Search

Close
Research
Home > Research > Faculty
Research

WANG Jian  

  • Doctoral Supervisor, Professor
  • Department: General Surgery
  • Research Area: Surgery (General Surgery)
  • Research Interests: Pathogenesis of biliary tract carcinomas
  • Contact: dr_wangjian@126.com
Biography Positions Publications Research Projects Patents
  • Visiting Scholar, Mayo Clinic, 2013
  • Visiting Scholar, The Johns Hopkins Hospital, 2006
  • MD, PhD from Shanghai Second Medical University, 2001
  • Bachelor of Medicine from Shanghai Second Medical University, 1993
  • Committee Member, Biliary Surgery Branch, Surgery Society of Chinese Medical Association
  • Vice Chairman, Biliary Surgery Professional Committee, Surgeons College of Chinese Medical Doctor Association
  • Vice Chairman, Minimally Invasive Pancreatic Surgery Branch, Chinese Anti-Cancer Association
  • Committee Member, Division of Neuroendocrine Tumor, Society of Pancreatic Tumor, Chinese Anti-Cancer Association
  • Vice Chairman, Surgery Branch, Shanghai Association of Chinese Integrative Medicine
  • Board of Director Members, Perioperative Branch, Shanghai Association of Chinese Integrative Medicine
  • Vice Chairman, Biliary Surgery Branch, Surgery Society of Shanghai Medical Association
  • Vice Chairman, Hernia and Abdominal wall Branch, Surgery Society of Shanghai Medical Association
  • Committee Member, General Surgery Branch, Surgery Society of Shanghai Medical Association
  • Chairman, Biliary Branch, Shanghai Society of Cancer
  1. Yang C, Shao Y, Wang X, et al. The Effect of the Histone Chaperones HSPA8 and DEK on Tumor Immunity in Hepatocellular Carcinoma. Int J Mol Sci, 2023;24(3):2653.
  2. Wang W, Yang C, Wang J, et al. Hepatolithiasis Classification Based on Anatomical Hepatectomy. J Gastrointest Surg. 2023;27(5):914-925..
  3. Wang W, Yang CX, Yu XZ, et al. Clinicopathological characteristics and prognostic factors of patients with primary gallbladder neuroendocrine carcinomas. J Dig Dis. 2022;23(3):166-173.
  4. Wang W, Wang J, Yang C, Wang J. MicroRNA-216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer-A transcriptome analysis. IUBMB Life. 2021;73(6):866-882.
  5. Zhang J, Fu X, Liu D, et al. Molecular markers associated with perineural invasion in pancreatic ductal adenocarcinoma. Oncol Lett. 2020;20(4):5.
  6. Yang D, Chen T, Zhan M, et al. Modulation of mTOR and epigenetic pathways as therapeutics in gallbladder cancer. Mol Ther Oncolytics. 2020;20:59-70.
  7. Wang W, Zhang Z, Wang J. Subtotal (segment II-VIII) hepatectomy for bilateral diffuse hepatolithiasis with compensatory caudate lobe hypertrophy: a report of two cases. BMC Gastroenterol. 2020;20(1):350.
  8. Huang S, Wang H, Chen W, et al. Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer. J Cell Mol Med. 2020;24(2):1599-1613. 
  9. Zhang Y, Wang H, Chen T, et al. C24-Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5-Phosphate 4-Kinase Type-2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation. Hepatology. 2021;73(2):692-712.
  10. Yan J, Feng H, Wang H, et al. Hepatic artery classification based on three-dimensional CT. Br J Surg. 2020;107(7):906-916.
  11. Lin R, Zhan M, Yang L, et al. Deoxycholic acid modulates the progression of gallbladder cancer through N6-methyladenosine-dependent microRNA maturation. Oncogene. 2020;39(26):4983-5000.
  12. Wang H, Zhan M, Liu Q, Wang J. Glycochenodeoxycholate promotes the metastasis of gallbladder cancer cells by inducing epithelial to mesenchymal transition via activation of SOCS3/JAK2/STAT3 signaling pathway. J Cell Physiol. 2020;235(2):1615-1623.
  13. Chen T, Tu S, Wang H, et al. Computer-aided diagnosis of gallbladder polyps based on high resolution ultrasonography. Comput Methods Programs Biomed. 2020;185:105118.
  14. Feng H, Tong H, Yan J, He M, Chen W, Wang J. Genomic Features and Clinical Characteristics of Adolescents and Young Adults With Cholangiocarcinoma. Front Oncol. 2020;9:1439.
