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Research

LIAN Xiaofeng  

  • Chief Physician, Graduate Supervisor
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Spinal Cord Injury;   Infectious Spondylitis; Lumbar Disc Herniation; Cervical Spondylosis
  • Contact: xf909@126.com
Biography Positions Publications Research Projects
  • Postdoctoral Fellowship at Shanghai Sixth People's Hospital, 2010
  • Doctoral Degree of Medicine from Naval Medical University, 2007
  • Bachelor's Degree of Medicine from Naval Medical University, 1999
  • Deputy Director of Minimally Invasive Group, Orthopaedic Branch, Shanghai Medical Association
  • Standing Member and Secretary of the Spinal Cord Specialized Committee of the Shanghai Society of Rehabilitation Medicine
  • Member of Minimally Invasive Group of Orthopaedic Association of Shanghai Physicians Association
  • Member of Spinal Surgery Specialized Committee of Orthopedic Pine Society of Chinese Physicians Association
  • Secretary of Cervical Spine Group of Orthopedic Rehabilitation of Chinese Rehabilitation Medicine Association
  • Member of Shanghai Orthopedic Rehabilitation Committee
  • Member of the Spine Committee of Shanghai Society of Integrative Medicine and Western Medicine
  • Member of North American Society of Spine Surgery (NASS)
  • Member of International Society of Trauma and Orthopaedic Surgery (SICOT)
  • Member of AO Spine Association
  1. Wang Xin, Zhang Baokun, Chen Zhiheng, Shi Qiang, Yang Erzhu, Xu Jianguang, Lian Xiaofeng. Biodegradable bilayer hydrogel membranes loaded with bazedoxifene attenuate blood-spinal cord barrier disruption via the NF-κB pathway after acute spinal cord injury. Acta Biomaterialia, 2023, 159: 140-155. DOI: 10.1016/j.actbio.2023.01.056.
  2. Yuxuan Qian, Zhiheng Chen, Guowang Zhang, Xin Wang, Ji Liu, Aofei Yang, Jianguang Xu, Xiaofeng Lian. Transforaminal endoscopic lumbar discectomy using a 45° puncture angle and foraminotomy versus traditional THESYS for L5/S1 lumbar disc herniation: a prospective randomized controlledtrial. Eur Spine J. 2024 Feb;33(2):453-462. DOI: 10.1007/s00586-023-08117-1.
  3. Shengting Wu, Zhiheng Chen, Yinghao Wu, Qiang Shi, Erzhu Yang, Baokun Zhang, Yuxuan Qian, Xiaofeng Lian, Jianguang Xu. ADSC-Exos enhance functional recovery after spinal cord injury by inhibiting ferroptosis and promoting the survival and function of endothelial cells through the NRF2/SLC7A11/GPX4 pathway. BIOMEDICINE & PHARMACOTHERAPY, 2024, 172. DOI: 10.1016/j.biopha.2024.116225.
  4. Wang Xin, Shi Qiang, Ding Jianing, Liang Jiaming, Lin Fangqi, Cai Bin, Chen Yuanyuan, Zhang Guowang, Xu Jianguang, Lian Xiaofeng. Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Attenuate Blood-Spinal Cord Barrier Disruption via the TIMP2/MMP Pathway After Acute Spinal Cord Injury. Mol Neurobiol. 2021 Dec; 58(12):6490-6504. DOI: 10.1007/s12035-021-02565-w.
  5. Yang E, Zhang G, Xu J, Chen S, Wang H, Cao L, Liang B, Lian X. Activated Schwann cells and bone mesenchymal stem cells combined with multichannel polymer scaffold improve functional recovery after rat spinal cord injury. Acta Pharmacologica Sinica. 2017 May;38(5):623-637. DOI: 10.1038/aps.2017.11.
