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WANG Hongmei
- Chief Physician, Graduate Supervisor
- Department: Neurology
- Research Area: Neurology
- Research Interests: Alzheimer’s disease and Cerebrovascular Disease
- Contact: dd-tt12345@163.com
- Visiting Scholar, Vanderbilt University Medical Center, 2015
- MD from Shanghai Jiao Tong University School of Medicine, 2010
- PhD from Shanghai Jiao Tong University, 2010
- Youth Council Member, Chinese Stroke Association
- Headache Group Member, China Society of Integrated Traditional Chinese and Western Medicine
- Yuan Y, Zhai Y, Chen J, Xu X, Wang H#. Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis. Biomolecules, 2021, doi: 10.3390/biom11070923.
- Yuan Y, Chen J, Zhang Y, Zhao F, Zhai Y, Xu X, Xue L, Zhao Y, Wang H#. Exploration of Risk Factors for Poor Prognosis of Non-Traumatic Non-Aneurysmal Subarachnoid Hemorrhage. Biomolecules, 2022, doi: 10.3390/biom12070948.
- Wang HM Zhang T, Ge XH, Chen JJ, Zhao YW, Fu JL. Parkin overexpression attenuates Aβ-induced mitochondrial dysfunction in HEK293 cells by restoring impaired mitophagy. Life Sci, 2020, doi: 10.1016/j.lfs.2020.117322.
- Yuan Y, Chen J, Ge X, Deng J, Xu X, Zhao Y, Wang H#. Activation of ERK-Drp1 signaling promotes hypoxia-induced Aβ accumulation by upregulating mitochondrial fission and BACE1 activity. FEBS Open Bio, 2021, doi: 10.1002/2211-5463.13273.
- Zhao Y, Zhang J, Zheng Y, Zhang Y, Zhang XJ, Wang H, Du Y, Guan J, Wang X, Fu J. NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway, J Neuroinflammation. 2021, doi: 10.1186/s12974-021-02250-8.
- Xue LX, Shu LY, Wang HM, Lu KL, Huang LG, Xiang JY, Geng Z, Zhao YW, Chen H. miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke. Neural Regen Res, 2023, doi: 10.4103/1673-5374.367957.
- Zhao Y, Zhang J, Zhang Y, Zhang Y, Zhang X, Zheng Y, Wang H, Wang X, Fu J. Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment. Int Immunopharmacol, 2022, doi: 10.1016/j.intimp.2022.108756.
- Wang HM, Zhang T, Huang JK, Xiang JY, Chen JJ, Fu JL, Zhao YW. Edaravone Attenuates the Proinflammatory Response in Amyloid-β-Treated Microglia by Inhibiting NLRP3 Inflammasome-Mediated IL-1β Secretion. Cell Physiol Biochem, 2017, doi: 10.1159/000481753.
- Wang HM, Zhang T, Li Q, Huang JK, Chen RF, Sun XJ. Inhibition of glycogen synthase kinase-3 beta by lithium chloride suppresses 6-hydroxydopamine-induced inflammatory response in primary cultured astrocytes. Neurochemistry International, 2013, doi: 10.1016/j.neuint.2013.07.003.
- Wang HM, Zhang T, Huang JK, Sun XJ. 3-N-Butylphthalide (NBP) Attenuates the Amyloid-beta-Induced Inflammatory Responses in Cultured Astrocytes via the Nuclear Factor-kappa B Signaling Pathway. Cell Physiol Biochem, 2013, doi: 10.1159/000350139.
- 01/01/2019-12/31/2022
National Natural Science Foundation of China, ¥560,000, 81870952
The mechanism of mitophagy in regulating Aβ-induced inflammation in microglia
Role: Project leader - 01/01/2012-12/31/2014
National Natural Science Foundation of China, ¥210,000, 81100953
The role of NF-κB pathway in Aβ-induced autophagy in neuronal cells.
Role: Project leader
