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WANG Niansong  

  • Chief Physician, Professor
  • Department: Nephrology
  • Research Area: Internal Medicine (Nephrology)
  • Research Interests: Pathogenesis and clinical study of diabetic nephropathy and acute kidney injury
  • Contact: wangniansong2012@163.com
Biography Positions Publications Research Projects Patents Other
  • MD from Shanghai Medical University, 1997
  • MBBS from Jiangxi Medical College, 1989
  • Director, Department of Nephrology, Shanghai Sixth People's Hospital
  • Chairman, Nephrology Society of Shanghai Medical Association
  • Chairman, Blood Purification Committee of China Medical Devices Industry Association
  • National Standing Committee Member, Nephrology Society of Chinese Medical Association 
  • National Standing Committee Member, Chinese Association of Integrative Medicine Nephrology
  • National Standing Committee Member, Nephrology Society of Chinese Medical Doctor Association
  • Vice president, Internal Medicine Chapter of Shanghai Medical Doctor Association
  • Vice president, Blood Purification Chapter of Shanghai Hospital Management Society
  1. Yang XH, Tu QM, Li L, Guo YP#, Wang NS#, Jin HM#. Triglyceride-lowering therapy for the prevention of cardiovascular events, stroke, and mortality in patients with diabetes: A meta-analysis of randomized controlled trials. Atherosclerosis. 2023 Jul 13:117187. doi: 10.1016/j.atherosclerosis.2023.117187. 
  2. Li Z, He L, Jiao J, Jia J, Xing H, Zhou T, Zhang Q, Chen Y, Jiang L, Wang N#, Fan Y#. Musculoskeletal Ultrasound Evaluates Renal Injury and Predicts Renal Outcome in Patients with Gout. Kidney Dis (Basel). 2022 Nov 21;9(2):94-103. doi: 10.1159/000528200
  3. Cheng D, Luo H, Ren S, Wang N#, Wu J#. The Effects of Fluid Hydration Status on Ultrasound Muscle Measurement in Hemodialysis Patients. J Ren Nutr. 2023 Jan;33(1):214-218. doi: 10.1053/j.jrn.2022.04.007. 
  4. Ling S, Chen T, Wang S, Zhang W, Zhou R, Xia X, Yao Z, Fan Y, Ning S, Liu J, Qin L, Tucker HO, Wang N#, Guo X#. Deacetylation of FOXP1 by HDAC7 potentiates self-renewal of mesenchymal stem cells. Stem Cell Res Ther. 2023 Jul 28;14(1):188. doi: 10.1186/s13287-023-03376-7. 
  5. Wang Y, Bai L, Wen J, Zhang F, Gu S, Wang F, Yin J#, Wang N#. Cardiac-specific renalase overexpression alleviates CKD-induced pathological cardiac remodeling in mice. Front Cardiovasc Med. 2022 Dec 15;9:1061146. doi: 10.3389/fcvm.2022.1061146
  6. Zhang W#, Li J, Yang P, Wang G, Yue Y, Zhong Y, Liu H, Gui D, Xu Y, Wang N#. Efficacy and Safety of Salvia miltiorrhiza for Treating Chronic Kidney Diseases: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2022 Jun 14;2022:2117433. doi: 10.1155/2022/2117433. 
  7. He L, Li Z, Zhang Q, Chen Y, Gao Y, Chen T, Wang N#, Jiang L#, Fan Y#. Evaluation of renal microperfusion in hyperuricemic nephropathy by contrast-enhanced ultrasound imaging. Dis Model Mech. 2022 Jul 1;15(7):dmm049382. doi: 10.1242/dmm.049382.
  8. Wang N, Xie Y, Jiang G#. Efficacy and safety of intravenous paricalcitol treatment in Chinese hemodialysis patients: a real-world database analysis. Ann Palliat Med. 2022 Jan;11(1):225-239. doi: 10.21037/apm-21-3966.
  9. Cheng D, Zhang Q, Wang Z, Li J, Jian G#, Wang N#. Association Between Sarcopenia and Its Components and Dependency in Activities of Daily Living in Patients on Hemodialysis. J Ren Nutr. 2021 Jul;31(4):397-402. doi: 10.1053/j.jrn.2020.08.016.
