LIU Shen  

  • Doctoral Supervisor, Professor, Deputy Chief Physician, Researcher
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Pathogenesis and therapy of tendon injury
  • Contact: liushensjtu@126.com
  • Postdoc, Johns Hopkins University, 2018
  • PhD from Shanghai Jiao Tong University School of Medicine, 2013
  • MPH from Shanghai Jiao Tong University School of Medicine, 2009
  • Deputy Executive Director, National Center for Orthopedics, Shanghai Sixth People's Hospital
  • Life Member, International Chinese Musculoskeletal Research Society                                                                                          
  • Secretary, China Division of Asian Pacific Federation of Societies for Reconstructive Microsurgery
  • Promotion Editor, Nano-Micro Letters (SCI, IF 26.6)                                                                                          
  • Associate Editors, Front Bioeng Biotech (SCI, IF 5.7)                             
  1. Wang S, Xiao Y, Tian J, Dai B, Tao Z, Liu J, Sun Z, Liu X, Li Y, Zhao G, Cui Y, Wang F, Liu S. Targeted Macrophage CRISPR-Cas13 mRNA Editing in Immunotherapy for Tendon Injury. Adv Mater. 2024 (IF=29.4)  
  2. Tu K, Bao R, Wang L, Guo Z, Jiang C, Su Y, Liu S, Liu J. Neuromorphic Electro-Stimulation Based on Atomically Thin Semiconductor for Damage-Free Inflammation Inhibition. Nat Commun. 2024 (IF=16.6)  
  3. Bao R, Wang S, Liu X, Tu K, Liu J, Huang X, Liu C, Zhou P, Liu S. Stimulation of Sympathetic Nerve via Ultraflexible Cuff Electrodes Inhibits Inflammation Caused by Tendon Rupture. Adv Funct Mater. 2024 (IF=19)   
  4. Xiao Y, Han C, Wang Y, Zhang X, Bao R, Li Y, Chen H, Hu B, Liu S. Interoceptive Regulation of Skeletal Tissue Homeostasis and Repair. Bone Res. 2023 (IF=12.7)   
  5. Li Y, Wang X, Hu B, Sun Q, Wan M, Carr A, Liu S, Cao X. Macrophage derived TGFβ1 recruit mesenchymal stem cell for peritendinous adhesion. Bone Res. 2023 May 8;11(1):24. doi: 10.1038/s41413-023-00252-1. (IF=12.7) 
  6. Cai C, Zhang X, Li Y, Liu X, Wang S, Lu M, Yan X, Deng L, Liu S, Wang F, Fan C. Self-Healing Hydrogel Embodied with Macrophage-Regulation and Responsive-Gene-Silencing Properties for Synergistic Prevention of Peritendinous Adhesion. Adv Mater. 2022; 34(5): e2106564; doi: 10.1002/adma.202106564. (IF=29.4)  
  7. Wang X, Liu S, Yu T, An S, Deng R, Tan X, Crane J, Zhang W, Pan D, Wan M, Carr A, Cao X*. Inhibition of Integrin αvβ6 Activation of TGF-β Attenuates Tendinopathy. Adv Sci. 2022 (IF=15.1) 
  8. Wang S, Lu M, Wang W, Yu S, Yu R, Cai C, Li Y, Shi Z, Zou J, He M, Xie W, Yu D, Jin H, Li H, Xiao W, Fan C, Wu F, Li Y, Liu S. Macrophage Polarization Modulated by NF-κB in Polylactide Membranes-Treated Peritendinous Adhesion. Small. 2022; 18(13): e2104112; doi: 10.1002/smll.202104112. (IF=13.3)  
  9. Li Y, Yu Q, Ling Z, Chen H, Liu X, Wu T, Hu B, Fan C, Jiang X, Liu S. Novel enzyme-sensitive poly-tioxolone membranes for peritendinous anti-adhesion. Compos Part B-Eng. 2022; 238: 109904; https://doi.org/10.1016/j.compositesb.2022.109904 (IF=13.1) 
  10. Cai C, Wang W, Liang J, Li Y, Lu M, Cui W, Fan C, Deng L, Li Y, Wang F, Liu S. MMP-2 Responsive Unidirectional Hydrogel-Electrospun Patch Loading TGF-β1 siRNA Polyplexes for Peritendinous Anti-Adhesion. Adv Funct Mater 2021; 31(6): 2008364; doi: 10.1002/adfm.202008364. (IF=19.924)
  • 2022-04~2025-03
    Shanghai 2022 "Science and Technology Innovation Action Plan" natural Science Foundation(Original exploration Program),¥500000,22ZR1480300
    Macrophage-derived TGFβ1 regulates BMSCS-derived myoblast IL11 autocrine loop mediated by TGFβ1
    Role: Project leader
  • 2022-01~2025-12
