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MIAO Ya
- Graduate Supervisor, Associate Chief Physician
- Department: Geriatrics
- Research Area: Geriatrics
- Research Interests: Aging and cognitive impairment in old age
- Contact: nning-my@163.com
- PhD from Shandong University, 2005
- MD from Fourth Military Medical University, 2002
- BMed from Shandong Medical University, 1999
- Associate Chief Physician, Department of Geriatrics, Shanghai Sixth People's Hospital
- Lizhen Cheng#, Yi-xin Chen#, Donghao Guo#, Yuan Zhong, Wei Li, Yi-jia Lin, Ya Miao*. mTOR‑dependent TFEB activation and TFEB overexpression enhance autophagy‑lysosome pathway and ameliorate Alzheimer’s disease‑like pathology in diabetic encephalopathy. Cell Communication Signaling. 2023,21(1):91.
- Yijia Lin#, Tingjun Hu#, Lizhen Cheng, Yixin Chen, Wei Li, Qihao Guo*, Ya Miao*. Causal Effects of Plasma Haptoglobin Levels on Alzheimer’s Disease: A Two-Sample Mendelian Randomization Study. Jounal of Alzheimer's Disease. 2023;95(1):339-348.
- Lizhen Cheng, Wei Li, Yi-xin Chen, Yi-jia Lin, Beiyun Wang, Qihao Guo*, Ya Miao*. The plasma Aβ as a biomarker for predicting Aβ-PET status in Alzheimer's disease:a systematic review with meta-analysis. Journal of Neurology Neurosurgery & Psychiatry. 2022, 93(5):513-520.
- Li-zhen Cheng , Wei Li , Yi-xin Chen , Yi-jia Lin , Ya Miao*. Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications. Aging and Disease. 2022, 13(2):447-457.
- Ya Miao, Liang Cui, Junpeng Li, Yixin Chen, Xiangqing Xie, Qihao Guo. Cognitive Improvement After Multi-Domain Lifestyle Interventions in an APOE ɛ4 Homozygous Carrier with Mild Cognitive Impairment: A Case Report and Literature Review. Jounal of Alzheimer's Disease. 2022;89(4):1131-1142.
- Donghao Guo, Lizhen Cheng, Yun Shen, Wei Li, Qinjie Li, Yuan Zhong*, Miao Ya*. 6-Bromoindirubin-3’-oxime (6BIO) Prevents Myocardium from Aging by Inducing Autophagy. Aging (Albany NY). 2020，Dec 26;12(24):26047-26062.
- Guo Donghao, Shen Yun, Li Wei, Li Qinjie, Miao Ya*, Zhong Yuan*. Upregulation of flavin-containing monooxygenase 3 mimics calorie restriction to retard liver aging by inducing autophagy. Aging (Albany NY). 2020 Jan 11;12(1):931-944.
- Donghao Guo, Yun Shen, Wei Li, Beiyun Wang, Qinjie Li, Yu Zhao, Chenhao Pan, Bi Chen, Yuan Zhong* and Ya Miao *. 6-Bromo-indirubin-3‘-oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver [J]. Frontiers in Pharmacology，2019,4(10):1-11.
- Ya Miao#, Donghao Guo#, Wei Li, Yuan Zhong*. Diabetes promotes development of Alzheimer’s disease through suppression of autophagy [J]. Journal of Alzheimer‘s Disease，2019, 69:289-296.
- Yuan Zhong#, Yitong Zhu#, Ting He, Wei Li, Qinjie Li, Ya Miao*. Brain derived neurotrophic factor inhibits hyperglycemia induced apoptosis and downregulation of synaptic plasticity related proteins in hippocampal neurons via the PI3K/Akt pathway [J]. Int J Mol Med. 2019,43: 294-304.
- 07/01/2023-06/30/2026
Shanghai Municipal Health Commission, ¥100,000, No.202340080
The Role of Blood transcriptomic Analysis in Predicting amyloid Deposition in the Brain.
Role: Project leader - 10/01/2022-09/30/2025
Basic research project of Shanghai Sixth People's Hospital, ¥300,000, No. ynms202207
Study on the role and mechanism of mitochondrial autophagy in microglial NLRP3 inflammatome Activation in diabetic encephalopathy based on TFEB/Parkin Regulation.
Role: Project leader - 01/01/2014-12/31/2016
National Natural Science Foundation of China, ¥230,000, No.81300933
Relationship between PDE4 and cAMP/PKA/CREB Signaling Pathways and Diabetic Encephalopathy.
Role: Project leader - 01/01/2012-12/31/2013
Shanghai Jiaotong University Interdisciplinary Study Foundation Medicine and Engineering, ¥100,000, No. YG2011MS46
An electroencephalogram analysis with Hidden Markov Model in the diagnosis of the elderly with mild cognitive impairment.
Role: Project leader
