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JIA Wei  

  • Doctoral Supervisor, Professor
  • Department: Translational Medicine Center
  • Research Area: Internal Medicine (Endocrinology and Metabolism)
  • Research Interests: Microbial metabolism and host-gut microbe interactions in the development of gastrointestinal diseases and metabolic disorders
  • Contact: wjia4226@hotmail.com
Biography Positions Publications Research Projects Patents
  • Adjunct Professor and Director,  Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Center for Translational Medicine, 2012-present
  • Chair Professor, University of Hong Kong Department of Pharmacology & Pharmacy, 2024-present
  • Cheung On Tak Endowed Chair Professor and Acting Dean,  Hong Kong Baptist University School of Chinese Medicine, 2019-2024
  • Professor, University of Hawaii at Manoa University of Hawaii Cancer Center, 2013-2019
  • Professor, University of North Carolina at Greensboro Department of Nutrition, 2008-2013
  • Adjunct Professor and Director, Shanghai University of Chinese Medicine, 2007-2012 
  • Principle Investigator, Shanghai Jiao Tong University Shanghai Center for Systems Biomedicine, 2005-2008
  • Professor and Associate Dean for Research, Shanghai Jiao Tong University School of Pharmacy, 2003-2008
  • Professor and Executive Vice Dean, Tianjin University College of Pharmaceutical Science and Biotechnology, 2001-2002
  • PhD from University of Missouri (USA), 1996
  • MS from University of Missouri (USA), 1991
  • BS from Jiangnan University, 1986
  • Director, Center for Translational Medicine, Shanghai Sixth People's Hospital
  1. Mingliang Zhao, Zhenxing Ren, Aihua Zhao, Yajun Tang, Junliang Kuang, Mengci Li, Tianlu Chen, Shouli Wang, Jieyi Wang, Huiheng Zhang, Jijun Wang, Tianhong Zhang, Jiahui Zeng, Xiaohua Liu, Guoxiang Xie, Penghong Liu, Ning Sun, Tianhao Bao, Tongtong Nie, Jingchao Lin, Ping Liu, Yuanyi Zheng, Xiaojiao Zheng*, Tiemin Liu*, Wei Jia*. Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity. Cell Metabolism. accepted
  2. Tianlu Chen, Lu Wang, Guoxiang Xie, Bruce S. Kristal, Xiaojiao Zheng, Tao Sun, Matthias Arnold, Gregory Louie, Mengci Li, Lirong Wu, Siamac Mahmoudiandehkordi, Matthew J. Sniatynski, Kamil Borkowski, Qihao Guo, Junliang Kuang, Jieyi Wang, Kwangsik Nho, Zhenxing Ren, Alexandra Kueider-Paisley, Colette Blach, Rima Kaddurah-Daouk*, Wei Jia*. For the Alzheimer’s disease neuroimaging initiative and the Alzheimer disease metabolomics consortium, serum bile acids improve prediction of Alzheimer’s progression in a sex-dependent manner. Advanced Science. accepted
  3. Tianlu Chen#, Fengfeng Pan#, Qi Huang#, Guoxiang Xie, Xiaowen Chao, Lirong Wu, Jie Wang, Liang Cui, Tao Sun, Mengci Li, Ying Wang, Yihui Guan, Xiaojiao Zheng, Zhenxing Ren, Yuhuai Guo, Lu Wang, Kejun Zhou, Aihua Zhao, Fang Xie*, Qihao Guo*, Wei Jia*. Metabolic dysregulation in Alzheimer’s disease: emerging role of ammonia abnormality. Nature Communications. accepted
  4. Zhenxing Ren#, Ling Zhao#, Mingliang Zhao, Tianhao Bao, Tianlu Chen, Aihua Zhao, Xiaojiao Zheng, Xinru Gu, Tao Sun, Yuhuai Guo, Guoxiang Xie, Yajun Tang, Wei Jia*. Increased intestinal bile acid absorption contributes to age-related cognitive impairment. Cell Report Medicine. accepted
  5. Junliang Kuang, Jieyi Wang, Yitao Li, Mengci Li, Mingliang Zhao, Kun Ge, Dan Zheng, Kenneth C.P. Cheung, Boya Liao, Shouli Wang, Tianlu Chen, Yinan Zhang, Congrong Wang, Guang Ji, Peng Chen, Hongwei Zhou, Cen Xie, Aihua Zhao, Weiping Jia*, Xiaojiao Zheng*, Wei Jia*. Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis. Cell Metabolism. 2023. 35(10):1752-1766.e8. 
