Research
Search
Close
ZHANG Yi
- Graduate Supervisor, Associate Professor
- Department: Endocrinology and Metabolism
- Research Area: Neural Regulation of Glucose and Lipid Metabolism
- Research Interests: Pathogenesis of obesity and diabetes
- Contact: yi.zhang@sjtu.edu.cn
- Jan. 2025 - Present
Assistant Researcher, Diabetes Institute, Shanghai Sixth People's Hospital - Apr. 2024 - Jan. 2025
Assistant Researcher, Diabetes Institute, Shanghai Sixth People's Hospital - Jan. 2021 - Apr. 2024
Postdoctoral Researcher, Diabetes Institute, Shanghai Sixth People's Hospital - Sep. 2015 - Dec. 2020
Ph.D. in Nutrition and Food Hygiene, Huazhong University of Science and Technology - Sep. 2010 - Jul. 2015
Bachelor of Preventive Medicine, Beihua University
- Zhang Y#, Guan Y, Pan S, Yan L, Wang P, Chen Z, Shen Q, Zhao F, Zhang X, Li J, Li J, Cai D, Zhang G; Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders, Proceedings of the National Academy of Sciences of the United States of America, 2020, 117(33): 20149-20158
- Zhang Y#, Zhu Y, Wang J, Jin L, Guo M, Chen L, Zhang L, Li Y, Wan B, Zhang R, Jia W, Hu C; Neuregulin4 Acts on Hypothalamic ErBb4 to Excite Oxytocin Neurons and Preserve Metabolic Homeostasis, Advanced Science, 2023, 10(6) （第一作者, IF=15.2）
- Zhang Y#, Chen L, Xuan Y, Zhang L, Tian W, Zhu Y, Wang J, Wang X, Qiu J, Yu J, Tang M, He Z, Zhang H, Chen S, Shen Y, Wang S, Zhang R, Xu L, Ma X, Liao Y, Hu C; Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders, Cell Reports, 2024, 43(3)
- Chen Z, Wan B, Zhang H, Zhang L, Zhang R, Li L, Zhang Y*, Hu C. Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance. Nat Commun. 2024 Nov 22;15(1):10111.
- Wan, B., Zhang, L., Wang, X., Zhang, R., Li, L., Zhang, Y*., Chen, Z., & Hu, C. (2025). Fam172a Mediates the Stimulation of Hypothalamic Oxytocin Neurons to Suppress Obesity-Induced Anxiety. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 12(14), e2414723.
- Chen L, Xuan Y, Zhu Y, Wang J, Tian W, Yang X, Chen W, Chen S, Wang S, Miao Q, Liu Y, Zhang R, Hu C, Zhang Y*, Jin L, Yu H. Adipocyte secreted NRG4 ameliorates age-associated metabolic dysfunction. Biochem Pharmacol. 0 Jul;225:116327.
- Wang, X., Xiong, X., Xuan, Y., Tian, W., Chen, L., Chen, Z., Zhang, Y*., Shen, W. L., & Hu, C. (2025). Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice. Molecular biomedicine, 6(1), 75. https://doi.org/10.1186/s43556-025-00324-0
- 01/01/2025-12/31/2028
National Natural Science Foundation of China (General Program), ¥480,000, 82470818
Tfrc-Mediated Iron Homeostasis in Hypothalamic POMC Neuron Development and Energy Balance
Role: Principal Investigator - 01/01/2022-12/31/2024
National Natural Science Foundation of China (Young Scientists Fund, Category C), ¥300,000, 82100908
Role of Hypothalamic TfR1-Mediated Iron Metabolism in Obesity Progression
Role: Principal Investigator - 12/01/2024-11/30/2027
Shanghai Science and Technology Commission (Rising-Star Program, Category A), ¥400,000, 24QA2706700
Role and Mechanism of POMC Neuronal Iron Deficiency in Early-Onset Obesity
Role: Principal Investigator