  15. Xu S, Zhan M, Jiang C, et al. Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer. Nat Commun. 2019;10(1):5492.
  16. He M, Xu X, Feng H, et al. Regional lymphadenectomy vs. extended lymphadenectomy for hilar cholangiocarcinoma (Relay-HC trial): study protocol for a prospective, multicenter, randomized controlled trial. Trials. 2019;20(1):528.
  17. Zhang Y, Liu Y, Duan J, et al. Cholesterol depletion sensitizes gallbladder cancer to cisplatin by impairing DNA damage response. Cell Cycle. 2019;18(23):3337-3350.
  18. Huang X, He M, Huang S, et al. Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription. Mol Cancer. 2019;18(1):166.
  19. Zhan M, Wang H, Xu SW, et al. Variants in oxidative stress-related genes affect the chemosensitivity through Nrf2-mediated signaling pathway in biliary tract cancer. EBioMedicine. 2019;48:143-160.
  20. Shen H, He M, Lin R, et al. PLEK2 promotes gallbladder cancer invasion and metastasis through EGFR/CCL2 pathway. J Exp Clin Cancer Res. 2019;38(1):247.
  21. Wang H, Zhan M, Yang R, Shi Y, Liu Q, Wang J. Elevated expression of NFE2L3 predicts the poor prognosis of pancreatic cancer patients. Cell Cycle. 2018;17(17):2164-2174.
  22. Liu L, Xu HX, He M, et al. A novel scoring system predicts postsurgical survival and adjuvant chemotherapeutic benefits in patients with pancreatic adenocarcinoma: Implications for AJCC-TNM staging. Surgery. 2018;163(6):1280-1294.
  23. Shen H, Zhan M, Zhang Y, et al. PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2. Cell Death Dis. 2018;9(2):71.
  24. Zhan M, Yang RM, Wang H, et al. Guided chemotherapy based on patient-derived mini-xenograft models improves survival of gallbladder carcinoma patients. Cancer Commun (Lond). 2018;38(1):48.
  25. Liu XS, Chen T, Gu LH, et al. Ultrasound-based scoring system for differential diagnosis of polypoid lesions of the gallbladder. J Gastroenterol Hepatol. 2018;33(6):1295-1299.
  26. Long M, Zhan M, Xu S, et al. miR-92b-3p acts as a tumor suppressor by targeting Gabra3 in pancreatic cancer. Mol Cancer. 2017;16(1):167.
  27. Yang D, Zhan M, Chen T, et al. miR-125b-5p enhances chemotherapy sensitivity to cisplatin by down-regulating Bcl2 in gallbladder cancer. Sci Rep. 2017;7:43109.
  28. He M, Zhan M, Chen W, et al. MiR-143-5p Deficiency Triggers EMT and Metastasis by Targeting HIF-1α in Gallbladder Cancer. Cell Physiol Biochem. 2017;42(5):2078-2092.
  29. Wang H, Zhan M, Xu SW, et al. miR-218-5p restores sensitivity to gemcitabine through PRKCE/MDR1 axis in gallbladder cancer. Cell Death Dis. 2017;8(5):e2770.
  30. Xu S, Zhan M, Wang J. Epithelial-to-mesenchymal transition in gallbladder cancer: from clinical evidence to cellular regulatory networks. Cell Death Discov. 2017;3:17069.
  31. Yang RM, Zhan M, Xu SW, et al. miR-3656 expression enhances the chemosensitivity of pancreatic cancer to gemcitabine through modulation of the RHOF/EMT axis. Cell Death Dis. 2017;8(10):e3129.
  32. Zhan M, Zhao X, Wang H, et al. miR-145 sensitizes gallbladder cancer to cisplatin by regulating multidrug resistance associated protein 1. Tumour Biol. 2016;37(8):10553-10562.
  33. Li Q, Yin X, Wang W, et al. The effects of buthionine sulfoximine on the proliferation and apoptosis of biliary tract cancer cells induced by cisplatin and gemcitabine. Oncol Lett. 2016;11(1):474-480.
  34. Chen T, Zhang YH, Wang HL, et al. Late-onset Deep Mesh Infection: A Study of Eight Cases Detected from 2666 Consecutive Patients with Abdominal Wall Hernia Repairs. Chin Med J (Engl). 2016;129(15):1870-1872.
  35. Wang W, Zhan M, Li Q, et al. FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression. Oncotarget. 2016;7(23):34617-34629.
  36. Shen H, Zhan M, Wang W, et al. Impact of diabetes mellitus on the survival of pancreatic cancer: a meta-analysis. Onco Targets Ther. 2016;9:1679-1688.
  37. Li Q, Zhan M, Chen W, et al. Phenylethyl isothiocyanate reverses cisplatin resistance in biliary tract cancer cells via glutathionylation-dependent degradation of Mcl-1. Oncotarget. 2016;7(9):10271-10282.
