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TIAN Haijun  

  • Graduate Supervisor, Researcher, Associate Chief Physician
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Spine Surgery
  • Contact: tianspine@163.com
Biography Positions Publications Patents Other
  • Assistant Researcher, UCLA Spine Center, 2013
  • MD & PHD from Second Military Medical University, 2011
  • Master's Degree in Medicine from Second Military Medical University, 2008
  • Bachelor's Degree in Medicine from Second Military Medical University, 2006
  • Associate Professor, Department of Orthopedics, Shanghai Sixth People's Hospital
  • Member of AO Spine International
  • Member of the North American Society of Spinal Surgery (NASS)
  • Member of the Chinese Spine Surgery Committee of the International Association of Orthopaedic and Trauma Surgery (SICOT)
  • Member of the Spinal Cord Injury Professional Committee of China Association for the Promotion of International Exchanges in Healthcare
  • Youth member of Bone and Injury Rehabilitation Committee, Chinese Rehabilitation Medical Association
  • Member of the science Popularization Working Group of the spinal Cord Special Committee of the Chinese Rehabilitation Medical Association
  • Member of the Cervical spine Group of Shanghai Rehabilitation Medical Association
  1. Zhang K, Wang X, Zeng LT, Yang X, Cheng XF, Tian H, Chen C, Sun XJ, Zhao CQ,Ma H, Zhao J. Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in ligamentum flavum hypertrophy. FASEB J. 2023 May;37(5):e22877.
  2. Chen H, Li C, Zhou T, Li X, Duarte MEL, Daubs MD, Buser Z, Brochmann EJ, Wang JC, Murray SS, Jiao L, Tian H. Secreted phosphoprotein 24 kD (Spp24) inhibits the growth of human osteosarcoma through the BMP-2/Smad signaling pathway. J Orthop Res. 2023 Aug;41(8):1803-1814. 
  3. Jin Q, Liu Y, Zhang Z, Wen X, Chen Z, Tian H, Kang Z, Wu X, Xu H. MYC promotes fibroblast osteogenesis by regulating ALP and BMP2 to participate in ectopic ossification of ankylosing spondylitis. Arthritis Res Ther. 2023 Feb 21;25(1):28. 
  4. Yang X, Li B, Tian H, Cheng X, Zhou T, Zhao J. Curcumenol Mitigates the Inflammation and Ameliorates the Catabolism Status of the Intervertebral Discs In Vivo and In Vitro via Inhibiting the TNFα/NFκB Pathway. Front Pharmacol. 2022 Jun 20;13:905966.
  5. Cheng X, Zhang K, Sun X, Tian H, Zhao C, Zhao J. Unilateral versus bilateral pedicle screw fixation with transforaminal lumbar interbody fusion for treatment of lumbar foraminal stenosis. Spine J. 2022 Oct;22(10):1687-1693. 
  6. Zhou T, Yang X, Chen Z, Yang Y, Wang X, Cao X, Chen C, Han C, Tian H, Qin A, Fu J, Zhao J. Prussian Blue Nanoparticles Stabilize SOD1 from Ubiquitination- Proteasome Degradation to Rescue Intervertebral Disc Degeneration. Adv Sci (Weinh). 2022 Apr;9(10):e2105466. 
  7. Sun X, Qiao H, Cheng X, Tian H, Shen K, Jin W, Liu X, Wang Q, Miao Y, Xu Y, Zhao C, Zhao J. Case Report: Identifying Andersson-Like Lesions in Diffuse Idiopathic Skeletal Hyperostosis. Front Endocrinol (Lausanne). 2021 Nov 30;12:766209.
  8. Chen H, Fu Y, Feng K, Zhou Y, Wang X, Huang H, Chen Y, Wang W, Xu Y, Tian H, Mao Y, Wang J, Zhang Z. Polydopamine-coated UiO-66 nanoparticles loaded with perfluorotributylamine/tirapazamine for hypoxia-activated osteosarcoma therapy. J Nanobiotechnology. 2021 Sep 30;19(1):298.
  9. Yang X, Zhou Y, Chen Z, Chen C, Han C, Li X, Tian H, Cheng X, Zhang K, Zhou T, Zhao J. Curcumenol mitigates chondrocyte inflammation by inhibiting the NF‑κB and MAPK pathways, and ameliorates DMM‑induced OA in mice. Int J Mol Med. 2021 Oct;48(4):192. 
  10. Wu A, Dong W, Zeng X, Xu X, Xu T, Zhang K, Tian H, Zhao J, Wang X, Zhou M. Neck pain is the leading cause of disability burden in China: Findings from the Global Burden of Disease Study 2017. Ann Transl Med. 2021 May;9(9):777. 