  6. Yinghong Zhu#, Xingxing Jian#, Shuping Chen, Gang An, Duanfeng Jiang, Qin Yang, Jingyu Zhang, Jian Hu, Yi Qiu, Xiangling Feng, Jiaojiao Guo, Xun Chen, Zhengjiang Li, Ruiqi Zhou, Cong Hu, Nihan He, Fangming Shi, Siqing Huang, Hong Liu, Xin Li, Lu Xie, Yan Zhu, Lia Zhao, Yichuan Jiang, Jian Li, Jinuo Wang, Lugui Qiu, Xiang Chen*, Wei Jia*, Yanjuan He*, Wen Zhou*. Targeting gut microbial nitrogen recycling and cellular uptake of ammonium to improve bortezomib resistance in multiple myeloma. Cell Metabolism. 2023. 36(1):159-175.e8.
  7. Lixiang Zhai#, Haitao Xiao#, Chengyuan Lin#, Hoi Leong Xavier Wong#, Yan Y Lam#, Mengxue Gong, Guojun Wu, Ziwan Ning, Chunhua Huang, Yijing Zhang, Chao Yang, Jingyuan Luo, Lu Zhang, Ling Zhao, Chenhong Zhang, Johnson Yiu-Nam Lau, Aiping Lu, Lok-Ting Lau, Wei Jia*, Liping Zhao*, Zhao-Xiang Bian*. Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome. Nature Communications. 2023. 14(1):4986. 
  8. Mengci Li, Shouli Wang, Yitao Li, Mingliang Zhao, Junliang Kuang, Dandan Liang, Jieyi Wang, Cynthia Rajani, Xinran Ma, Yajun Tang, Zhenxing Ren, Tianlu Chen, Aihua Zhao, Cheng Hu, Chengxing Shen, Ping Liu, Xiaojiao Zheng*, Wei Jia*. Gut microbiota - bile acid crosstalk contributes to the rebound weight gain in individuals after calorie restriction. Nature Communications. 2022. 13(1):2060.
  9. Shouli Wang, Junliang Kuang, Hongwei Zhang, Wenlian Chen, Xiaojiao Zheng, Jieyi Wang, Fengjie Huang, Kun Ge, Mengci Li, Mingliang Zhao, Cynthia Rajani, Jinshui Zhu, Aihua Zhao*, Wei Jia*. Bile acid-microbiome interaction promotes gastric carcinogenesis. Advanced Science. 2022. 9(16):e2200263. 
  10. Xiaojiao Zheng#, Tianlu Chen#, Runqiu Jiang#, Aihua Zhao#, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia*, Changtao Jiang*, Wei Jia*. Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism. Cell Metabolism. 2021. 33(4):791-806. 
  11. Xiaojiao Zheng#, Tianlu Chen#, Aihua Zhao#, Zhangchi Ning#, Junliang Kuang, Shouli Wang, Yijun You, Yuqian Bao, Xiaojing Ma, Haoyong Yu, Jian Zhou, Miao Jiang, Mengci Li, Jieyi Wang, Xiaohui Ma, Shuiping Zhou, Yitao Li, Kun Ge, Cynthia Rajani, Guoxiang Xie, Cheng Hu, Yike Guo, Aiping Lu*, Weiping Jia*, Wei Jia*. Hyocholic acid species as novel biomarkers for metabolic disorders. Nature Communications. 2021. 12(1):1487.