  38. Zhan M, Wang H, Chen T, et al. NOX1 mediates chemoresistance via HIF1α/MDR1 pathway in gallbladder cancer. Biochem Biophys Res Commun. 2015, 468(1-2): 79-85. 
  39. Yang L, Wang H, Liang X, et al. Bacteria in hernia sac: an important risk fact for surgical site infection after incarcerated hernia repair. Hernia. 2015, 19(2): 279-83.
  40. Wang W, Chen W, Li KW, et al. Upper gastrointestinal hemorrhage due to a fistula between the splenic vein and main pancreatic duct: a rare case. J Dig Dis. 2015, 16(4): 241-244.
  41. Wang W, Yin X, Li G, et al. Expressions of farnesoid X receptor and myeloid cell leukemia sequence 1 protein are associated with poor prognosis in patients with gallbladder cancer. Chin Med J (Engl), 2014,127(14): 2637-2642. 
  42. Wang H, Wang H, Chen T, et al. Evaluation of the POSSUM, P-POSSUM and E-PASS scores in the surgical treatment of hilar cholangiocarcinoma. World J Surg Oncol, 2014, 12(191). 
  43. Chen T, Wang H, Wang H, et al. POSSUM and P-POSSUM as predictors of postoperative morbidity and mortality in patients undergoing hepato- biliary-pancreatic surgery: a meta-analysis. Ann Surg Oncol. 2013, 20 (8): 2501-2510.
  44. Wang H, Chen T, Wang H, et al. A systematic review of the Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity and its Portsmouth modification as predictors of post-operative morbidity and mortality in patients undergoing pancreatic surgery. Am J Surg. 2013, 205(4): 466-472.
  45. Wang H, Li X, Chen T, et al. The mechanisms of verapamil-enhanced chemosensitivity of gallbladder cancer cells to platinum drugs: glutathion reduction and MRP1 downregulation. Oncol Rep. 2013, 29(2): 676-684.
  46. Dai J, Wang H, Dong Y, et al. Bile acids affect the growth of human cholangiocarcinoma via NF-kB pathway. Cancer Invest. 2013, 31(2): 111-120.
  47. Li XX, Dong Y, Wang W, et al. Emodin as an effective agent in targeting cancer stem-like side population cells of gallbladder carcinoma. Stem Cells Dev. 2013,22(4): 554-566.
  48. Li XX, Wang J, Wang HL, et al. Characterization of cancer stem-like cells derived from a side population of a human gallbladder carcinoma cell line, SGC-996. Biochem Bioph Res Co. 2012, 419(4): 728-734.
  49. Wang H, Li K, Wang J. Sclerosing angiomatoid nodular transformation (SANT) of the spleen: report of five cases and review of literature. Chinese Med J. 2012, 125(13): 2386-2389.
  50. He M, Wang Y, Shi WJ, et al. Immunomodulation of inducible co-stimulator (ICOS) in human cytokine-induced killer cells against cholangiocarcinoma through ICOS/ICOS ligand interaction. J Digest Dis. 2011, 12(5): 393-400.
  51. Wang W, Sun Y, Li X, et al. Emodin potentiates the anticancer effect of cisplatin on gallbladder cancer cells through the generation of reactive oxygen species and the inhibition of survivin expression. Oncol Rep. 2011, 26(5): 1143-1148.
  52. Dai J, Wang H, Shi Y, et al. Impact of bile acids on the growth of human cholangiocarcinoma via FXR. J Hematol Oncol 2011, 4:41.
  53. Wang W, Sun YP, Huang XZ, et al. Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation. Biochem Pharmacol. 2010, 79(8): 1134-1140.
  54. Wang J, Shi YQ, Wu ZY. A case report of neck, chest and upper limb cutaneous metastasis from synchronous colorectal cancer. Chinese Med J. 2009, 122(14): 1716-1717.
  55. Wang J, He M, Shi W, et al. Inducible costimulator (ICOS) enhances the cytolytic activity of cytokine-induced killer cells against gallbladder cancer in vitro and in vivo. Cancer Invest. 2009, 27(3): 244-250.
  56. Wang J, Shi YQ, Yi J, et al. Suppression of growth of pancreatic cancer cell and expression of vascular endothelial growth factor by gene silencing with RNA interference. J Digest Dis. 2008, 9(4): 228-237.
