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ZHOU Chao  

  • Graduate Supervisor, Associate Researcher
  • Department: Orthopedics
  • Research Area: Interdisciplinary medical engineering, biomaterials
  • Research Interests: Research on bone tissue structure analysis and the design and development of chiral biomaterials, the development of natural biomaterials and the application in tissue damage repair, as well as the research on chiral detection and chiral regulation: chiral strategy for disease diagnosis and chiral strategy for disease treatment, etc.
  • Contact: zh2c0211@163.com
Biography Positions Publications Research Projects Patents
  • MD from Shanghai Institute of Microsystem, Chinese Academy of Sciences & Shanghai University of Engineering Science, Joint Program, 2015
  • PhD from Shanghai Jiao Tong University, 2021
  • Associate Researcher, Department of Orthopedics, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
  1. Chao Zhou†, Xueliang Zhang†, Jing Ai†, Ting Ji, Lu Han*, Yingying Duan*, Masaya Nagai*& Shunai Che*. Chiral hierarchical structure of bone minerals, Nano Research, 2022, 15(2): 1295-1302.https://doi.org/10.1007/s12274-021-3653-z 
  2. Chao Zhou†, Shaoyang Zhang†, Jing Ai†, Ping Li, Yanjie Zhao, Baojie Li*, Lu Han*, Yingying Duan*&Shunai Che*. Enantioselective Interaction between Cells and Chiral Hydroxyapatite Films[J]. Chemistry of Materials, 2021, 34(1): 53-62. https://doi.org/10.1021/acs.chemmater.1c02417 
  3. Chao Zhou,‡ Anqi Liu,‡ Ping Li,‡ Jing Ai, Lu Han, Shaoyang Zhang, Shuai Chen, Yuanming Ouyang*, Baojie Li*, Shunai Che* and Cunyi Fan*. Chiral mesostructured hydroxyapatite on 3D macroporous coralline scaffolds for enantio-selective osteogenesiss[J], Materials Advances, 2023, 4, 5817 - 5826. Advance Article. https://doi.org/10.1039/D3MA00773A 
  4. Mengru Li, Xiao Li, Yaowei Lv, Hede Yan, Xiang-Yang Wang, Jin He, Chao Zhou*, Yuanming Ouyang*, Chiral MoS2 @BC fibrous membranes selectively promote peripheral nerve regeneration, Journal of Nanobiotechnology, 2024, 22:337.https://doi.org/10.1186/s12951-024-02493-6
  5. Hui Wang, Ziyang Sun, Shikun Wang, Juehong Li, Zhiwen Yan, Jiacheng Hu, Shuai Chen * , Chao Zhou* , Cunyi Fan*. Chiral Arginine Modified Electrospun Membrane for Enhancing Tendon Healing. Advanced Functional Materials, 2024, 2402845.https://doi.org/10.1002/adfm.202402845
  6. Zhuochang Cai, Cheng Qu, Wei Song, Haoyuan Wang, Shuai Chen,* Chao Zhou,* and Cunyi Fan*. Hierarchical Chiral Calcium Silicate Hydrate Films Promote Vascularization for Tendon‐to‐Bone Healing[J]. Advanced Materials, 2024: 2404842.https://doi.org/10.1002/adma.202404842
  7. Liang Yang, Jinzhou Du, Shengyang Jin, Shuyi Yang, Zhaowei Chen, Shiyang Yu, Cunyi Fan,* Chao Zhou,* and Hongjiang Ruan*, Chirality-Induced Hydroxyapatite Manipulates Enantioselective Bone-Implant Interactions Toward Ameliorative Osteoporotic Osseointegration, Advanced Science, 2024, 2411602. https://doi.org/10.1002/advs.202411602 
  8. Tengfei Lou, Xu Wang, Juehong Li, Wei Wang, Pei Han, Shiyang Yu,* Cunyi Fan,* Chao Zhou,* and Hongjiang Ruan*, Chirality Regulates Bone Regeneration through Mechanoresponse and Immunoregulation, ACS Nano 2025, 19, 8, 7767–7783.https://doi.org/10.1021/acsnano.4c13164 
  9. Gang Luo , Juehong Li, Shuai Chen, Zhengqiang Yuan, Ziyang Sun, Tengfei Lou, Zhenyu Chen, Hang Liu , Chao Zhou* , Cunyi Fan* , Hongjiang Ruan*. Polylactic Acid Electrospun Membranes Coated with Chiral Hierarchical-structured Hydroxyapatite Promote Tendon Healing Based on a Macrophage-Homeostatic Modulation Strategy. Bioactive Materials 47 (2025) 460–480. https://doi.org/10.1016/j.bioactmat.2025.01.027
  10. Chao Zhou*, Yongfeng Ji, Wanjun Liu, Shunai Che*, Cunyi Fan*. Chiral biology: An unusual perspective on chirality-induced cell behaviors and life phenomenon. The Innovation Life 2025, 3:100138. https://doi.org/10.59717/j.xinn-life.2025.100138
  • 01/01/2025-12/31/2027
    National Natural Science Foundation of China, ¥300000, 82402770
    Role: Project leader
  1. [Che Shun'ai; Zhou Chao] (2023), “A Preparation Method and Application of a Chiral Mesoscopic Structure Hydroxyapatite Film”, ZL 202111338162.2 
  2. [Fan Cunyi; Zhou Chao; Che Shun'ai; Liu Shen; Xu Binbin] (2024), “A Chiral Multi-level Structure Bioceramic Material and Its Preparation Method ”,ZL2022 1 0171578.8                                                
  3. [Fan Cunyi, Zhou Chao, Xu Binbin, Yang Ai, Li Jie] (2025), “A multi-functional bone hardness testing fixture”, ZL 202422550550.2         

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