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SHEN Longxiang  

  • Chief Physician, Graduate Supervisor
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Repair of Bone and Soft Tissue Defects
  • Contact: shenlongxiang@sjtu.edu.cn
Biography Positions Publications Research Projects Patents
  • Chief Physician, Shanghai Sixth People's Hospital, 2024
  • Deputy Chief Physician, Shanghai Sixth People's Hospital, 2021
  • Attending Surgeon, Shanghai Sixth People's Hospital, 2014
  • Surgeon, Shanghai Sixth People's Hospital, 2012
  • Postdoc, Shanghai Jiao Tong University, 2012
  • PhD from Fudan University, 2009
  • MM from Zhejiang Chinese Medical University, 2006
  • Associate Group Leader, Orthopedics and Arthrology Professional Group of the Chinese Volunteer Association's Expert Volunteer Committee, Integrated Traditional Chinese and Western Medicine
  • Commissioner, Arthrology Group of the Orthopedics and Traumatology , Chinese Association for the Promotion of Traditional Chinese Medicine Research
  • Commissioner, Perthes Disease Group of the Pediatric Orthopedic Specialist Committee, Orthopedic Physicians Branch of the Chinese Medical Association
  • Expert, Construction of the Health Talent Evaluation Question Bank, National Health Commission Talent Exchange Service Center
  • Commissioner, Regeneration and Rehabilitation Committee, Chinese Rehabilitation Medicine Association
  • Youth Commissioner, Orthopedics and Traumatology Professional Committee, Shanghai Association of Traditional Chinese and Western Medicine
  • Editorial Board Member, Chinese Journal of Experimental Surgery
  • Youth Editorial Board Member, Chinese Bone Trauma
  • English Editor, International Journal of Orthopedics
  • Reviewer, Chinese Medical Journal
  1. Geng B#, Hu J, He X, Zhang Z, Cai J, Pan D#, Shen L#, Single Atom Catalysts Remodel Tumor Microenvironment for Augmented Sonodynamic Immunotherapy. Adv. Mater. 2024, 2313670.
  2. Zhou L, Guo S, Dong Z, Liu P, Shi W#, Shen L#, Yin J#, Electron irradiation of zein protein-loaded nano CaO2/CD for enhancing infectious diabetic wounds with adaptive hydrophobicity-to-hydrophilicity, Materials Today Advances, 2024, 100458
  3. Hu J, He X, Cai J, Zhang Z, Bai X, Zhang S, Geng B#, Pan D#, Shen L#, Biodegradable CoSnO3 nanozymes modulate pH-responsive graphene quantum dot release for synergistic chemo-sonodynamic-nanocatalytic cancer therapy, Chemical Engineering Journal, 2024, 148561
  4. Su Y, Hu J, Wang Y, Li Y, Xiao L, He X, Zhang Z, Cai J, Pan D, Chen Y, Geng B#, Li P#, Shen L#. N-Heterocycle Modified Graphene Quantum Dots as Topoisomerase Targeted Nanoantibiotics for Combating Microbial Infections. Adv Healthc Mater. 2023 Nov 27:e2302659. 
  5. Shen L, Ye K, An Z#. Comparison of augmentation effects of medial buttress plate versus trochanteric lag screw in the cannulated screw fixation of Pauwels type III femoral neck fractures: A retrospective clinical study. Acta Orthop Traumatol Turc. 2023; 23066. 
  6. Ye K, Shen L*, Tang J, An Z#, Morphological analysis of the posterior elements of associated both-column acetabular fractures. Acta Radiol. 2023; 64(4):1556-1565. 
  7. Zhang S, Zhang L, Hu J, He X, Geng B#, Pan D#, Shen L#, Trienzyme-like Co3O4@TiO2-x nanozymes for heterojunction-enhanced nanocatalytic-sonodynamic tumor therapy. Chemical Engineering Journal. 2023;458:141485. 
  8. Jiang C, Lu Y, Zhu R, Zong Y, Huang Y, Wang D, Da Z, Yu B, Shen L#, Cao Q#. Pyruvate dehydrogenase beta subunit (Pdhb) promotes peripheral axon regeneration by regulating energy supply and gene expression. Experimental Neurology. 2023:114368. 
