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MENG Shengxi  

  • Graduate Supervisor, Associate Chief Physician
  • Department: Traditional Chinese Medicine
  • Research Area: Integrated Traditional Chinese and Western Medicine
  • Research Interests: Encephalopathy of Traditional Chinese Medicine
  • Contact: mengsx163@163.com
Biography Publications Research Projects Patents
  • PhD from Shanghai University of Traditional Chinese Medicine,2014
  • Master's degree from Henan University of Traditional Chinese Medicine,2010
  • Bachelor's degree from Henan University of Traditional Chinese Medicine,1996
  1. Meng S, Chen H, Deng C, Meng Z. Catalpol Mitigates Alzheimer's Disease Progression by Promoting the Expression of Neural Stem Cell Exosomes Released miR-138-5p. Neurotox Res. 2023 Feb;41(1):41-56. doi: 10.1007/s12640-022-00626-z. 
  2. Deng C, Meng Z, Chen H, Meng S（corresponding author）. Tetramethylpyrazine ameliorates systemic streptozotocin-induced Alzheimer-like pathology. J Chem Neuroanat. 2023 Jan;127:102207. doi: 10.1016/j.jchemneu.2022.102207. 
  3. Meng S, Wang B, Li W. LncRNA MALAT1 improves cerebral ischemia-reperfusion injury and cognitive dysfunction by regulating miR-142-3p/SIRT1 axis. Int J Neurosci. 2023 Jul;133(7):740-753. doi: 10.1080/00207454.2021.1972999.
  4. Chen H, Deng C, Meng Z, Meng S（corresponding author）. Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism. Front Endocrinol (Lausanne). 2023 May 16;14:956772. doi: 10.3389/fendo.2023.956772.
  5. Menghan Li, Jing Yuan, Qinghua Yang, Zhuoni Liu, Meng S（corresponding author）, Xiaoyong Wang, Changjun Peng, Tianxiang Yin.*. Therapeutic deep eutectic solvents based on natural product matrine and caprylic acid Physical properties, cytotoxicity and formation of surfactant free microemulsion. J. Drug Deliver. Sci. Tech., 2023, 90, 105177.
  6. Deng C, Chen H, Meng Z, Meng S（corresponding author）. Roles of traditional chinese medicine regulating neuroendocrinology on AD treatment. Front Endocrinol (Lausanne). 2022 Sep 21;13:955618. doi: 10.3389/fendo.2022.955618.
  7. Meng Z, Chen H, Deng C, Meng S（corresponding author）. Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma. Front Endocrinol (Lausanne). 2022 Aug 16;13:916328. doi: 10.3389/fendo.2022.916328.
  8. Meng S, Li S, Chen H, Deng C, Meng Z, Wang Y. Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer's Disease[J]. Evid Based Complement Alternat Med.2022，Aug 2;2022:5912396. doi: 10.1155/2022/5912396.
  9. Deng C, Chen H, Meng Z, Meng S(corresponding author). Gastrodin and Vascular Dementia: Advances and Current Perspectives[J].Evid Based Complement Alternat Med,2022 Apr 12;2022:2563934. doi: 10.1155/2022/2563934.
  10. Chen H, Deng C, Meng Z, Meng S（corresponding author）. Effects of Catalpol on Alzheimer's Disease and Its Mechanisms[J]. Evid Based Complement Alternat Med, 2022 Jun 30;2022:2794243. doi: 10.1155/2022/2794243. 
  11. Meng S, Wang B, Li W. CircAXL Knockdown Alleviates Aβ1-42-Induced Neurotoxicity in Alzheimer's Disease via Repressing PDE4A by Releasing miR-1306-5p. Neurochem Res. 2022 Jun;47(6):1707-1720. doi: 10.1007/s11064-022-03563-7. 
  12. Meng S, Li S, Chen H, et al. Metabolomics Deciphering the Potential Biomarkers of Hengqing I Prescription against Vascular Dementia[J]. Evid Based Complement Alternat Med, 2022 Mar 30;2022:1636145. doi: 10.1155/2022/1636145.