  12. Wei Jia*, Meilin Wei, Cynthia Rajani, Xiaojiao Zheng*. Targeting the alternative bile acid synthetic pathway for metabolic diseases. Protein & Cell. 2021. 12(5):411-425.
  13. Wei Jia*, Cynthia Rajani, Hongxi Xu, Xiaojiao Zheng*. Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma. Protein & Cell. 2021. 12(5):374-393.
  14. Fengjie Huang, Xiaojiao Zheng, Xiaohui Ma, Runqiu Jiang, Wangyi Zhou, Shuiping Zhou, Yunjing Zhang, Sha Lei, Shouli Wang, Junliang Kuang, Xiaolong Han, Meilin Wei, Yijun You, Mengci Li, Yitao Li, Dandan Liang, Jiajian Liu, Tianlu Chen, Chao Yan, Runmin Wei, Cynthia Rajani, Chengxing Shen, Guoxiang Xie, Zhaoxiang Bian, Houkai Li*, Aihua Zhao*, Wei Jia*. Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism. Nature Communications. 2019. 10(1): 4971.
  15. Wei Jia*, Guoxiang Xie, Weiping Jia. Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nature Reviews Gastroenterology & Hepatology. 2018. 15(2):111-128. 
  16. Linjing Zhao#, Yan Ni#, Mingming Su#, Hongsen Li, Fangcong Dong, Wenlian Chen, Runmin Wei, Lulu Zhang, Seu Ping Guiraud, Francois-Pierre Martin, Cynthia Rajani, Guoxiang Xie, Wei Jia*. High throughput and quantitative measurement of microbial metabolome by gas. Analytical Chemistry. 2017. 89(10):5565-5577.
  17. Xiaojiao Zheng, Fengjie Huang, Aihua Zhao, Sha Lei, Yunjing Zhang, Guoxiang Xie, Tianlu Chen, Chun Qu, Cynthia Rajani, Bing Dong, Defa Li, Wei Jia*, Bile acid is a significant host factor shaping the gut microbiome of diet-induced obese mice. BMC Biology. 2017. 15(1):120. 
  18. Wenlian Chen#, Yueying Wang#, Aihua Zhao#, Li Xia, Guoxiang Xie, Mingming Su, Linjing Zhao, Jiajian Liu, Chun Qu, Runmin Wei, Cynthia Rajani, Yan Ni, Zhen Cheng, Zhu Chen, Saijuan Chen*, Wei Jia*.  Enhanced fructose utilization mediated by SLC2A5 is a unique metabolic feature of acute myeloid leukemia with therapeutic potential. Cancer Cell. 2016. 30(5):779-791.
  19. Wenlian Chen#, Jinghan Wang#, Aihua Zhao#, Xin Xu#, Yihuang Wang#, Tianlu Chen, Junmin Li, Jianqing Mi, Yongmei Zhu, Yuanfang Liu, Yueying Wang, Jie Jin, He Huang, Depei Wu, Yan Li, Xiaojing Yan, Jinsong Yan, Jianyong Li, Shuai Wang, Xiaojun Huang, Bingshun Wang, Zhu Chen, Saijuan Chen, Wei Jia*. A distinct glucose metabolism signature of AML with prognostic value. Blood. 2014. 124(10):1645-54.
  20. J Yang, T Chen, L Sun, Z Zhao, X Qi, K Zhou, Y Cao, X Wang, Y Qiu, M Su, A Zhao, P Wang, P Yang, J Wu, G Feng, L He, W Jia, C Wan. Potential metabolite markers of schizophrenia. Molecular Psychiatry. 2013. 18(1):67-78. 
