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SHEN Hao  

  • Chief Physician, Doctoral Supervisor
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Clinical research on joint replacement and revision. Clinical research on prosthetic joint infection. Molecular mechanisms study and related applications of Staphylococcus aureus-induced orthopedic implant infections
  • Contact: shen3hao@163.com; shenhao7212@shsmu.edu.cn
Biography Positions Publications Research Projects Patents
  • Visiting Assistant Professor, University of California, San Francisco, Division of Infectious Diseases, 2012-2013
  • PhD from Shanghai Jiao Tong University School of Medicine, 2011-2014
  • Master's Degree from Shanghai Jiao Tong University School of Medicine, 1996-1999
  • Bachelor's Degree from Shanghai Jiao Tong University School of Medicine, 1991-1996
  • Vice Director, Department of Orthopedics, Shanghai Sixth People's Hospital
  • Member, Joint Study Group of the Orthopedic Branch of Shanghai Medical Association
  • Member, Orthopedic Rehabilitation Professional Committee of Shanghai Rehabilitation Medicine Association
  • Deputy Chair, Joint Working Group of the Orthopedic Branch of Shanghai Medical Association
  • Member, Special Committee on Artificial Joint Infections of Chinese Medical Doctor Association Orthopedic Branch
  • Deputy Director, Bone and Joint Engineering Special Committee of Shanghai Biomedical Engineering Society
  • Deputy Chair, Joint Disability Reconstruction and Rehabilitation Group of Orthopedic Branch of Chinese Medical Doctor Association
  • Standing Committee Member, Complications Special Committee of China Association of Medical Education
  • Member, Special Committee on Orthopedic Innovation and Transformation of  China Research Hospital Association
  1. Jiang, F.;  Wang, J.;  Ren, Z.;  Hu, Y.;  Wang, B.;  Li, M.;  Yu, J.;  Tang, J.;  Guo, G.;  Cheng, Y.;  Han, P.; Shen, H., Targeted Light-Induced Immunomodulatory Strategy for Implant-Associated Infections via Reversing Biofilm-Mediated Immunosuppression. ACS nano 2024, 18 (9), 6990-7010.
  2. Guo, G.;  Liu, Z.;  Yu, J.;  You, Y.;  Li, M.;  Wang, B.;  Tang, J.;  Han, P.;  Wu, J.; Shen, H., Neutrophil Function Conversion Driven by Immune Switchpoint Regulator against Diabetes-Related Biofilm Infections. Advanced materials (Deerfield Beach, Fla.) 2024, 36 (8), e2310320.
  3. Hamushan, M.;  Yu, J.;  Jiang, F.;  Wang, B.;  Li, M.;  Hu, Y.;  Wang, J.;  Wu, Q.;  Tang, J.;  Han, P.; Shen, H., Adaptive evolution of the Clf-Sdr subfamily contributes to Staphylococcus aureus musculoskeletal infection: Evidence from comparative genomics. Microbiological research 2024, 278, 127502.
  4. Yu, J.;  Wang, M.; Shen, H., Intermuscular Fat, But Not Subcutaneous Fat, Correlated With Major Complications After Primary Total Hip Arthroplasty. Academic radiology 2023, 30 (7), 1367-1373.
  5. Wang, B.;  Wang, Q.;  Hamushan, M.;  Yu, J.;  Jiang, F.;  Li, M.;  Guo, G.;  Tang, J.;  Han, P.; Shen, H., Trends in microbiological epidemiology of orthopedic infections: a large retrospective study from 2008 to 2021. BMC infectious diseases 2023, 23 (1), 567.
  6. Yu, J.;  Li, M.;  Wang, J.;  Hamushan, M.;  Jiang, F.;  Wang, B.;  Hu, Y.;  Han, P.;  Tang, J.;  Guo, G.; Shen, H., Identification of Staphylococcus aureus virulence-modulating RNA from transcriptomics data with machine learning. Virulence 2023, 14 (1), 2228657.
  7. Yu, J.;  Wang, B.;  Zhang, F.;  Ren, Z.;  Jiang, F.;  Hamushan, M.;  Li, M.;  Guo, G.; Shen, H., Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface. Molecular medicine (Cambridge, Mass.) 2023, 29 (1), 35.
  8. Jiang, F.;  Chen, Y.;  Yu, J.;  Zhang, F.;  Liu, Q.;  He, L.;  Musha, H.;  Du, J.;  Wang, B.;  Han, P.;  Chen, X.;  Tang, J.;  Li, M.; Shen, H., Repurposed Fenoprofen Targeting SaeR Attenuates Staphylococcus aureus Virulence in Implant-Associated Infections. ACS Cent Sci 2023, 9 (7), 1354-1373.
  9. Yang, C.;  Luo, Y.;  Shen, H.;  Ge, M.;  Tang, J.;  Wang, Q.;  Lin, H.;  Shi, J.; Zhang, X., Inorganic nanosheets facilitate humoral immunity against medical implant infections by modulating immune co-stimulatory pathways. Nature communications 2022, 13 (1), 4866.
  10. He, L.;  Zhang, F.;  Jian, Y.;  Lv, H.;  Hamushan, M.;  Liu, J.;  Liu, Y.;  Wang, H.;  Tang, J.;  Han, P.;  Burgin, D. J.;  Dickey, S. W.;  Shen, H.;  Li, M.; Otto, M., Key role of quorum-sensing mutations in the development of Staphylococcus aureus clinical device-associated infection. Clinical and translational medicine 2022, 12 (4), e801.
  • 01/01/2023-12/31/2026
    National Natural Science Foundation of China , ¥520,000, 82272511
    The mechanism and intervention research of DCLK1+ fibroblast-inhibiting implant interface microenvironment in golden staphylococcal infection.
    Role: Project leader
  • 06/01/2021-06/01/2024
    Shanghai Municipal Science and Technology Commission Special Project on Animals, ¥250,000, 21140904800
    Construction and application of a novel dual-fluorescence tracking mouse model for intra-articular plant infection.
    Role: Project leader
  • 03/01/2021-03/01/2026
    Collaborative project, ¥1,500,000, /
    Foundational and preclinical studies on innovative diagnostic and therapeutic technologies related to intra-articular plant infections.
    Role: Project leader
  1. [Shen Hao, Yang Rui] (2020), “An antibiotic bone cement hip joint spacer”, CN 211750285 U; ZL 2019 2 1738206.9
  2. [Shen Hao, Yang Rui] (2020), “An antibiotic bone cement knee joint spacer”, CN 211750286 U; ZL 2019 2 1739181.4
  3. [Shen Hao, Zhu Zhenxin, Zhou Dandan, Ni Wenlong, Wu Shunshun, Fang Li] (2022), “Sample containment device”, CN 15837305; ZL 202122209024.6

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