  11. Du L, Gao Y, Zhao C, Zhou T, Tian H, Zhang K, Zhao J. Laminoplasty with selective fusion at unstable segment versus laminectomy with fusion for multilevel cervical myelopathy: a case-control study. BMC Musculoskelet Disord. 2021 May 7;22(1):426.
  12. Kodama J, Chen H, Zhou T, Kushioka J, Okada R, Tsukazaki H, Tateiwa D, Nakagawa S, Ukon Y, Bal Z, Tian H, Zhao J, Kaito T. Antibacterial efficacy of quaternized chitosan coating on 3D printed titanium cage in rat intervertebral disc space. Spine J. 2021 Jul;21(7):1217-1228.
  13. Yang X, Chen Z, Chen C, Han C, Zhou Y, Li X, Tian H, Cheng X, Zhang K, Qin A, Zhou T, Zhao J. Bleomycin induces fibrotic transformation of bone marrow stromal cells to treat height loss of intervertebral disc through the TGFβR1/Smad2/3 pathway. Stem Cell Res Ther. 2021 Jan 7;12(1):34. 
  14. Wang H, Zhou WX, Huang JF, Zheng XQ, Tian H, Wang B, Fu WL, Wu AM. Endocrine Therapy for the Functional Recovery of Spinal Cord Injury. Front Neurosci. 2020 Dec 17;14:590570. 
  15. Wang H, Zheng X, Zhang Y, Huang J, Zhou W, Li X, Tian H, Wang B, Xing D, Fu W, Chen T, Wang X, Zhang X, Wu A. The endocrine role of bone: Novel functions of bone-derived cytokines. Biochem Pharmacol. 2021 Jan;183:114308. 
  16. Huang JF, Meng Z, Zheng XQ, Qin Z, Sun XL, Zhang K, Tian H, Wang XB, Gao Z, Li YM, Wu AM. Real-World Evidence in Prescription Medication Use Among U.S. Adults with Neck Pain. Pain Ther. 2020 Dec;9(2):637-655. 
  17. Chen C, Zhou T, Sun X, Han C, Zhang K, Zhao C, Li X, Tian H, Yang X, Zhou Y, Chen Z, Qin A, Zhao J. Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs. Bone Res. 2020 Feb 13;8:7. 
  18. Li X, Wu A, Han C, Chen C, Zhou T, Zhang K, Yang X, Chen Z, Qin A, Tian H, Zhao J. Bone marrow-derived mesenchymal stem cells in three-dimensional co- culture attenuate degeneration of nucleus pulposus cells. Aging (Albany NY). 2019 Oct 30;11(20):9167-9187. 
  19. Tian H, Zhou T, Chen H, Li C, Jiang Z, Lao L, Kahn SA, Duarte MEL, Zhao J, Daubs MD, Buser Z, Brochmann EJ, Wang JC, Murray SS. Bone morphogenetic protein-2 promotes osteosarcoma growth by promoting epithelial-mesenchymal transition (EMT) through the Wnt/β-catenin signaling pathway. J Orthop Res. 2019 Jul;37(7):1638-1648. doi: 10.1002/jor.24244. Epub 2019 Mar 28. PMID: 30737824.  
  20. Wu AM, Li XL, Tian H, Zhang K, Zhao CQ, Sheng SR, Lin Y, Ni WF, Wang XY, Zhao J. Optimal medial transforaminal lumbar interbody fusion approach with five extensive options: A simulated study on three-dimensional digital reconstructed images. J Orthop Translat. 2018 Aug 6;15:1-8. 
  21. Tian H, Wu A, Guo M, Zhang K, Chen C, Li X, Cheng X, Zhou T, Murray SS, Sun X, Zhao J. Adequate Restoration of Disc Height and Segmental Lordosis by Lumbar Interbody Fusion Decreases Adjacent Segment Degeneration. World Neurosurg. 2018 Oct;118:e856-e864. 
  22. Gu Q, Tian H, Zhang K, Chen D, Chen D, Wang X, Zhao J. Wnt5a/FZD4 Mediates the Mechanical Stretch-Induced Osteogenic Differentiation of Bone Mesenchymal Stem Cells. Cell Physiol Biochem. 2018;48(1):215-226. 
  23. Wu AM, Zhang K, Li XL, Cheng XF, Zhou TJ, Du L, Chen C, Tian H, Sun XJ, Zhao CQ, Li YM, Zhao J. The compression of L5 nerve root, single or double sites?-radiographic graded signs, intra-operative detect technique and clinical outcomes. Quant Imaging Med Surg. 2018 May;8(4):383-390.