  21. Xiaojiao Zheng#, Aihua Zhao#*, Guoxiang Xie, Yi Chi, Linjing Zhao, Houkai Li, Congrong Wang, Yuqian Bao, Weiping Jia, Micheal Luther, Mingming Su, Jeremy K Nicholson, Wei Jia*. Melamine-induced renal toxicity is mediated by gut microbiota. Science Translational Medicine. 2013. 5(172): 172ra22.
  22. Jianghan Wang#, Wenlian Chen#, Junmin Li, Songfang Wu, Tianlu Chen, Yongmei Zhu, Weina Zhang, Yang Li, Yunping Qiu, Aihua Zhao, Jianqing Mi, Jie Jin, Yungui Wang, Qiuling Ma, He Huang, Depei Wu, Qinrong Wang, Yan Li, Xiaojing Yan, Jinsong Yan, Jianyong Li, Shuai Wang, Xiaojun Huang, Bingshun Wang, Wei Jia*, Yang Shen*, Zhu Chen*, Saijuan Chen*. Prognostic Significance of 2-Hydroxyglutarate Levels in Acute Myeloid Leukemia in China. Proceedings of the national academy of sciences of the United States of America. 2013. 110(42):17017-22.
  23. Xiaojiao Zheng, Guoxiang Xie, Aihua Zhao, Linjing Zhao, Chun Yao, Norman H L Chiu, Zhanxiang Zhou, Yuqian Bao, Weiping Jia*, Jeremy K Nicholson, Wei Jia*. The footprints of gut microbial-mammalian co-metabolism. 2011. 10(12):5512-22. 
  24. Wei Jia*, Houkai Li, Liping Zhao, Jeremy K Nicholson. Gut microbiota: a potential new territory for drug targeting. Nature Reviews | Drug Discovery. 2008. 7(2):123-9.
  • 01/01/2023-12/31/2026        
    National Natural Science Foundation of China, ￥520,000, 81974073
    Hyodeoxycholic acid regulates hepatic lipid metabolism through Parabacteroides distasonis – succinate- hepatic CYP7B1 signaling. 
    Role: Principal Investigator
  • 01/01/2020-12/31/2023        
    National Natural Science Foundation of China, ￥550,000, 82270917
    Hyodeoxycholic acid regulates hepatic lipid metabolism through Parabacteroides distasonis – succinate- hepatic CYP7B1 signaling. 
    Role: Principal Investigator
  • 12/01/2021-11/30/2026
    National Key Research and Development Project, ¥4,000,000, 2021YFA1301303
    Discovery of targets of microbiota-host co-metabolism signaling molecules and pathways
    Role: Project leader
  • 12/01/2022-11/30/2027
    National Key Research and Development Project, ¥2,970,000, 2022YFA080640
    Dynamic changes in the gut microbial composition and metabolites in different physiological/pathological states
    Role: Project leader
  1. Bile acid derivative, composition and application thereof. Wei Jia, Guoxiang Xie, Ning Zhai, Aihua Zhao, Xiaojiao Zheng. State Intellectual Property Office of the People’s Republic of China, patent issued on July 18, 2023. ZL 202010658243.X 
  2. Metabolic markers and kits for detecting emotional disorders and methods of use. Wei Jia, Guoxiang Xie. State Intellectual Property Office of the People’s Republic of China, patent issued on July 18, 2023. ZL 201910875185.3 
  3. Diagnostic device and computer system for detecting non-alcoholic fatty liver disease status in human subjects, Wei Jia, Guoxiang Xie, Tianlu Chen, and Kejun Zhou. State Intellectual Property Office of the People’s Republic of China, patent issued on Mar 7, 2023. ZL 202110323130.9 
  4. Fructose analogs and their combinations as anti-cancer agents, Wei Jia, Wenlian Che, Aihua Zhao, and Guoxiang Xie. State Intellectual Property Office of the People’s Republic of China, patent issued on Jan 13, 2023. ZL 201710232867.3 
  5. Bile acid derivative, composition and application thereof. Wei Jia, Guoxiang Xie, Ning Zhai, Aihua Zhao, Xiaojiao Zheng. US Patent App. 17/637,450, Sept 1, 2022 
  6. A non-invasive saliva detection method for 1,5-anhydroglucitol and its application. Yuqian Bao, Wei Jia, Aihua Zhao, Jian Zhou, Xiaojing Ma, Yufei Wang, Chaohui Jian. State Intellectual Property Office of the People’s Republic of China, patent issued on Sept 27, 2022. ZL 201911207125.0 
  7. Quantitative detection method of multiple metabolites in biological sample and metabolite array technology. Wei Jia, Guoxiang Xie, and Lu Wang. US Patent App. 17/309,062, Jan 27, 2022 
  8. Metabolite markers and methods relating to the risk assessment of cardiovascular diseases, Wei Jia, Guoxiang Xie, and Zhilong Lin, State Intellectual Property Office of the People’s Republic of China, patent issued on Aug 29, 2022, ZL 202110000655.9. 
