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JIN Xian
- Chief Physician, Doctoral Supervisor, Professor
- Department: Cardiology
- Research Area: Internal medicine
- Research Interests: Mechanisms of injury and repair post acute myocardial infarction
- Contact: jinxianian@126.com
- PhD from Shanghai Jiao Tong University, 2016
- Master from Shanghai Jiao Tong University, 2004
- Bachelor from Shanghai Jiao Tong University, 2002
- Member of the Cardiovascular Disease Branch of the Shanghai Medical Association, Deputy Leader of the Structural Heart Disease Group
- Boshen Yang, Zhixiang Wang, Kaifan Niu, Taixi Li, Tingting Tong, Suiji Li, Liuhang Su, Yan Wang, Chengxing Shen, Xian Jin1#, Juan Song, Xia Lu. TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts. Cell Commun Signal 2024;22:444. https://doi.org/10.1186/s12964-024-01826-0.
- Boshen Yang, Taixi Li, Zhixiang Wang, Yuankang Zhu, Kaifan Niu, Sien Hu, Zhiqi Lin, Xinjie Zheng, Xian Jin#, Chengxing Shen. Ruxolitinib-based senomorphic therapy mitigates cardiomyocyte senescence in septic cardiomyopathy by inhibiting the JAK2/STAT3 signaling pathway. Int J Biol Sci 2024;20:4314–40. https://doi.org/10.7150/ijbs.96489.
- Tianbao Ye, Cheng Chen, Di Wang, Chengjie Huang, Zhiwen Yan, Yu Chen, Xian Jin#, Xiuyuan Wang, Xianting Ding & Chengxing Shen; Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury. Nature Communications, 2024, 15:1682. DOI: 10.1038/s41467-024-45927-3
- Di Wang; Yaping Zhang; Tianbao Ye; Runlei Zhang; Lili Zhang; Dongmei Shi; Taixi Li; Guofang Xia; Kaifan Niu; Zhe Zhao; Yu Chen; Weijun Pan; Liang Liu; Xian Jin#; Chengxing Shen; Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway. International Journal of Biological Sciences, 2023. 19(4): p. 1299-1315. DOI: 10.7150/ijbs.79260
- Tianbao Ye; Boshen Yang; Peng Wei; Kaifan Niu; Taixi Li; Di Wang; Yaping Zhang; Yu Chen; Chengxing Shen; Xiaoqing Wang; Xian Jin#; Liang Liu; Cardiac Overexpression of Chil1 Improves Wound Healing to Prevent Cardiac Rupture After Myocardial Infarction, Journal of Cardiovascular Translational Research, 2023;16(3):608-623. DOI: 10.1007/s12265-022-10328-8
- Yang Boshen; Zhu Yuankang; Li Taixi; Niu kaifan; Wang Zhixiang; Liu Liang; Shen Chengxing; Lu Xia; and Jin Xian#; Effects of ondansetron treatment on outcomes of critically ill patients with myocardial infarction partly through its anti-inflammatory activity. Int J Med Sci. 2023;20(6):709-716. DOI: 10.7150/ijms.81797
- Yaping Zhang; Di Wang; Zhe Zhao; Liang Liu; Guofang Xia; Tianbao Ye; Yu Chen; Congfeng Xu; Xian Jin#; Chengxing Shen; Nephronectin promotes cardiac repair post myocardial infarction via activating EGFR/JAK2/STAT3 pathway, Ivyspring International Publisher, 2022, 19(5): 878. DOI: 10.7150/ijms.71780
- Zhe Zhao; Yaping Zhang; Liang Liu; Yu Chen; Di Wang; Xian Jin#; Chengxing Shen; Metabolomics study of the effect of smoking and high-fat diet on metabolic responses and related mechanism following myocardial infarction in mice, Life Sciences, 2020, 263：118570. DOI: 10.1016/j.lfs.2020.118570
- 01/01/2023-12/31/2026
National Natural Science Foundation of China, ¥520,000, 82271592
The Role And Mechanism Of AMFR In Regulating Mitochondrial Fission and Cardiomyocyte Senescence After Myocardial Ischemia/Reperfusion Injury
Role: Principal Investigator - 01/01/2019-12/31/2022
National Natural Science Foundation of China, ¥570,000, 81870270
Mechanism of Orphan Nuclear Receptor-Nr4a1 Regulating Monocyte /Macrophage Differentiation and Polarization in Improving Cardiac Repair After Acute Myocardial Infarction in Diabetic Mice
Role: Principal Investigator