    National Natural Science Foundation of China (General Program), ¥550000, 82172408
    The role and mechanism of BMSCs differentiation mediated by HIF1α/SMAD7/SMAD3 loop in tendon adhesion
    Role: Project leader
  • 2021-09~2024-08
    Excellent academic leader of Shanghai 2021 "Science and Technology Innovation Action Plan",¥400000 ,21XD1422900
    Mmp2-sensitive IL11-siRNA release/self-healing/composite anti-adhesion membrane interferes with tendon adhesion
     Role: Project leader
  • 2020-10~2022-09
    Shenkang Development Center,¥500000,SHDC2020CR4032
    A Prospective Randomized Controlled Trial for Ultrasound-guided Delayed Injection of Hydrogel for Prevention and Treatment of Tendon Adhesion
    Role: Project leader    
  • 2020-10~2022-09                                                                                                                                                
    Shanghai Jiao Tong University School of Medicine,¥1000000                                                               
    Study on the effect and mechanism of bidirectional sensitive trigger bionic tendon sheath membrane in preventing tendon adhesion
    Role: Project leader
  • 2020-01~2022-12
    National Natural Science Foundation of China(Excellent Young Scientists Fund),¥1200000,81922045
    Tendon adhesion after limb injury
    Role: Project leader
  • 2018-01~2020-12
    Shanghai Youth Top talent program,¥150000                             
    Experimental study on the regulation of selective activation of macrophages by anti-adhesion membrane
    Role: Project leader                          
  • 2018-01~2021-12
    National Natural Science Foundation of China (General Program),¥550000,81772314
    Study on the mechanism and intervention of biomimetic ganglion membrane regulating the classical activation of macrophages to prevent tendon adhesion
    Role: Project leader
  • 2017-07~2020-06
    Shanghai Municipal Health and Family Planning Commission outstanding young talents ,  ¥500000,2017YQ022
    Mechanism and intervention of macrophage NF-κB in preventing and treating tendon adhesion by anti-adhesion membrane
    Role: Project leader
  • 2014-01~2016-12
    Project supported by the Young Scientists Fund of the National Natural Science Foundation of China,¥230000,81301545
    Mechanism of bidirectional tissue-matched nanofiber membrane loaded with ERK2-siRNA to inhibit the proliferation of tendon adhesion tissue
    Role: Project leader  
  1. [Shen Liu,Wei Wang ,Guang wang Liu] (2023), “The utility model relates to a broken bone alignment device”, 201910891875.8
  2. [Shen Liu,Yuanyi Zheng,Xuanzhe Liu,Wenkun Bai] (2023), “Ultrasound treatment of hand tendon adhesion by gloves”, ZL202220693574.1
  3. [Cunyi Fan,Shen Liu,Wei Wang,Shiyang Yu,Lingchi Kong,XuWang] (2022), “Soft tissue auxiliary forming device and component”, CN217592994U
  4. [Shen Liu,Cunyi Fan,Chuandong Fan,Guangwang Liu] (2021), “A biomimetic tendon sheath membrane”, CN110368136B 
  5. [Shen Liu,Cunyi Fan,Chuandong Cai] (2019), “Finger tendon sheath brace”, ZL201921572546.9     

Translation Achievements:

  • An efficient and inexpensive device for fixing mice by batch infusion,ZL202022255314.X ¥65300
  • A distal humerus prosthesis structure,202111209499.3   Clinical application
  • A simple slicing device for frozen sections of tissue,202020166340.2 ¥61200
  • Finger tendon sheath brac;ZL201921572546.9 ¥1000000+3% of turnover can be obtained as commission, which cannot exceed a maximum of RMB 7.5 million
  • An artificial elbow joint surface replacement prosthesis,ZL201620193 294.9. Clinical application
  • A simple biomechanical experimental device for elbow joint,ZL201410411644.X Clinical application