  13. Meng Z, Chen H, Deng C, Meng S(corresponding author). Multiple Roles of Paeoniflorin in Alzheimer's Disease[J].Evid Based Complement Alternat Med, 2022 Apr 11;2022:2464163. doi: 10.1155/2022/2464163.
  14. Chen H, Deng C, Meng Z, Meng S(corresponding author). Research Progress of Targeting Neuro-Immune Inflammation in the Treatment of Alzheimer's Disease. Front Biosci (Landmark Ed). 2022 Nov 25;27(11):312. doi: 10.31083/j.fbl2711312. 
  15. Meng Z, Chen H, Meng S（corresponding author）. The Roles of Tetramethylpyrazine During Neurodegenerative Disease[J]. Neurotox Res. 2021 Aug 5. doi: 10.1007/s12640-021-00398-y. 
  16. Shengxi Meng (corresponding author), Bing Wang , Wentao Li. Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice. Journal of Integrative Neuroscience.2021，December 30，20（4）:1001-1010. DOI:10.31083/j.jin2004101. 
  17. Meng SX, Wang B, Li WT. Serum expression of EAAT2 and ADORA2A in patients with different degrees of Alzheimer's disease[J].Eur Rev Med Pharmacol Sci,2020，24(22):11783-11792.doi: 10.26355/eurrev_202011_23833. 
  18. Meng SX,, Wang B, Li WT. Intermittent hypoxia improves cognition and reduces anxiety-related behavior in APP/PS1 mice. Brain Behav. 2020 Feb;10(2):e01513. doi: 10.1002/brb3.1513. Epub 2019 Dec 26. PMID: 31877583; PMCID: PMC7010588.
  • 01/01/2022-12/31/2024
    National Natural Science Foundation of China (Key Program), ¥3,180,200, 3213XXXX
    Systematic characterizations of XXXXXXX
    Role: Principal Investigator
  • 01/01/2022-12/31/2023
    Shanghai Sixth People's Hospital Medical Service Level Improvement Project, ¥30,000, 20220213
    Clinical efficacy and safety evaluation of repeated transcranial magnetic stimulation combined with auricular point pressing pills and auricular point massage in the treatment of Alzheimer's disease 
    Role: Project leader
  • 06/01/2022-12/31/2023
    COVID-19 Emergency Response Project of Shanghai Sixth People's Hospital in 2022, ¥50,000, 20220213
    Clinical application of Zijin Prescription in prevention and treatment of COVID-19 
    Role: Project leader
  • 03/30/2019-03/30/2022
    Project of Shanghai science and technology commission, ¥200,000, 19401932500
    Vascular dementia treatment with HengqingⅠformula:A multicenter randomized double-blind parallel-group place-controlled study 
    Role: Project leader
  • 09/01/2019-06/30/2022
    Project of Shanghai science and technology commission, , ¥500,000, 19401970600
    Intervention of ischemic stroke with cerebral lobe microhemorrhag with Hengqing Ⅲ formula:A randomized double-blind parallel-group placebo-controlled trial, 
    Role: Project leader
  • 09/01/2018-12/31/2020
    Shanghai municipal government will further accelerate the three-year action plan for the development of TCM (2018-2020) for major clinical research on TCM, ¥150,000, ZY (2018-2020)-cccx-4010
    To explore biomarkers of cerebrovascular disease with kidney deficiency and blood stasis syndrome based on metabolomics and new clinical research strategy of integrated traditional Chinese and western medicine, 
    Role: Project leader
  • 11/01/2018-10/31/2020
    Innovation fund of integrated traditional Chinese and western medicine, school of medicine, Shanghai Jiao Tong university, ¥150,000, 18zxy002
    Analysis of urinary specific metabolites in patients with vascular dementia with kidney deficiency and phlegm stasis syndrome and intervention study of HengqingⅠformula, 
    Role: Project leader
  1. [Shengxi Meng, Zeyu Meng] (2021), “A traditional Chinese medicine monomer composition for the prevention and treatment of Alzheimer's disease and its application”, ZL 202011556436.0.
  2. [Shengxi Meng, Xuefeng Peng] (2021), “Traditional Chinese medicine composition and preparation method for treating Alzheimer's disease”, ZL 201910371018.5.

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