  10. He L, Zhang Q, Li Z, Shen L, Zhang J, Wang P, Wu S, Zhou T, Xu Q, Chen X, Fan X, Fan Y#, Wang N#. Incorporation of Urinary Neutrophil Gelatinase-Associated Lipocalin and Computed Tomography Quantification to Predict Acute Kidney Injury and In-Hospital Death in COVID-19 Patients. Kidney Dis (Basel). 2021 Mar;7(2):120-130. doi: 10.1159/000511403.
  11. Li X, Wen J, Dong Y, Zhang Q, Guan J, Liu F, Zhou T, Li Z, Fan Y#, Wang N#. Wnt5a promotes renal tubular inflammation in diabetic nephropathy by binding to CD146 through noncanonical Wnt signaling. Cell Death Dis. 2021 Jan 18;12(1):92. doi: 10.1038/s41419-020-03377-x.
  12. Lin W#, Wu X, Wen J, Fei Y, Wu J, Li X, Zhang Q, Dong Y, Xu T#, Fan Y, Wang N#. Nicotinamide retains Klotho expression and ameliorates rhabdomyolysis-induced acute kidney injury. Nutrition. 2021 Nov-Dec;91-92:111376. doi: 10.1016/j.nut.2021.111376.
  13. Cheng D, Fei Y, Saulnier PJ, Wang N#. Circulating TNF receptors and risk of renal disease progression, cardiovascular disease events and mortality in patients with diabetes: a systematic review and meta-analysis. Endocrine. 2020 Apr;68(1):32-43. doi: 10.1007/s12020-019-02153-y.
  14. Sheng X, Dong Y, Cheng D, Wang N#, Guo Y#. Efficacy and safety of Bailing capsules in the treatment of type 2 diabetic nephropathy: a meta-analysis. Ann Palliat Med. 2020 Nov;9(6):3885-3898. doi: 10.21037/apm-20-1799.
  15. Zhang Q, He L, Dong Y, Fei Y, Wen J, Li X, Guan J, Liu F, Zhou T, Li Z, Fan Y#, Wang N#. Sitagliptin ameliorates renal tubular injury in diabetic kidney disease via STAT3-dependent mitochondrial homeostasis through SDF-1α/CXCR4 pathway. FASEB J. 2020 Jun;34(6):7500-7519. doi: 10.1096/fj.201903038R.
  16. Wu X, Jian G, Tang Y, Cheng H, Wang N#, Wu J#. Asymptomatic hyperuricemia and incident congestive heart failure in elderly patients without comorbidities. Nutr Metab Cardiovasc Dis. 2020 Apr 12;30(4):666-673. doi: 10.1016/j.numecd.2019.12.008.
  17. Fan Y, Yi Z, D'Agati VD, Sun Z, Zhong F, Zhang W, Wen J, Zhou T, Li Z, He L, Zhang Q, Lee K, He JC#, Wang N#. Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression. Diabetes. 2019 Dec;68(12):2301-2314. doi: 10.2337/db19-0204.
  18. Sheng X, Yang J, Yu G, Fei Y, Bao H, Yin J, Huang W, Tian Z, Wang N#, Ronco C. Procalcitonin and N-Terminal Pro-B-Type Natriuretic Peptide for Prognosis in Septic Acute Kidney Injury Patients Receiving Renal Replacement Therapy. Blood Purif. 2019;48(3):262-271. doi: 10.1159/000501388.
  19. Zhai R, Jian G, Chen T, Xie L, Xue R, Gao C, Wang N#, Xu Y#, Gui D#. Astragalus membranaceus and Panax notoginseng, the Novel Renoprotective Compound, Synergistically Protect against Podocyte Injury in Streptozotocin-Induced Diabetic Rats. J Diabetes Res. 2019 Apr 16;2019:1602892. doi: 10.1155/2019/1602892. 
  20. Dong Y, Zhang Q, Wen J, Chen T, He L, Wang Y, Yin J, Wu R, Xue R, Li S, Fan Y#, Wang N#. Ischemic Duration and Frequency Determines AKI-to-CKD Progression Monitored by Dynamic Changes of Tubular Biomarkers in IRI Mice. Front Physiol. 2019 Feb 26;10:153. doi: 10.3389/fphys.2019.00153. 
  21. Wu R, Liu X, Yin J, Wu H, Cai X, Wang N#, Qian Y, Wang F#. IL-6 receptor blockade ameliorates diabetic nephropathy via inhibiting inflammasome in mice. Metabolism. 2018 Jun;83:18-24. doi: 10.1016/j.metabol.2018.01.002.
