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SHEN Chengxing  

  • Chief Physician, Doctoral Supervisor, Professor
  • Department: Cardiology
  • Research Area: Internal Medicine (Cardiovascular Diseases)
  • Research Interests: Pathogenesis and treatment of coronary heart disease 
  • Contact: shencx@sjtu.edu.cn; shenchienx2@hotmail.com
Biography Positions Publications Research Projects Patents
  • Visiting Scholar, Interventional Cardiology, New York-Presbyterian Hospital/Columbia America, Jul. 2010~Aug. 2010 
  • Visiting Scholar, Interventional Cardiology, Vancouver general hospital Canada, Jul. 2009~Aug. 2009
  • Visiting Scholar, Fellow, St.Elizabeth hospital, Cardiovascular department, Saarlouis, Germanly, Apr. 2007~Oct.2007      
  • Visiting Scholar, Nuclear Cardiology, Clermont-Ferrand Hospital, France, Apr. 2005~July 2004
  • PhD＆MD from Zhongshan Hospital, Fudan University, Sept. 2000~Jul. 2003
  • MS from School of Medicine, Southeast University, Sept. 1992~Jul.1995
  • BS from School of Medicine, Southeast University, Sept.1985 ~Jul. 1990
  • Director of Heart Center, Shanghai Sixth People's Hospital
  1. Ye T, Chen C, Wang D, Huang C, Yan Z, Chen Y, Jin X, Wang X, Ding X and Shen C*. Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury. Nat Commun. 2024;15:1682.
  2. Wang D, Zhang Y, Ye T, Zhang R, Zhang L, Shi D, Li T, Xia G, Niu K, Zhao Z, Chen Y, Pan W, Liu L, Jin X and Shen C*. Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway. Int J Biol Sci. 2023;19:1299-1315.
  3. Ye T, Yan Z, Chen C, Wang D, Wang A, Li T, Yang B, Ding X and Shen C*. Lactoferrin attenuates cardiac fibrosis and cardiac remodeling after myocardial infarction via inhibiting mTORC1/S6K signaling pathway. Theranostics. 2023;13:3419-3433.
  4. Chen Y, Zhou ZF, Han JM, Jin X, Dong ZF, Liu L, Wang D, Ye TB, Yang BS, Zhang YP and Shen CX*. Patients with comorbid coronary artery disease and hypertension: a cross-sectional study with data from the NHANES. Ann Transl Med. 2022;10:745.
  5. Yang B, Zhu Y, Lu X and Shen C*. A Novel Composite Indicator of Predicting Mortality Risk for Heart Failure Patients With Diabetes Admitted to Intensive Care Unit Based on Machine Learning. Front Endocrinol (Lausanne). 2022;13:917838.
  6. Zhang Y, Wang D, Zhao Z, Liu L, Xia G, Ye T, Chen Y, Xu C, Jin X and Shen C*. Nephronectin promotes cardiac repair post myocardial infarction via activating EGFR/JAK2/STAT3 pathway. Int J Med Sci. 2022;19:878-892.
  7. Yang B, Xu S, Wang D, Chen Y, Zhou Z and Shen C*. ACEI/ARB Medication During ICU Stay Decrease All-Cause In-hospital Mortality in Critically Ill Patients With Hypertension: A Retrospective Cohort Study Based on Machine Learning. Front Cardiovasc Med. 2021;8:787740.
  8. Zhu S, Huang S, Xia G, Wu J, Shen Y, Wang Y, Ostrom RS, Du A, Shen C* and Xu C. Anti-inflammatory effects of alpha7-nicotinic ACh receptors are exerted through interactions with adenylyl cyclase-6. Br J Pharmacol. 2021;178:2324-2338. (Co-corresponding author)
  9. Gao C, Gao Y, Hang J, Wei M, Li J, Wan Q, Tao Y, Wu H, Xia Z, Shen C* and Pan J. Strain parameters for predicting the prognosis of non-ischemic dilated cardiomyopathy using cardiovascular magnetic resonance tissue feature tracking. J Cardiovasc Magn Reson. 2021;23:21. (Co-corresponding author)
  10. Yu M, Shen C, Dai X, Lu Z, Wang Y, Lu B and Zhang J. Clinical Outcomes of Dynamic Computed Tomography Myocardial Perfusion Imaging Combined With Coronary Computed Tomography Angiography Versus Coronary Computed Tomography Angiography-Guided Strategy. Circ Cardiovasc Imaging. 2020;13:e009775.(Co-first author)
  11. Chen Y, Shi J, Zhang Y, Miao J, Zhao Z, Jin X, Liu L, Yu L, Shen C* and Ding J. An injectable thermosensitive hydrogel loaded with an ancient natural drug colchicine for myocardial repair after infarction. J Mater Chem B. 2020;8:980-992. (Co-corresponding author)
  12. Wang D, Zhang Y and Shen C*. Research update on the association between SFRP5, an anti-inflammatory adipokine, with obesity, type 2 diabetes mellitus and coronary heart disease. J Cell Mol Med. 2020;24:2730-2735.
  13. Zhao Z, Zhang Y, Liu L, Chen Y, Wang D, Jin X and Shen C*. Metabolomics study of the effect of smoking and high-fat diet on metabolic responses and related mechanism following myocardial infarction in mice. Life Sci. 2020;263:118570.
  • 01/01/2023-12/31/2025
    National Key Research and Development Program of China, $1382760,SQ2022YFC2400204, Study on clinical diagnosis solution of coronary microcirculation disturbance based on domestic innovative magnetocardiograph
    Role: Project leader                                                                                                      
  • 01/01/2022-12/31/2025
    National Natural Science Foundation of China (General Program), $76041.35, 82171547
    The molecular mechanism of polarization of M1-like macrophage induced
    by aged cardiomyocyte-released secretory autophagosomes (CRAPs)
    Role: Project leader
  • 01/01/2019-12/31/2022
    National Natural Science Foundation of China (General Program), $77423.92, 81871105
    Mechanism of Chitinase 3-like Protein 1 (CHI3L1) regulating polarization of macrophage and its effect on cardiac fibrosis and aged cardiac function
    Role: Project leader
  • 01/10/2020-30/09/2022
    The major clinical research projects of three-year action plan of promote clinical skills and clinical innovation in municipal hospitals of ShenKang. $1036927.5, Antihypertensive treatment for outcome improvement in patients with coronary heart disease and isolated central hypertension: A multicenter randomized double-blind placebo-controlled trial. 
    Role: Project leader
  1. [Shen cheng xing, Han ji ming, Jin Xian, Liu Liang] (2022), “A diseased tissue removal and collection system”, PCT/CN202210139605.3

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