  9. Dong Z, Yin J, Zhou X, Li S, Fu Z, Liu P, Shen L#, Shi W#. Natural and biocompatible dressing unit based on tea carbon dots modified core-shell electrospun fiber for diabetic wound disinfection and healing. Colloids Surf B Biointerfaces. 2023;226:113325. 
  10. Li S, Dong Z, Wang Q, Zhou X, Shen L#, Li H#, Shi W#. Antibacterial Z-scheme ZnIn(2)S(4)/Ag(2)MoO(4) composite photocatalytic nanofibers with enhanced photocatalytic performance under visible light. Chemosphere. 2022;308(Pt 3):136386.  
  11. Geng B, Zhang S, Yang X, Shi W, Li P, Pan D#, Shen L#. Cu2-xO@TiO2-y Z-scheme heterojunctions for sonodynamic-chemodynamic combined tumor eradication. Chemical Engineering Journal. 2022;435:134777. 
  12. Geng B, Xu S, Li P, Li X, Fang F, Pan D#, Shen L#. Platinum Crosslinked Carbon Dot@TiO2−x p-n Junctions for Relapse-Free Sonodynamic Tumor Eradication via High-Yield ROS and GSH Depletion. Small. 2022;18(6):2103528. 
  13. Geng B, Hu J, Li Y, Feng S, Pan D#, Feng L#, Shen L#. Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy. Nat Commun. 2022;13(1):5735. 
  14. Geng B, Hu J, Li P, Pan D#, Shen L#. DNA binding graphene quantum dots inhibit dual topoisomerases for cancer chemotherapy. Carbon. 2022;187:365-74. 
  15. Wang Q, Ji S, Xu Q, Shen L#, Shi W#. Preparation of PEO-based Cu2O/Bi2O2CO3 electrospun fibrous membrane toward enhanced photocatalytic degradation of chloramphenicol. Journal of Materials Science. 2021;56:1-16. 
  16. Geng B, Yang X, Li P, Shi W#, Pan D#, Shen L#. W-Doped TiO2 Nanorods for Multimode Tumor Eradication in Osteosarcoma Models under Single Ultrasound Irradiation. ACS Applied Materials & Interfaces. 2021;13(38):45325-34. 
  17. Geng B, Li P, Fang F, Shi W, Glowacki J, Pan D#, Shen L#. Antibacterial and osteogenic carbon quantum dots for regeneration of bone defects infected with multidrug-resistant bacteria. Carbon. 2021;184:375-85. 
  18. Geng B, Fang F, Li P, Xu S, Pan D#, Zhang Y#, Shen L#. Surface charge-dependent osteogenic behaviors of edge-functionalized graphene quantum dots. Chemical Engineering Journal. 2021;417:128125. 
  19. Su Y, Shen L*, Xue J, Zou J, Wan D, Shi Z, Therapeutic evaluation of galangin on cartilage protection and analgesic activity in a rat model of osteoarthritis, Electronic Journal of Biotechnology, 2021(53):8-13. 
  20. Geng B, Shen W, Fang F, Qin H, Li P, Wang X, Pan D#, Shen L#. Enriched graphitic N dopants of carbon dots as F cores mediate photothermal conversion in the NIR-II window with high efficiency. Carbon. 2020;162:14. 
  21. Geng B, Qin H, Shen W, Li P, Fang F, Li X, Pan D#, Shen L#. Carbon dot/WS2 heterojunctions for NIR-II enhanced photothermal therapy of osteosarcoma and bone regeneration. Chemical Engineering Journal. 2020;383:123102. 
  22. Xu Q, Song Z, Ji S, Xu G, Shi W#, Shen L#. The photocatalytic degradation of chloramphenicol with electrospun Bi2O2CO3-poly(ethylene oxide) nanofibers: the synthesis of crosslinked polymer, degradation kinetics, mechanism and cytotoxicity. RSC Advances. 2019;9(51):29917-26. 
  23. Su Y, Shen L*, Xue J, Zou J, Wan D, Shi Z, Therapeutic evaluation of galangin on cartilage protection and analgesic activity in a rat model of osteoarthritis, Electronic Journal of Biotechnology, 2021(53):8-13. 
