. 2023 Dec 6;24(12):e57925.
  3. Zhang Y, Zhang J, Zhao Y, Zhang Y, Liu L, Xu X, Wang X*, Fu J*. ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis. Cell Death and Disease. 2023 Nov 6;14(11):721. 
  4. Zhang J, Liu L, Zhang Y, Yuan Y, Miao Z, Lu K, Zhang X, Ni R, Zhang H, Zhao Y*, Wang X*. ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation. Redox Biology. 2022 Nov 24;58:102554. 
  5. Chen F, Zhang L, Bai X, Wang X*, Geng Z*. Clinical Application of Thromboelastography in Acute Ischemic Stroke. Clinical and Applied Thrombosis-Hemostasis. 2022 Dec;28:10760296221131801. 
  6. Tang X, Liu L, Miao Z, Zhang J, Cai X, Zhao BQ, Chen G, Schultzberg M, Zhao Y*, Wang X*. Resolution of inflammation is disturbed in acute ischemic stroke with diabetes mellitus and rescued by resolvin D2 treatment. Free Radical Biology and Medicine. 2022 Aug 1;188:194-205. 
  7. Zhao Y, Zhang J, Zhang Y, Zhang Y, Zhang X, Zheng Y, Wang H, Wang X*, Fu J*. Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment. International Immunopharmacology. 2022 Jul;108:108756.
  8. Zhang J, Zhang Y, Yuan Y, Liu L, Zhao Y* and Wang X*. Gut microbiota alteration is associated with cognitive deficits in genetically diabetic (db/db) mice during aging. Frontiers in Aging Neuroscience. 2022 Jan; 13:815562.
  9. Zhao Y, Zhang J, Zheng Y, Zhang Y, Zhang XJ, Wang H, Du Y, Guan J, Wang X*, Fu J*. NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway. Journal of Neuroinflammation. 2021 Sep 16;18(1):207.
  10. Wang X, Miao Z, Xu X, Schultzberg M, Zhao Y*. Reduced levels of plasma lipoxin A4 are associated with post-stroke cognitive impairment. Journal of Alzheimer’s Disease. 2021;79(2):607-613.
  11. Zhang J, Zheng Y, Zhao Y, Zhang Y, Liu Y, Ma F, Wang X*, Fu J*. Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice. International Immunopharmacology. 2021 Jul;96:107808. 
  12. Miao Z, Tang X, Schultzberg M, Zhao Y*, Wang X*. Plasma resolvin D2 to leukotriene B4 ratio is reduced in diabetic patients with ischemic stroke and related to prognosis. Biomed Research International. 2021 Feb 26;2021:6657646.
  13. Miao Z, Schultzberg M, Wang X*, Zhao Y*. Role of polyunsaturated fatty acids in ischemic stroke - A perspective of specialized pro-resolving mediators. Clinical Nutrition. 2021 May;40(5):2974-2987.
  14. Lu J#, Wang X#, Wan L, Fu J, Huo Y, Zhao Y*, Guo C*. Gene polymorphisms affecting the pharmacokinetics and pharmacodynamics of donepezil efficacy. Frontiers in Pharmacology. 2020 Jun 19;11:934.
  15. Zhu M#*, Wang X#, Sun L, Schultzberg M, Hjorth E*. Can inflammation be resolved in Alzheimer's disease? Therapeutic Advances in Neurological Disorders. 2018 Aug 9;11:1756286418791107.
  16. Wang X, Zhu M, Hjorth E, Cortés-Toro V, Eyjolfsdottir H, Graff C, Nennesmo I, Palmblad J, Eriksdotter M, Sambamurti K, Fitzgerald JM, Serhan CN, Granholm AC, Schultzberg M*. Resolution of inflammation is altered in Alzheimer’s disease. Alzheimer's & Dementia. 2015 Jan;11(1):40-50.e2.
  17. Wang X*, Hjorth E, Vedin I, Eriksdotter M, Freund-Levi Y, Wahlund LO, Cederholm T, Palmblad J, Schultzberg M. Effects of n-3 fatty acid supplementation on the release of pro-resolving lipid mediators by blood mononuclear cells: the OmegAD study. Journal of Lipid Research. 2015 Mar;56(3):674-81.
  18. 18.    Wang X, Puerta E, Cedazo-Minguez A, Hjorth E, Schultzberg M*. Insufficient resolution response in the hippocampus of a senescence-accelerated mouse model - SAMP8. Journal of Molecular Neuroscience. 2015 Feb;55(2):396-405.

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