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ZHANG Xiaojie
- Graduate Supervisor, Associate Chief Physician
- Department: Neurology
- Research Area: Neurodegeneration Diseases
- Research Interests: Transcranial Ultrasound Stimulation and Transcranial Magnetic Stimulation
- Contact: xjzzhang@sjtu.edu.cn
- Fellowship, National Institutes of Health, NIA, the United States, 2024
- Associate Chief Physician, Department of Neurology, Shanghai Sixth People's Hospital, 2022
- Attending Physician, Department of Neurology, Shanghai Sixth People's Hospital, 2016
- Resident, Department of Neurology, Shanghai Sixth People's Hospital, 2014
- PhD from Shanghai Jiao Tong University School of Medicine, 2014
- Assistant Researcher of Neuroscience, Shanghai Institutes for Biological Sciences, CAS, 2008
- MD from Shanghai Jiaotong University School of Medicine, 2008
- BS from Taishan Medical College, 2005
- Associate Chief Physician, Department of Neurology, Shanghai Sixth People's Hospital
- Xu XJ, Zhou QM, Zhang XJ, Li TB, Niu L, Xu GW, Chen S, Shao YP, Le WD. Untargeted metabolomics based on LC-MS and GC-MS reveal metabolic reprogramming and putative biomarkers in amyotrophic lateral sclerosis. Chin Med J (Engl). 2025, Online ahead of print. DOI： 10.1097/CM9.0000000000003874
- Zheng WS*, Zhang XJ*, Chen JJ, Luan XH, Wang JJ, Zhang LR, Liu K, Zhao YW, Xu ZW. The effect of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex on the Amyotrophic Lateral Sclerosis patients with cognitive impairment: a double-blinded, randomized, and sham control trial. CNS Neurosci. Ther. 2025, 31(3):e70316. DOI： 10.1111/cns.70316
- Zhang XJ, Zhang H, Dong J, Cai HB, Le WD. Advances in autophagy for Parkinson’s disease pathogenesis and treatment. (Aging and Neurodegenerative Diseases) Ageing Neur Dis. 2025;5:6. DOI： 10.20517/and.2024.33
- Liu ZH, Zhang H, Lu KL, Chen L, Zhang YQ, Xu ZW, Zhou HS, Sun JF, Xu MY, Ouyang Q, Cao L, Zhao YW, Jiang LX, Zheng YY, Zhang XJ#. Low-intensity pulsed ultrasound modulates disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Cell Reports, 2024, 24;43(9):114660. DOI: 10.1016/j.celrep.2024.114660
- Zhong CY, Guo N, Hu CF, Ni RL, Zhang XJ, Meng ZY, Liu TT, Ding SQ, Ding WH, Zhao YW, Cao L, Zheng YY. Efficacy of Wearable low-intensity pulsed Ultrasound treatment in the Movement disorder in Parkinson's disease (the SWUMP trial): protocol for a single-site, double-blind, randomized controlled trial. Trails, 2024, 25(1):275. DOI: 10.1186/s13063-024-08092-y
- Liu ZH, Li J, Bian Y, Zhang XJ#, Cai XJ#, Zheng YY#. Low-intensity pulsed ultrasound reduced lymphedema by regulating macrophage polarization and enhancing microcirculation. Frontiers in Bioengineering and Biotechnology. 2023, 5(11): 1173169. DOI: 10.3389/fbioe.2023.1173169
- Zhang XJ*, Chen S*, Lu KL, Wang F, Deng JS, Xu ZW, Wang XZ, Zhou QM, Le WD#, Zhao YW#. Verapamil ameliorates motor neuron degeneration and improves lifespan in the SOD1G93A mouse model of ALS by enhancing autophagic flux. Aging and Disease, 2019. 10(6): 1159-1173. DOI: 10.14336/AD.2019.0228
- Lu KL, Liu L, Xu XF, Zhao F, Deng JS, Tang X, Wang XZ, Zhao BQ, Zhang XJ#, Zhao YW#. ADAMTS13 ameliorates inflammatory responses in experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 2020, 17(1):67. DOI: 10.1186/s12974-020-1713-z
- 01/01/2023-12/31/2025
Interdisciplinary Program of Shanghai Jiao Tong University (YG2023QNB18), ¥250,000
The role of low-intensity ultrasound in a mouse model of Amyotrophic lateral sclerosis
Role: Principal Investigator - 12/01/2023-11/30/2026
Key Project of Shanghai Municipal Commission of Science and Technology (23Y11900800), ¥300,000
A clinical trial of low-intensity ultrasound in Amyotrophic lateral sclerosis
Role: Principal Investigator - 12/01/2025-11/30/2027
Shanghai Pujiang Talent Program (25PJD098), ¥300,000
Low-Intensity transcranial ultrasound ameliorates neuronal hyperexcitability in ALS
Role: Principal Investigator
- [Xiaojie Zhang, et al] (2022), “Ultrasound to treat amyotrophic lateral sclerosis in the animal model" No. ZL 202211550779.5