  22. Li J, Sheng X, Cheng D, Wang F, Jian G#, Li Y, Xu T, Wang X, Fan Y, Wang N#. Is the mean platelet volume a predictive marker of a high in-hospital mortality of acute cardiorenal syndrome patients receiving continuous renal replacement therapy? Medicine (Baltimore). 2018 Jun;97(25):e11180. doi: 10.1097/MD.0000000000011180.
  23. Li J, Li Y, Sheng X, Wang F, Cheng D, Jian G, Li Y, Feng L, Wang N#. Combination of Mean Platelet Volume/Platelet Count Ratio and the APACHE II Score Better Predicts the Short-Term Outcome in Patients with Acute Kidney Injury Receiving Continuous Renal Replacement Therapy. Kidney Blood Press Res. 2018;43(2):479-489. doi: 10.1159/000488694.
  24. Fan Y, Fei Y, Zheng L#, Wang J, Xiao W, Wen J, Xu Y, Wang Y, He L, Guan J, Wei J, He JC#, Wang N#. Expression of Endothelial Cell Injury Marker Cd146 Correlates with Disease Severity and Predicts the Renal Outcomes in Patients with Diabetic Nephropathy. Cell Physiol Biochem. 2018;48(1):63-74. doi: 10.1159/000491663. 
  25. Tian S, Jiang Z, Liu Y, Niu X, Hu B, Guo S, Wang N#, Wang Y#. Human Urine-derived Stem Cells Contribute to The Repair of Ischemic Acute Kidney Injury in Rats. Mol Med Rep. 2017 Oct;16(4):5541-5548. doi: 10.3892/mmr.2017.7240. 
  26. Wu R, Liu X, Yin J, Wu H, Cai X, Wang N#, Qian Y, Wang F#. IL-6 Receptor Blockade Ameliorates Diabetic Nephropathy via Inhibiting Inflammasome in Mice. Metabolism. 2018 Jun;83:18-24. doi: 10.1016/j.metabol.2018.01.002. 
  27. Xue R, Gui D, Zheng L, Zhai R, Wang F#, Wang N#. Mechanistic Insight and Management of Diabetic Nephropathy: Recent Progress and Future Perspective. J Diabetes Res. 2017;2017:1839809. doi: 10.1155/2017/1839809.
  28. He L, Fan Y#, Xiao W, Chen T, Wen J, Dong Y, Wang Y, Li S, Xue R, Zheng L, He JC#, Wang N#. Febuxostat Attenuates ER Stress Mediated Kidney Injury in a Rat Model of Hyperuricemic Nephropathy. Oncotarget. 2017 Nov 30;8(67):111295-111308. doi: 10.18632/oncotarget.22784.
  29. Wu J, Lei G, Wang X, Tang Y, Cheng H, Jian G, Wu X#, Wang N#. Asymptomatic Hyperuricemia and Coronary Artery Disease in Elderly Patients without Comorbidities. Oncotarget. 2017 Sep 19;8(46):80688-80699. doi: 10.18632/oncotarget.21079.
  30. Zeng C, Cheng D, Sheng X#, Jian G, Fan Y, Chen Y, Li J, Bao H, Wang N#. Increased Serum Uric Acid Level Is a Risk Factor for Left Ventricular Hypertrophy but Not Independent of eGFR in Patients with Type 2 Diabetic Kidney Disease. J Diabetes Res. 2017;2017:5016093. doi: 10.1155/2017/5016093.
  31. Fan Y, Xiao W, Lee K, Salem F, Wen J, He L, Zhang J, Fei Y, Cheng D, Bao H, Liu Y, Lin F, Jiang G, Guo Z, Wang N#, He JC#. Inhibition of Reticulon-1A-Mediated Endoplasmic Reticulum Stress in Early AKI Attenuates Renal Fibrosis Development. J Am Soc Nephrol. 2017 Jul;28(7):2007-2021. doi: 10.1681/ASN.2016091001.
  32. Fan Y, Zhang J, Xiao W, Lee K, Li Z, Wen J, He L, Gui D, Xue R, Jian G, Sheng X, He JC#, Wang N#. Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy. Sci Rep. 2017 Mar 23;7(1):323. doi: 10.1038/s41598-017-00305-6. 