  24. Shen L, Jiang C, An Z#. Open reduction through a posterior incision in the surgical treatment of shoulder posterior dislocation associated with proximal humeral fractures. ANZ J Surg. 2019;89(4):334-8. doi: 10.1111/ans.15147. 
  25. Geng B, Shen W, Li P, Fang F, Qin H, Li X, Pan D, Shen L#. Carbon Dot-Passivated Black Phosphorus Nanosheet Hybrids for Synergistic Cancer Therapy in the NIR-II Window. ACS Appl Mater Interfaces. 2019;11(48):44949-60. 
  26. Geng B, Qin H, Zheng F, Shen W, Li P, Wu K, Pan D#, Shen L#. Carbon dot-sensitized MoS2 nanosheet heterojunctions as highly efficient NIR photothermal agents for complete tumor ablation at an ultralow laser exposure. Nanoscale. 2019;11(15):7209-20. 
  27. Shen L, Yuan T, Chen S, Xie X#, Zhang C#. The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res. 2017;12(1):16. 
  28. Shen L, Li X, Wang T, Luo C, Zeng B, Ding J#. Reverse polyaxial less invasive stabilization systems for treatment of femoral intertrochanteric fractures of the distal femur. Arch Orthop Trauma Surg. 2016;136(11):1531-7. 
  29. Shen L, Tang J, Luo C, Xie X, An Z#, Zhang C#. Comparison of operative and non-operative treatment of acute undisplaced or minimally-displaced scaphoid fractures: a meta-analysis of randomized controlled trials. PLoS One. 2015;10(5):e0125247. 
  30. Xie X, Xie X, Qin H, Shen L#, Zhang C#. Comparison of internal and external fixation of distal radius fractures. Acta Orthop. 2013;84(3):286-91. 
  31. Shen L, Glowacki J, Zhou S. Inhibition of adipocytogenesis by canonical WNT signaling in human mesenchymal stem cells. Exp Cell Res. 2011;317(13):1796-803. 
  32. Shen L, Zhou S, Glowacki J. Effects of age and gender on WNT gene expression in human bone marrow stromal cells. J Cell Biochem. 2009;106(2):337-43. 
  • 01/01/2024-12/31/2027
    National Natural Science Foundation of China (General Program), ¥530,000, 12375345
    The effects and mechanism of a composite gel system modified by electron beam irradiation on tendon repair 
    Role: Project leader
  • 01/10/2023-09/30/2028
    Transverse Program, ¥2,500,000
    Integrated graphene quantum dots for promoting bone differentiation, broad-spectrum antibacterial, and fluorescent tracing in the repair of infectious bone and soft tissue defects 
    Role: Project leader
  • 01/04/2022-03/31/2025
    Shanghai Natural Science Foundation (General Program), ¥200,000, 22ZR1447600
    Research on the application of multifunctional integrated graphene quantum dots in bone repair engineering
    Role: Project leader
  • 01/01/2022-12/31/2025
    National Natural Science Foundation of China (General Program), ¥610,000, 12175142
    A novel antibacterial dressing modified by electron beam irradiation to promote wound healing 
    Role: Project leader
  • 10/01/2021-09/31/2024
    Shanghai Sixth People's Hospital Foundation (General Program), ¥300,000, YNMS202103
    A study on the repair of bone defects using amphiphilic graphene quantum dots based on promoting bone differentiation and antibacterial effects 
    Role: Project leader
  • 01/01/2013-12/31/2015
    National Natural Science Foundation of China (Youth Program), ¥230,000, 81201440
    Mechanism of WNT13 on the regulation of differentiation of bone marrow stromal cells in the type Ⅱ osteoporosis 
    Role: Project leader
  1. [Longxiang Shen, Qingcheng Yang, Bijiang Geng, et al] (2023), “A nitrogen doped carbon dot/lithium iron phosphate heterojunction, preparation method and application”, Shanghai: CN114177290B
  2. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2023), “A method for preparing graphene quantum dots”, Shanghai: CN110540192B
  3. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2023), “A graphene quantum dot/hydrogel composite, its preparation method and application”, Shanghai: CN111961227B