  9. Application of betaine, Wen Zhou, Jingyu Zhang, Wei Jia, Jiliang Xia. State Intellectual Property Office of the People’s Republic of China, patent issued on May 10, 2022, ZL 202111006835.4. 
  10. Metabolic biomarkers for the identification and characterization of Alzheimer’s Disease. Wei Jia, et al. US patent No. US 2021/0293794 A1. Sept 23, 2021 
  11. Blood metabolite markers and applications in diagnosing multiple myeloma. Wen Zhou, Wei Jia, Jiliang Xia, Jingyu Zhang, Xuan Wu, Minghua Wu, Juanjuan Xiang. State Intellectual Property Office of the People’s Republic of China, patent issued on Oct 15, 2021, ZL 201911178499.4. 
  12. Methods and compositions for diagnosing depression. Rima Kaddurah-Daouk,……Wei Jia, et al. International application No. PCT/US2020/021433, Filing date: Sept 17, 2020. 
  13. Application of diagnostic markers for neonatal biliary atresia. Wei Jia, Guoxiang Xie, Kejun Zhou. State Intellectual Property Office of the People’s Republic of China, No. 202011510885.1, on Dec 18, 2020 
  14. A method and metabolite array relating to the quantitative analysis of multiple metabolites in biological samples, Wei Jia, Guoxiang Xie, Lu Wang, State Intellectual Property Office of the People’s Republic of China, patent issued on June 30, 2020, CN201811223486.X. 
  15. Fructose analogs and their combinations as anti-cancer agents, Inventor: Wei Jia and Wenlian Chen, US patent No: US 10,441,564 B2, issued on Oct. 15, 2019. 
  16. A methods and kits relating to a metabolite biomarker panel for the diagnosis of pancreatic cancer, Wei Jia, Guoxiang Xie, Aihua Zhao, Jiajian Liu, State Intellectual Property Office of the People’s Republic of China, ZL 201410624200.4, patent issued on Oct 18, 2018, CN105675735B. 
  17. A methods and kits relating to a metabolite biomarker panel for the diagnosis of breast cancer, Wei Jia, Guoxiang Xie, Aihua Zhao, Jiajian Liu, State Intellectual Property Office of the People’s Republic of China, ZL 2014 1 0664535.9, patent issued on July 17, 2018, CN105675735B. 
  18. Liver disease-related biomarkers and methods of use thereof, Inventor: Wei Jia, International application No. PCT/US2017/034915, Filing date: May 29, 2017.  Diabetes-related biomarkers and treatment of diabetes-related condition, Inventor: Wei Jia, International application No. PCT/US16/57538, Filing date: 18 October 2016, Confirmation No. 2974. 
  19. Methods and kits for assessing risk of diabetes and treatment evaluation, Wei Jia, et al, State Intellectual Property Office of the People’s Republic of China, ZL 2015 1 0733880.8. Patent issued on Jan 5, 2021.

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