  33. Wang F#, Yin J, Lu Z, Zhang G, Li J, Xing T, Zhuang S#, Wang N#. Limb Ischemic Preconditioning Protects against Contrast-induced Nephropathy via Renalase. EBioMedicine. 2016 Jul;9:356-365. doi: 10.1016/j.ebiom.2016.05.017. 
  34. Lu Z，Zhang G, Xie Y, Li J, Wang N#, Yan C#, Wang F#. Serum Levels of RBP4 Might Not Be Determined by Diabetes Mellitus but by Kidney Function and Renal Replacement Therapy. J. Shanghai Jiaotong Univ. (Sci.), 2016, 21(6): 757-762. doi: 10.1007/s12204-016-1791-3.
  35. Wang X, Shen E, Wang Y, Li J, Cheng D, Chen Y, Gui D#, Wang N#. Cross Talk Between MiR-214 and PTEN Attenuates Glomerular Hypertrophy Under Diabetic Conditions. Sci Rep. 2016 Aug 23;6:31506. doi: 10.1038/srep31506.
  36. Zhang J, Fan Y, Zeng C, He L, Wang N#. Tauroursodeoxycholic Acid Attenuates Renal Tubular Injury in a Mouse Model of Type 2 Diabetes. Nutrients. 2016 Sep 22;8(10):589. doi: 10.3390/nu8100589. 
  37. Wang F#, Peng C, Zhang G, Zhao Q, Xuan C, Wei M, Wang N#. Delayed Kidney Injury Following Coronary Angiography. Exp Ther Med. 2016 Jul;12(1):530-534. doi: 10.3892/etm.2016.3315. 
  38. Huang B, Cheng Y, Usa K, Liu Y, Baker MA, Mattson DL, He Y, Wang N#, Liang M#. Renal Tumor Necrosis Factor α Contributes to Hypertension in Dahl Salt-Sensitive Rats. Sci Rep. 2016 Feb 26;6:21960. doi: 10.1038/srep21960.
  39. Yin J, Lu Z, Wang F#, Jiang Z, Lu L, Miao N, Wang N#. Renalase Attenuates Hypertension, Renal Injury and Cardiac Remodelling in Rats with Subtotal Nephrectomy. J Cell Mol Med. 2016 Jun;20(6):1106-17. doi: 10.1111/jcmm.12813.
  40. Jiang Z, Liu Y, Niu X, Yin J, Hu B, Guo S, Fan Y, Wang Y#, Wang N#. Exosomes Secreted by Human Urine-derived Stem Cells Could Prevent Kidney Complications from Type I Diabetes in Rats. Stem Cell Res Ther. 2016 Feb 6;7:24. doi: 10.1186/s13287-016-0287-2.
  41. Guo Y, Jiang Q, Gui D#, Wang N#. Chinese Herbal Formulas Si-Wu-Tang and Er-Miao-San Synergistically Ameliorated Hyperuricemia and Renal Impairment in Rats Induced by Adenine and Potassium Oxonate. Cell Physiol Biochem. 2015;37(4):1491-502. doi: 10.1159/000438517. 
