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LIAN Xiaofeng  

  • Chief Physician, Doctoral Supervisor
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Spinal Cord Injury Infectious Spondylitis Lumbar Disc Herniation Cervical Spondylosis
  • Contact: lianxiaofeng@shsmu.edu.cn
Biography Positions Publications Research Projects Patents
  • Postdoctoral Fellowship from Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 2010
  • Doctor of Medicine from Naval Medical University, 2007
  • Bachelor's Degree of Medicine from Naval Medical University, 1999
  • Director, Specialty of Spine Surgery, Shanghai Sixth People's Hospital
  • Director, Center for Spinal Minimally Invasive Diagnosis and Treatment, Shanghai Sixth People's Hospital
  • Principal Investigator, The 14th Five-Year National Key Research and Development Program
  • Vice Chairman, Spinal Cord Committee of Shanghai Rehabilitation Medical Association
  • Deputy Leader, Minimally Invasive Group of Shanghai Orthopaedic Association
  • Leader, Minimally Invasive Group of the Spine Committee of Shanghai Society of Integrated Traditional Chinese and Western Medicine
  • Member, Minimally Invasive Group of Shanghai Orthopaedic Surgeons Association
  • Member, Orthopaedic Rehabilitation Committee of Shanghai Rehabilitation Medical Association
  • Secretary, Cervical Spine Disorders Group of the Orthopaedic Injury Rehabilitation Committee of Chinese Rehabilitation Medical Association
  • Member, Low Back Pain Group of the Pain Medicine Society of Shanghai Medical Association
  • Member, SICOT China Shanghai Chapter
  • Member, Committee of Orthopaedics and Traumatology of Shanghai Society of Integrated Traditional Chinese and Western Medicine
  • Member, Spine Committee of Shanghai Society of Integrated Traditional Chinese and Western Medicine
  1. Shengting Wu, Yuxuan Qian, Zhehao Fan, Qiushui Lin, Qiang Zhang, Zhiheng Chen, Xinkai Pu, Xiao Chen, Qingxin Guo, Ningfang Mao, Lixian Jiang, Jiacan Su, Xiaofeng Lian. Engineering NO delivery system renormalizes the excitability of inhibitory interneurons after spinal cord injury via chloride extrusio. Bioact Mater，2025 Jul 17:53:300-313. doi: 10.1016/j.bioactmat.2025.07.022.
  2. Xin Wang, Jianing Ding, Xiao Chen, Sicheng Wang, Zhiheng Chen, Yuanyuan Chen, Guowang Zhang, Ji Liu, Tingwang Shi, Jian Song, Shihao Sheng, Guangchao Wang, Jianguang Xu, Jiacan Su, Wei Zhang, Xiaofeng Lian. Light-activated nanoclusters with tunable ROS for wound infection treatment. Bioact Mater，2024 Jul 30:41:385-399. doi: 10.1016/j.bioactmat.2024.07.009.
  3. Zhiyuan Luo, Renjie Lu, Tingwang Shi, Zesong Ruan, Wenbo Wang, Zhao Guo, Zeming Zhan, Yihong Ma, Xiaofeng Lian, Cheng Ding, Yunfeng Chen. Enhanced Bacterial Cuproptosis-Like Death via Reversal of Hypoxia Microenvironment for Biofilm Infection Treatment. Adv Sci (Weinh), 2024 May;11(19):e2308850. doi: 10.1002/advs.202308850.
  4. Zhiheng Chen, Shengting Wu, Shihao Sheng, Sicheng Wang, Yuxuan Qian, Xin Wang, Fengjie Lu, Qi Han, Xiao Chen, Jiacan Su, Xiaofeng Lian. hUCMSC-derived exosomes mitigate blood-spinal cord barrier disruption by activating AMPK/mTOR-mediated autophagic flux after acute spinal cord injury. COMPOSITES PART B-ENGINEERING,  JAN 15 2025. DOI10.1016/j.compositesb.2024.111944
  5. Wang Xin, Zhang Baokun, Chen Zhiheng, Shi Qiang, Yang Erzhu, Xu Jianguang, Lian Xiaofeng. Biodegradable bilayer hydrogel membranes loaded with bazedoxifene attenuate blood-spinal cord barrier disruption via the NF-κB pathway after acute spinal cord injury. Acta Biomaterialia, 2023, 159: 140-155. DOI: 10.1016/j.actbio.2023.01.056.
  6. Yuxuan Qian, Zhiheng Chen, Guowang Zhang, Xin Wang, Ji Liu, Aofei Yang, Jianguang Xu, Xiaofeng Lian. Transforaminal endoscopic lumbar discectomy using a 45° puncture angle and foraminotomy versus traditional THESYS for L5/S1 lumbar disc herniation: a prospective randomized controlledtrial. Eur Spine J. 2024 Feb;33(2):453-462. DOI: 10.1007/s00586-023-08117-1.