  6. Yi Zhang, Jinmei Chen, Xiaoli Yi, Zhiheng Chen, Ting Yao, Zhenghao Tang, Guoqing Zang, Xuejie Cao, Xiaofeng Lian, Xiaohua Chen. Evaluation of the metagenomic next-generation sequencing performance in pathogenic detection in patients with spinal infection. Front Cell Infect Microbiol. 2022 Oct 27;12:967584. DOI: 10.3389/fcimb.2022.967584.
  7. Shi T, Ruan Z, Wang X, Lian X, Chen Y. Erythrocyte membrane-enveloped molybdenum disulfide nanodots for biofilm elimination on implants via toxin neutralization and immune modulation. J Mater Chem B. 2022 Mar 16;10(11):1805-1820. DOI: 10.1039/d1tb02615a.
  8. Shen JJ, Wang X, Cai B, Chen YY, Zhang GW, Xu JG, Lian XF. Transforaminal endoscopic lumbar discectomy with targeted puncture and foraminotomy for very highly migrated disc herniation: A technique note with case series. Heliyon. 2022 Oct 17;8(10):e11115. DOI: 10.1016/j.heliyon.2022.e11115.
  9. Zhiheng Chen, Xin Wang, Xiaoyan Cui, Guowang Zhang, Jianguang Xu, Xiaofeng Lian. Transforaminal Versus Interlaminar Approach of Full-Endoscopic Lumbar Discectomy Under Local Anesthesia for L5/S1 Disc Herniation: A Randomized Controlled Trial. Pain Physician. 2022 Nov;25(8):E1191-E1198. PMID: 36375189. 
  10. Zhi-Heng Chen, Xin Wang, Yi Zhang, Sheng-Ting Wu, Ying-Hao Wu, Qiang Shi, Bao-Kun Zhang, Jian-Guang Xu, Xiao-Hua Chen, Xiao-Feng Lian. Percutaneous Transforaminal Endoscopic Debridement and Drainage with Accurate Pathogen Detection for Infectious Spondylitis of the Thoracolumbar and Lumbar Spine. World Neurosurg. 2022 Aug;164:e1179-e1189. DOI: 10.1016/j.wneu.2022.05.123.
  11. Liu XK, Li H, Xu JG, Yang EZ, Hou TS, Zeng BF, Lian XF.Surgical treatment of severe multilevel circumferential compressive myelopathy of the cervical spine: is circumferential procedure necessary?  Br J Neurosurg. 2017 31(2):189-193. DOI: 10.1080/02688697.2016.1238038.
  12. Yang EZ, Xu JG, Huang GZ, Xiao WZ, Liu XK, Zeng BF, Lian XF. Percutaneous Vertebroplasty Vs Conservative Treatment in Aged Patients with Acute Osteoporotic Vertebral Compression Fractures. Spine (Phila Pa 1976). 2016 41(8):653-60. DOI: 10.1097/BRS.0000000000001298.  
  13. Yang EZ, Xu JG, Liu XK, Jin GY, Xiao W, Zeng BF, Lian XF. An RCT study comparing the clinical and radiological outcomes with the use of PLIF or TLIF after instrumented reduction in adult isthmic spondylolisthesis. Eur Spine J. 2016 25(5):1587-1594. DOI: 10.1007/s00586-015-4341-z.
  • 01/01/2013-12/31/2016
    National Natural Science Foundation of China , ¥700,000, 81272001
    A comparative study on the repair of spinal cord injury using biological scaffolds with different three-dimensional structures
    Role: Project leader
  • 01/01/2021-12/31/2024
    The Foundation of Shanghai Municipal Health Commission , ¥100,000, 202040189
    A study of biomechanical changes before and after fusion surgery for lumbar spondylolisthesis
    Role: Project leader
  • 03/01/2023-12/31/2026
    The Natural Science Foundation of Shanghai of China , ¥200,000, 202303482
    Protective effect and mechanism of bilayer-structured HSPT composites loaded with Bazedoxifene on blood-spinal cord barrier after spinal cord injury via MAPK/NF-κB pathway
    Role: Project leader

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