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Research

LUAN Xinghua  

  • Graduate Supervisor, Associate Chief Physician
  • Department: Neurology
  • Research Area: Neuromuscular disorders and Neuropathology
  • Research Interests: Charcot-Marie-Tooth Disease, Small fiber neuropathy, NIID
  • Contact: green_lxh@sina.com
Biography Positions Publications Research Projects
  • Jan 2023–Present  
    Associate Chief Physician, Department of Neurology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine
  • Aug 2020–Dec 2022  
    Attending Physician, Department of Neurology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine
  • Aug 2016–Aug 2020  
    Attending Physician, Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
  • Mar 2016–Feb 2017  
    Visiting Scholar, Neuromuscular Division, Department of Neurology, The Johns Hopkins Hospital, USA
  • Aug 2012–Jul 2016  
    Resident Physician, Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
  • Sep 2005–Jul 2010
    PhD from Department of Neurology, Peking University First Hospital
    Supervisor: Prof. Yun Yuan
  • Nov 2008–Oct 2009
    Research Exchange, Institute of Molecular Neuroscience, Faculty of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Host Supervisor: Prof. Hisashi Mori
  • Sep 2000–Jul 2005
    Bachelor of Medicine from China Medical University
  • Deputy Group Leader, Neuromuscular and Electrophysiology Group, Neurology Branch, Shanghai Medical Association 
  1. Yuwen Cao, Jingying Wu, Yunhua Yue, Chao Zhang, Shihua Liu, Ping Zhong, Shige Wang, Xiaojun Huang, Weiping Deng, Jing Pan, Lan Zheng, Qing Liu, Liang Shang, Benyan Zhang, Jie Yang, Guang Chen, Shufen Chen, Li Cao*, Xinghua Luan*. Expanding the clinical spectrum of adult-onset neuronal intranuclear inclusion disease. Acta Neurol Belg. 2022 Jun;122(3):647-658. 
  2. Yuwen Cao, Wotu Tian , Jingying Wu , Xingwang Song , Li Cao*, Xinghua Luan*. DNA hypermethylation of NOTCH2NLC in neuronal intranuclear inclusion disease: a case–control study. J Neurol . 2022 Nov;269(11):6049-6057.
  3. Jingying Wu, Taotao Liu, Benyan Zhang, Chang Liu, Xinghua Luan*, Li Cao*.An AARS1 variant identified to cause adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia.Transl Neurodegener. 2023 Apr 28;12(1):19. 
  4. Feixia Zhan, Wotu Tian, Yuwen Cao, Jingying Wu, Ruilong Ni, Taotao Liu, Yun Yuan, Xinghua Luan*, and Li Cao*.Episodic Neurological Dysfunction in X-Linked Charcot-Marie-Tooth Disease: Expansion of the Phenotypic and Genetic Spectrum.J Clin Neurol. 2024 Jan;20(1):59-66.
  5. Xiaolin Bai, Jingyan Xiang, Jiangshan Deng, Wan Hai Ding, Xinghua Luan*, Zhi Geng*. Clinical Reasoning: A 30-Year-Old Woman Presenting With Rapidly Progressive Dementia and Extreme Hypoglycorrhachia. Neurology. 2024 Mar 12;102(5):e209188.
  6. Jingying Wu, Xin Cheng, Duxin Ji, Huiwen Niu, Songquan Yao, Xukun Lv, Jianqiang Wang, Ziyi Li, Haoran Zheng, Yuwen Cao, Fei-xia Zhan, Mengyuan Zhang, Wotu Tian, Xiaojun Huang*, Xinghua Luan*, Li Cao*. The Phenotypic and Genotypic Spectrum of CSF1R-Related Disorder in China.Mov Disord. 2024 May;39(5):798-813.
  7. Zhu X, Zhan F, Shen X, Jiang W, Cao L, Luan X*. A Charcot-Marie-Tooth Disease Type 1J Case With Diffuse Thickening of Peripheral Nerves. Neurology. 2025 Feb 25;104(4):e213359.
  8. Lu J#, Jia M, Luan X#, Zhang Z, Wu J, Huang X,Yang L, Zhao X, Zhou M, Fu Y, Yang Q, Zhang J,Cao L and Guo C. Case Report: A pharmacist-led precision therapy framework for managing invasive fungal infection in CSF1R-Related leukoencephalopathy post Allo-HSCT. Front Pharmacol. 2025 Nov 27:16:1656503.
  9. 朱啸巍,钟平,栾兴华*.外周组织活检病理在帕金森病诊断中的应用[J].中国实用神经疾病杂志,2022,25(02):250-254. 
  10. 曹煜雯，曹立，栾兴华*.皮肤活组织检查在神经系统疾病诊断中的应用. 中华神经科杂志, 2020,53(10) : 839-84.
  • Oct 2024 – Sep 2027
    Shanghai Natural Science Foundation, General Program，¥200,000
    Mechanistic Study on Pathogenesis of NOTCH2NLC Gene Forming Intranuclear Inclusions via Phase Separation and Inducing RNA Aggregation  
    Role: Principal Investigator
  • Oct 2022 – Sep 2025 
    Basic Research Cultivation Program (General), Shanghai Sixth People's Hospital,  ¥ 300,000
    Role of NMNAT2-SARM1-NAD+ Pathway in Peripheral Nerve Axonal Degeneration in NIID  
    Role: Principal Investigator
  • Jul 2021 – Jul 20243. 
    Industry-Academia Collaborative Research Project, ¥ 500,000
    An Exploratory Study on Intraepidermal Nerve Fiber Density Changes in CIPN Patients  
    Role: Principal Investigator
  • Jan 2018 – Dec 2020 
    Ruijin Hospital "Guangci Excellence Young Scholars Training Program" (GCQN-2017-A03), ¥ 50,000 
    Establishment of Neuromuscular Disease Specimen Biobank  
    Role: Principal Investigator
  • Jan 2013 – Dec 2015 
    National Natural Science Foundation of China (NSFC), Young Scientists Fund (81200965), ¥ 230,000
    Expression of Connexin-32 in Human Vascular Endothelial Cells and Its Vascular Pathogenic Mechanisms  
    Role: Principal Investigator
  • Jan 2012 – Dec 2014
    Shanghai Young College Teachers Training Funding Program, ¥ 50,000  
    Clinical, Pathological and Genetic Characteristics of Neutral Lipid Storage Disease with Myopathy  
    Role: Principal Investigator
  • Jan 2012 – Dec 2013
    Ministry of Education New Teacher Foundation, China (20110073120088), ¥ 50,000 
    Expression of Connexin-32 in Human Vascular Endothelial Cells and Vascular Pathogenic Mechanisms in CMTX1  
    Role: Principal Investigator

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