  24. Zhang F, Zhang K, Tian H, Wu AM, Cheng XF, Zhou TJ, Zhao J. Correlation between lumbar intervertebral disc height and lumbar spine sagittal alignment among asymptomatic Asian young adults. J Orthop Surg Res. 2018 Feb 12;13(1):34.
  25. Lao L, Shen J, Tian H, Zhong G, Murray SS, Wang JC. Secreted phosphoprotein 24kD (Spp24) inhibits growth of hepatocellular carcinoma in vivo. Environ Toxicol Pharmacol. 2017 Apr;51:51-55. 
  26. Tian H, Zhao J, Brochmann EJ, Wang JC, Murray SS. Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy. Cytokine Growth Factor Rev. 2017 Apr;34:73-91. 
  27. Lao L, Shen J, Tian H, Yao Q, Li Y, Qian L, Murray SS, Wang JC. Secreted Phosphoprotein 24 kD Inhibits Growth of Human Prostate Cancer Cells Stimulated by BMP-2. Anticancer Res. 2016 Nov;36(11):5773-5780. 
  28. Tian H, Du J, Wen J, Liu Y, Montgomery SR, Scott TP, Aghdasi B, Xiong C, Suzuki A, Hayashi T, Ruangchainikom M, Phan K, Weintraub G, Raed A, Murray SS, Daubs MD, Yang X, Yuan XB, Wang JC, Lu Y. Growth-Factor Nanocapsules That Enable Tunable Controlled Release for Bone Regeneration. ACS Nano. 2016 Aug 23;10(8):7362-9. 
  29. Hayashi T, Lord EL, Suzuki A, Takahashi S, Scott TP, Phan K, Tian H, Daubs MD, Shiba K, Wang JC. A comparison of commercially available demineralized bone matrices with and without human mesenchymal stem cells in a rodent spinal fusion model. J Neurosurg Spine. 2016 Jul;25(1):133-7. 
  30. Zeng C, Xiong J, Wang JC, Inoue H, Tan Y, Tian H, Aghdasi B. The Evaluation and Observation of "Hidden" Hypertrophy of Cervical Ligamentum Flavum, Cervical Canal, and Related Factors Using Kinetic Magnetic Resonance Imaging. Global Spine J. 2016 Mar;6(2):155-63. 
  31. Li CS, Tian H, Zou M, Zhao KW, Li Y, Lao L, Brochmann EJ, Duarte ME, Daubs MD, Zhou YH, Murray SS, Wang JC. Secreted phosphoprotein 24 kD (Spp24) inhibits growth of human pancreatic cancer cells caused by BMP-2. Biochem Biophys Res Commun. 2015 Oct 16;466(2):167-72.
  32. Scott TP, Phan KH, Tian H, Suzuki A, Montgomery SR, Johnson JS, Atti E, Tetratis S, Pereira RC, Wang JC, Daubs MD, Stappenbeck F, Parhami F. Comparison of a novel oxysterol molecule and rhBMP2 fusion rates in a rabbit posterolateral lumbar spine model. Spine J. 2015 Apr 1;15(4):733-42. 
  33. Tian H, Li CS, Zhao KW, Wang JC, Duarte ME, David CL, Phan K, Atti E, Brochmann EJ, Murray SS. A carboxy terminal BMP/TGF-β binding site in secreted phosphoprotein 24 kD independently affects BMP-2 activity. J Cell Biochem. 2015 Apr;116(4):667-76. 
  34. Murray SS, Wang JC, Duarte ME, Zhao KW, Tian H, Francis T, Brochmann Murray EJ. The bone matrix protein secreted phosphoprotein 24 kD (Spp24): bone metabolism regulator and starting material for biotherapeutic materials. Histol Histopathol. 2015 May;30(5):531-7. 
  35. Tian H, Li CS, Scott TP, Montgomery SR, Phan K, Lao L, Zhang W, Li Y, Hayashi T, Takahashi S, Alobaidaan R, Ruangchainikom M, Zhao KW, Brochmann EJ, Murray SS, Wang JC, Daubs MD. Secreted phosphoprotein 24 kD inhibits nerve root inflammation induced by bone morphogenetic protein-2. Spine J. 2015 Feb 1;15(2):314-21. 
  36. Inoue H, Montgomery SR, Aghdasi B, Kaner T, Tan Y, Tian H, Terrell R, Wang JC, Daubs MD. The effect of bone morphogenetic protein-2 injection at different time points on intervertebral disk degeneration in a rat tail model. J Spinal Disord Tech. 2015 Feb;28(1):E35-44. 