  7. Shengting Wu, Zhiheng Chen, Yinghao Wu, Qiang Shi, Erzhu Yang, Baokun Zhang, Yuxuan Qian, Xiaofeng Lian, Jianguang Xu. ADSC-Exos enhance functional recovery after spinal cord injury by inhibiting ferroptosis and promoting the survival and function of endothelial cells through the NRF2/SLC7A11/GPX4 pathway. BIOMEDICINE & PHARMACOTHERAPY, 2024, 172. DOI: 10.1016/j.biopha.2024.116225.
  8. Wang Xin, Shi Qiang, Ding Jianing, Liang Jiaming, Lin Fangqi, Cai Bin, Chen Yuanyuan, Zhang Guowang, Xu Jianguang, Lian Xiaofeng. Human Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Attenuate Blood-Spinal Cord Barrier Disruption via the TIMP2/MMP Pathway After Acute Spinal Cord Injury. Mol Neurobiol. 2021 Dec; 58(12):6490-6504. DOI: 10.1007/s12035-021-02565-w.
  9. ZhiHeng Chen, Xin Wang, Yi Zhang, ShengTing Wu, YingHao Wu, Qiang Shi, BaoKun Zhang, JianGuang Xu, XiaoHua Chen, XiaoFeng Lian. Percutaneous Transforaminal Endoscopic Debridement and Drainage with Accurate Pathogen Detection for Infectious Spondylitis of the Thoracolumbar and Lumbar Spine. World Neurosurg. 2022 Aug;164:e1179-e1189. DOI: 10.1016/j.wneu.2022.05.123.
  10. Yang EZ, Xu JG, Huang GZ, Xiao WZ, Liu XK, Zeng BF, Lian XF. Percutaneous Vertebroplasty Vs Conservative Treatment in Aged Patients with Acute Osteoporotic Vertebral Compression Fractures. Spine (Phila Pa 1976). 2016 41(8):653-60. DOI: 10.1097/BRS.0000000000001298.  
  • 01/01/2026–12/31/2029
    National Natural Science Foundation of China, ¥490,000, 82572758
    Mechanism of DNase I‑Based Artificial Cells Regulating Neutrophil Extracellular Traps to Promote Neurovascular Coupling After Spinal Cord Injury
    Role: Project leader
  • 12/01/2024–11/30/2027
    The Natural Science Foundation of Shanghai of China, ¥600,000, 24SF1903400
    Clinical Application Demonstration of Additively Manufactured Interbody Fusion Cages in Spinal Fusion Surgery
    Role: Project leader
  • 12/01/2024–11/30/2027
    National Key Research and Development Program of China, ¥1,000,000, 2024YFC2419600
    Research on Key Technologies and Product Development of Ultra-micro Magnetic Imaging for Peripheral Nerve Conduction
    Role: Project leader
  • 07/01/2024–07/01/2025
    The Basic Medical Innovation Open Project of Naval Medical University, ¥150,000, JCKFKT-MS-012
    Indole-3-propionic acid promotes neural regeneration after spinal cord injury through immunomodulatory effects
    Role: Project leader
  • 04/01/2023-3/31/2026
    The Natural Science Foundation of Shanghai of China , ¥200,000, 23ZR1448100
    Protective effect and mechanism of bilayer-structured HSPT composites loaded with Bazedoxifene on blood-spinal cord barrier after spinal cord injury via MAPK/NF-κB pathway
    Role: Project leader
  • 01/01/2021-12/31/2023
    The Foundation of Shanghai Municipal Health Commission ，¥100,000, 202040189
    A study of biomechanical changes before and after fusion surgery for lumbar spondylolisthesis
    Role: Project leader
  • 01/01/2013-12/31/2016
    National Natural Science Foundation of China , ¥700,000, 81272001
    A comparative study on the repair of spinal cord injury using biological scaffolds with different three-dimensional structures
    Role: Project leader
  1. [Xiaofeng Lian, Kun Wang, Guowang Zhang, Zixi Zheng] (2025), “Application of A Titanium Mesh Component”,CN202522651483.8; ZL202522651483.8
  2. [Xiaofeng Lian, Zhiheng Chen, Xinkai Pu, Ruijie Ni, Xin Wang] (2025), “Application of Preparation and application of a hydrogen sulfide donor delivery system for repairing the blood-brain barrier in spinal cord injury”, CN202511709436.2
  3. [Xiaofeng Lian, Guowang Zhang, Kun Wang, Xinkai Pu, Haoxiang Lu] (2026), “Application of Helical Electrode Tip with Fluid Channel”, CN202620069826.1
  4. [Xiaofeng Lian, Xin Wang, Xinkai Pu, Zhiheng Chen, Haoxiang Lu] (2026), “Application of Anti-Electrode Dislodgement Radio Frequency Electrode Tip”, CN202620069828.0
  5. [Xiaofeng Lian] (2025), “Application of Liftable Support Device for Posterior Cervical Surgery”, CN202511451986.9
  6. [Xiaofeng Lian, Guowang Zhang, Xin Wang] (2025), “Application of Dual-Medium Visualization Channel System for Minimally Invasive Spinal Surgery”, CN2025221262474

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