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LI Qing
- Graduate Supervisor, Associate Researcher
- Department: Orthopedics
- Research Area: Regenerative Medicine
- Research Interests: The Role of Stem Cell-Derived Extracellular Vesicles in Tissue Regeneration and Aging-Related Degenerative Diseases
- Contact: liqing_236@sjtu.edu.cn
- Associate Researcher, Institute of Microsurgery on Extremities, Department of Orthopedics, Shanghai Sixth People’s Hospital, 2021
- Postdoctoral fellow from Institutes for Biological Sciences, Chinese Academy of Sciences, 2013
- PhD from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2010
- Committee member, Chinese Society for Extracellular Vesicles, Chinese Research Hospital Association
- Lei Luo, Zhengsheng Chen, Ji Yuan, Xin Niu, Jiashuo Liu, Chao Gu, Hong Xu, Chuncui Jia, Tao Na, Shufang Meng, Yang Wang*, Haiyan Li*, Qing Li*. Identification of a specific marker panel for human mesenchymal stem cell-derived small extracellular vesicles. Interdisciplinary Medicine，2025 3(6):
e70065. https://doi.org/10.1002/inmd.70065 - Lei Luo,Yuhang Du,Xin Niu,Jiashuo Liu,Ji Yuan, Hong Xu,Yang Wang*, Haiyan Li*, Qing Li*. Optimized Tangential Flow Filtration for Efficient Isolation of Highly Pure and Bioactive sEVs. Analytical Chemistry, 2025 97(31):17261-17274. doi: 10.1021/acs.analchem.5c03781
- Yu Chen, Rongrong Cao, Zhengsheng Chen, Juntao Zhang, Yajing Ren, Xin Niu, Ji Yuan, Lei Luo, Shuxiang Yu, Yang Wang*, Qing Li*. iPSCs derived sEVs ameliorate NK cell senescence by targeting CISH-STAT3. Stem Cell Research & Therapy, 2025 16(1):634. doi: 10.1186/s13287-025-04761-0.
- Feng, K, Liu, J, Gong, L, Ye, T, Chen, Z, Wang, Y*, Li, Q*, and Xie, X* (2025). Engineered MSC-sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis. Adv Sci (Weinh), 2025 Jan 4:e2413759. doi: 10.1002/advs.202413759
- Feng, K#, Ye, T#, Xie, X#, Liu, J, Gong, L, Chen, Z, Zhang, J, Li, H, Li, Q*, and Wang, Y*. ESC-sEVs alleviate non-early-stage osteoarthritis progression by rejuvenating senescent chondrocytes via FOXO1A-autophagy axis but not inducing apoptosis. Pharmacol Res., 2024 Nov:209:107474.
- Chen Z#; Luo L#; Ye T#; Zhou J; Niu X; Yuan J; Yuan T; Fu D; Li H; Li Q*; Wang Y*; Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles, J Extracell Vesicles., 2024;13(2)
- Gong L, Chen Z, Feng K, Luo L, Zhang J, Yuan J, Ren Y, Wang Y*, Zheng X*, Li Q*. A versatile engineered extracellular vesicle platform simultaneously targeting and eliminating senescent stromal cells and tumor cells to promote tumor regression. J Nanobiotechnology. 2024;22(1):105
- Teng Ye#, Zhengsheng Chen#, Jieyuan Zhang#, Lei Luo, Renzhi Gao, Liangzhi Gong, Yuhang Du, Zongping Xie*, Bizeng Zhao*, Qing Li*, Yang Wang. Large extracellular vesicles secreted by human iPSC-derived MSCs ameliorate tendinopathy via regulating macrophage heterogeneity. Bioactive materials, 2022 Aug 26;21:194-208. doi: 10.1016/j.bioactmat.2022.08.007.
- Qing Li, Xinyu Niu, Yan Yi, Yu Chen, Ji Yuan, Juntao Zhang, Haiyan Li, Yuguo Xia, Yang Wang, Zhifeng Deng. Inducible Pluripotent Stem Cell-Derived Small Extracellular Vesicles Rejuvenate Senescent Blood-Brain Barrier to Protect against Ischemic Stroke in Aged Mice. ACS Nano. 2023 Jan 10;17(1):775-789. doi: 10.1021/acsnano.2c10824
- 01/01/2026-12/31/2029
National Natural Science Foundation of China, ¥490000, 82572866
Traumatic Brain Tissue-Derived Extracellular Vesicles Accelerated Fracture Healing via the Tead1-Glycolysis-H3K9-Regulated Endochondral Ossification
Role: Principal Investigator - 11/01/2024-11/30/2027
National Key Research and Development Project, ¥17,000,000, 2024YFA1107300
Research on Innovative Drug Development and Regulatory Evaluation Technology for Stem Cells and Their Derivatives
Role: Core Researcher