  37. Ruangchainikom M, Daubs MD, Suzuki A, Hayashi T, Weintraub G, Lee CJ, Inoue H, Tian H, Aghdasi B, Scott TP, Phan KH, Chotivichit A, Wang JC. Effect of cervical kyphotic deformity type on the motion characteristics and dynamic spinal cord compression. Spine (Phila Pa 1976). 2014 May 20;39(12):932-8. 
  38. Montgomery SR, Nargizyan T, Meliton V, Nachtergaele S, Rohatgi R, Stappenbeck F, Jung ME, Johnson JS, Aghdasi B, Tian H, Weintraub G, Inoue H, Atti E, Tetradis S, Pereira RC, Hokugo A, Alobaidaan R, Tan Y, Hahn TJ, Wang JC, Parhami F. A novel osteogenic oxysterol compound for therapeutic development to promote bone growth: activation of hedgehog signaling and osteogenesis through smoothened binding. J Bone Miner Res. 2014 Aug;29(8):1872-85.
  39. Kaito T, Johnson J, Ellerman J, Tian H, Aydogan M, Chatsrinopkun M, Ngo S, Choi C, Wang JC. Synergistic effect of bone morphogenetic proteins 2 and 7 by ex vivo gene therapy in a rat spinal fusion model. J Bone Joint Surg Am. 2013 Sep 4;95(17):1612-9. 
  40. Tian H, Bi X, Li CS, Zhao KW, Brochmann EJ, Montgomery SR, Aghdasi B, Chen D, Daubs MD, Wang JC, Murray SS. Secreted phosphoprotein 24 kD (Spp24) and Spp14 affect TGF-β induced bone formation differently. PLoS One. 2013 Aug 26;8(8):e72645. 
  41. Xiong C, Daubs MD, Montgomery SR, Aghdasi B, Inoue H, Tian H, Suzuki A, Tan Y, Hayashi T, Ruangchainikom M, Chai T, Corey M, Wang JC. BMP-2 adverse reactions treated with human dose equivalent dexamethasone in a rodent model of soft-tissue inflammation. Spine (Phila Pa 1976). 2013 Sep 1;38(19):1640-7. 
  42. Tan Y, Montgomery SR, Aghdasi BG, Inoue H, Kaner T, Tian H, Terrell R, Zhang X, Wang JC, Daubs MD. The effect of corticosteroid administration on soft-tissue inflammation associated with rhBMP-2 use in a rodent model of inflammation. Spine (Phila Pa 1976). 2013 May 1;38(10):806-13. 
  43. Inoue H, Montgomery S, Aghdasi B, Tan Y, Tian H, Jian X, Terrell R, Singh V, Wang JC. Analysis of Relationship between Paraspinal Muscle Fatty Degeneration and Cervical Spine Motion Using Kinetic Magnetic Resonance Imaging. Global Spine J. 2012 Mar;2(1):33-8. 
  44. Tian H, Yuan W, Johnson JS, Chen H, Chen D. Pharyngoesophageal diverticulum: a delayed complication of anterior cervical spine surgery. Eur Spine J. 2011 Jul;20 Suppl 2(Suppl 2):S211-6. 
  1. [Zhao Jie;Wu Aimin;Zhang Kai;Tian Haijun;Cheng Xiaofei;Zhou Tangjun;Li Xunlin;Han Chen;Chen Chen;Chen Zhiqian;Zhou Yifan;Yang Xiao] (2018), "Rear-entry lumbar cage unit",  PCT/CN109172055A
  2. [Zhao Jie;Tian Haijun;Sun Xiaojiang;Cheng Xiaofei;Zhang Kai] (2018), "The invention relates to a spinal titanium mesh bone fusion apparatus and a manufacturing method thereof”PCT/CN111329628A
  3. [Tian Haijun;Guo Mingke;Be unrestrained;Zhang Hongguang;Zhu Jixing;Gao Jianhong;Wang Xuemin;Meng Xiantao]  (2015) "A kind of automatic extension of retractor during operation of flexor tendon stricture tenosynovitis" PCT/CN204542250U

Book Chapters

  • Modern Spinal Surgery, World Book Publishing Company, 2017
  • Ossification of Spinal Ligaments, Shanghai Science and Technology Press, 2014
  • Spinal Re-surgery Design and Operation Skills, Shanghai Science and Technology Press, 2014
  • AO Spine Manual, Shandong Science and Technology Press, 2010
  • Intractable Orthopedic Disease, Scientific and Technical Academic Press, 2009
  • Diagnosis and Treatment of Lumbar Spine Injuries, Scientific and Technical Academic Press, 2008
  • Revision Surgery of Lumbar Spine. In: Complicated Orthopedics. Shanghai. 2007.
  • Diagnosis and Treatment for Lumbar Diseases and Traumas. Shanghai. 2006

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