  • 01/01/2023-12/31/2026
    National Natural Science Foundation of China, ¥520,000, 82273411
    The mechanisms of p53 phosphorylation by WNK1 to promote the invasion and metastasis of gallbladder cancer
    Role: Project leader
  • 01/01/2020-12/31/2023
    National Natural Science Foundation of China, ¥550,000, 81974370
    Loss of ELP5 inhibits IRES-dependent translation of p53 protein to promote chemoresistance in gallbladder cancer
    Role: Project leader
  • 01/01/2018-12/31/2021
    National Natural Science Foundation of China, ¥550,000, 81773184
    The mechanisms of LDHA phosphorylation by CDK4 to enhance chemoresistance through elevating glycolysis in gallbladder cancer
    Role: Project leader
  • 01/01/2015-12/31/2018
    National Natural Science Foundation of China, ¥700,000, 81472240
    The mechanisms of tyrosine phosphorylation related-mutations in Nrf2 Neh3 domain affecting chemotherapy sensitivity of gallbladder cancer
    Role: Project leader
  • 01/01/2013-12/31/2016
    National Natural Science Foundation of China, ¥600,000, 81272748
    The mechanisms of Nrf2 regulation of ROS and ABCG2 on chemosensitivity of gallbladder cancer lateral group cells
    Role: Project leader
  • 01/01/2011-12/31/2013
    National Natural Science Foundation of China, ¥320,000, 81072011
    The mechanisms of MCL1 protein glutathione modification on chemotherapy sensitivity of gallbladder cancer
    Role: Project leader
  • 01/01/2013-12/31/2015
    National Ministry of Science and Technology Support Program, ¥800,000, 2012BAI06B01
    Construction and evidence-based evaluation of a precise hepatobiliary surgery technology system
    Role: Project leader
  • 07/01/2016-09/30/2019
    Project of Shanghai Municipal Commission of Science and Technology, ¥500,000, 16411952700
    Study on the Precision Surgical Technology System of Perihepatic Portal to Improve the Safety and Efficacy of Perihepatic Portal Biliary Tumor Surgery
    Role: Project leader
  • 07/01/2014-09/30/2017
    Project of Shanghai Municipal Commission of Science and Technology, ¥300,000, 14DZ1941309
    Demonstration application of domestically produced endoscopic stapler in gastric and intestinal surgery
    Role: Project leader
  • 07/01/2010-09/30/2013
    Project of Shanghai Municipal Commission of Science and Technology, ¥200,000, 10411955400
    Establishment of a database and surgical evaluation system for hilar cholangiocarcinoma
    Role: Project leader
  • 07/01/2009-06/30/2011
    Project of Shanghai Municipal Commission of Science and Technology, ¥100,000, 09411960800
    Mechanism study on the influence of reactive oxygen species levels in SP cells on drug resistance in gallbladder cancer
    Role: Project leader
  • 07/01/2007-06/30/2009
    Project of Shanghai Municipal Commission of Science and Technology, ¥100,000, 07ZR14073
    The effect of bile acid signaling pathway on NF-KB activity and biological behavior of cholangiocarcinoma
    Role: Project leader
  • 12/01/2016-06/30/2019
    Project of Shanghai Shenkang Hospital Development Center, ¥800,000, 16CR2002A
    A prospective, randomized controlled clinical study of genomics based drug screening model in the treatment of biliary tract malignant tumors
    Role: Project leader
  • 12/01/2015-11/30/2016
    Project of Shanghai Shenkang Hospital Development Center, ¥50,000, 2015SKMR-12
    Deepening and Expanding the Application of Disease Performance Analysis - Clinical Quality Sampling Analysis of Biliary and Pancreatic Diseases
    Role: Project leader
  • 01/01/2012-12/31/2014
    Project of Shanghai Health and Family Planning Commission, ¥400,000, XBR2011035
    The effect and mechanism of FXR on apoptosis and chemotherapy sensitivity of gallbladder cancer
    Role: Project leader
  • 01/01/2019-12/31/2021
    Shanghai Jiao Tong University Medical Engineering Cross project, ¥1,000,000, ZH2018ZDA09
    Development of a novel biodegradable magnesium zinc alloy biliary stent under endoscopy
    Role: Project leader
  1. [Jian Wang, Yonglong Zhang, Yanfeng Liu, Hui Wang, Yuchen Zhang] (2022), "Application of ceramide C24 as a biomarker in the diagnosis of gallbladder cancer", ZL201910059504.3
  2. [Jian Wang, Tao Chen] (2018), "A camera stand used in clinical medicine", ZL201720071283.8
  3. [Jian Wang, Tao Chen, Liming Xu, Wei Chen, Yixing Hu, Yu Chen, Yunhe Zhang, Yifei Qin] (2020), "A clamping type anti fog and thermal insulation device for laparoscopic lenses", ZL201620757124.9

Copyright © 2024, All Rights Reserved.