  • 01/2023-12/2026
    National Natural Science Foundation of China (General Program),  ¥520,000, 82270761
    Study on the Mechanism of Wnt5a-FOXP1-Notch2 Axis Mediated Tubular Injury in Diabetic Nephropathy
    Role: Project leader
  • 05/2022-12/2022
    Shanghai Sixth People's Hospital Emergency Special Project for Combating COVID-19,  ¥200,000
    Efficacy of Cytokine Adsorption Combined with Continuous Blood Purification Treatment in Hemodialysis Patients with Severe COVID-19: A Single-Center, Open, Parallel-Controlled Clinical Trial
    Role: Project leader
  • 09/2019-09/2022
    Shanghai Municipal Health Commission Project,  ¥300,000, 2019SY018
    Promotion and Application of Peritoneal Dialysis Follow-up Management Model in Primary Hospitals
    Role: Project leader
  • 01/2019-01/2023
    National Natural Science Foundation of China (General Program),  ¥570,000, 81870504
    Study on the Molecular Mechanism of Renalase in Inhibiting Chronic Kidney Disease-Induced Cardiac Remodeling through the PMCA4b/calcineurin/NFAT Signaling Pathway
    Role: Project leader
  • 12/2018-12/2022
    Shanghai Municipal Leading Talent Program,  ¥1600,000, 2018-12
    New Mechanisms and Prevention of Diabetic Nephropathy
    Role: Project leader
  • 01/2017-02/2021
    National Natural Science Foundation of China (General Program),  ¥580,000, 81670657
    Study on the Role and Mechanism of CD146 in the Wnt5a/JNK Signaling Pathway and Its Effects on Podocyte Injury and Epithelial-Mesenchymal Transition in Diabetic Nephropathy
    Role: Project leader
  • 12/2016-12/2018
    Key Projects of Xuhui District, Shanghai,  ¥200,000, SHXH201648
    Promotion and Application of Peritoneal Dialysis Follow-up in Primary Hospitals
    Role: Project leader
  • 12/2016-12/2018
    Shanghai Municipal General Hospital Traditional Chinese and Western Medicine Integration Special Project,  ¥100,000, ZHYY-ZXYJHZX-201608
    A Randomized Controlled Clinical Study on the Prevention and Treatment of Early Diabetic Nephropathy Podocyte Injury with Qi-Boosting and Blood-Activating Formula
    Role: Project leader
  • 01/2016-12/2018
    Shanghai Jiao Tong University Translational Medicine Project,  ¥100,000, 152H2011
    Clinical Application Study of Early Diagnostic Biomarkers for Diabetic Nephropathy Based on Differential Expression Profiles of microRNAs
    Role: Project leader
  • 01/2013-12/2016
    National Natural Science Foundation of China (General Program),  ¥700,000, 81270824
    The Predictive Value of Renalase for Cardiovascular Events in Patients with Chronic Kidney Disease and the Experimental Study on Renalase Replacement Therapy for Chronic Renal Failure
    Role: Project leader
  • 07/2011-06/2014
    Shanghai International Science and Technology Cooperation Fund Project,  ¥250,000, 11410708500
    Study on the Mechanism of MicroRNA Targeting GSK3beta Involved in Diabetic Nephropathy Mesangial Cell Hypertrophy
    Role: Project leader
  • 07/2011-06/2014
    Shanghai Science and Technology Commission Project. ¥100,000, 11DZ1973103
    A Multicenter, Large Sample, Prospective Study on the Treatment of Chronic Renal Failure of Spleen Deficiency and Damp-Heat Type with Spleen-Strengthening and Detoxifying Method
    Role: Sub-Project leader
  • 07/2011-06/2013
    Shanghai Municipal Education Commission Project. ¥100,000, 11DZ1921904
    Clinical Efficacy Evaluation of High-Volume Hemodialysis Combined with Conventional Hemodialysis and Hemodiafiltration
    Role: Sub-Project leader
  • 01/2011-06/2013
    Shanghai Science and Technology Commission Project. ¥100,000, 114119a6100
    Screening of High-Affinity Monoclonal Antibodies Against Renalase and Establishment of Detection Techniques
    Role: Project leader
  • 01/2011-12/2013
    Shanghai Science and Technology Commission Major Basic Research Project. ¥100,000, 11DJ1400101
    Mechanisms and Intervention Strategies for Gout and Hyperuricemia
    Role: Sub-Project leader
  1. [Feng Wang, Niansong Wang] (2008), “Low-Protein Foods and Their Preparation Methods”, CN200810201611.7
  • 2016 - Third Prize of Shanghai Traditional Chinese Medicine Science and Technology Award,  "Mechanisms of Diabetic Nephropathy and Integrated Traditional Chinese and Western Medicine Prevention and Treatment"
  • 2016 - Third Prize of Shanghai Integrated Traditional Chinese and Western Medicine Science and Technology Award, "New Mechanisms of Diabetic Nephropathy and Integrated Traditional Chinese and Western Medicine Prevention and Treatment"
  • 2016 - Second Prize of Military Science and Technology Progress Award, "Prevention and Treatment of Hepatitis B Virus Infection and Glomerular Diseases"
  • 2017 - First Prize of China Integrated Traditional Chinese and Western Medicine Science and Technology Award, "New Mechanisms of Diabetic Nephropathy and New Strategies for Integrated Traditional Chinese and Western Medicine Prevention and Treatment"
  • 2019 - Second Prize of Shanghai Science and Technology Progress Award, "New Mechanisms of Diabetic Nephropathy and New Strategies for Clinical Diagnosis and Treatment"

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