  4. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2023), “A metal ion coordinated carbon dot/titanium dioxide heterojunction and its preparation method and application”, Shanghai: CN113648414B
  5. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2022), “Preparation method of a carbon dot/titanium carbide heterojunction acoustic sensitizer and its application in sonodynamic cancer treatment”, Shanghai: CN112535731B
  6. [Longxiang Shen, Qinqing Wang, Wenyan Shi] (2022), “Preparation method of electron beam irradiation cross-linked calcium peroxide carbon quantum dots @ zein soluble protein antibacterial film”, Shanghai: CN112647193B
  7. [Longxiang Shen, Dengyu Pan, Bijiang Geng] (2022), “Preparation method and application of near-infrared responsive carbon dots”, Shanghai: CN110066654B
  8. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2022), “Carbon quantum dot hydrogel composite scaffold material, preparation method and application”, Shanghai: CN113398334B
  9. [Longxiang Shen, Jiezhi Dai, Yunzhong Shi] (2022), “A hip joint treatment plaster fixation device”, Shanghai: CN216603218U
  10. [Longxiang Shen, Yilan Zhou, Wenshuai Ji, et al] (2022), “A Kirschner wire internal fixation guide device for children with supracondylar fractures of the humerus”, Shanghai: CN216060712U
  11. [Longxiang Shen, Qingcheng Yang, Bijiang Geng, et al] (2022), “A nitrogen doped carbon dot/lithium iron phosphate heterojunction, preparation method and application”, Shanghai: CN114177290A
  12. [Longxiang Shen, Jianfei Tang, Wenshuai Ji, et al] (2022), “A surgical knee joint restraint device”, Shanghai: CN215937872U
  13. [Longxiang Shen, Zhiquan An, Congfeng Luo] (2022), “An anatomical locking plate for vertically unstable pubic symphysis separation”, Shanghai: CN215503331U
  14. [Longxiang Shen, Dengyu Pan] (2021), “Preparation method and application of a yellow fluorescent biological imaging material”, Shanghai: CN110272359B
  15. [Longxiang Shen, Jing Chen, Dongsheng Cheng, et al] (2021), “A suction device and electric knife integrated surgical device”, Shanghai: CN215079565U
  16. [Longxiang Shen, Wenshuai Ji, Jianfei Tang, et al] (2021), “A surgical fracture reduction forceps”, Shanghai: CN214857360U
  17. [Longxiang Shen, Jianwei Wang, Yamin Li, et al] (2021), “An anatomical locking plate for the foot navicular bone”, Shanghai: CN214857347U
  18. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2021), “A metal ion coordinated carbon dot/titanium dioxide heterojunction and its preparation method and application”, Shanghai: CN113648414A
  19. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2021), “Carbon quantum dot water gel composite scaffold materials, preparation methods and applications”, Shanghai: CN113398334A
  20. [Longxiang Shen, Wenshuai Ji, Xing Yan, et al] (2021), “A surgical scapular area inflation device”, Shanghai: CN213346616U
  21. [Longxiang Shen, Qinqing Wang, Wenyan Shi] (2021), “Preparation method of electron beam irradiation cross-linked calcium peroxide carbon quantum dots @ zein soluble protein antibacterial film”, Shanghai: CN112647193A
  22. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2021), “Preparation method of a carbon dot/titanium carbide heterojunction acoustic sensitizer and its application in sonodynamic cancer treatment”, Shanghai: CN112535731A
  23. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2021), “A graphene quantum dot/hydrogel composite, its preparation method and application”, Shanghai: CN111961227A
  24. [Longxiang Shen, Bijiang Geng, Dengyu Pan] (2019), “A method for preparing graphene quantum dots”, Shanghai: CN110540192A
  25. [Longxiang Shen, Dengyu Pan] (2019), “Preparation method and application of a yellow fluorescent biological imaging material”, Shanghai: CN110272359A
  26. [Longxiang Shen, Dengyu Pan, Bijiang Geng] (2019), “Preparation method and application of near-infrared responsive carbon dots”, Shanghai: CN110066654A

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