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GUO Shangchun  

  • Doctoral Supervisor, Professor
  • Department: Orthopedics
  • Research Area: Bio-functionalized new materials and modularized exosomes; Regeneration rehabilitation and biomechanics of the motor system diseases
  • Research Interests: The role and molecular mechanism of natural nanomaterials in tissue damage function of diseases in the locomotor system; The mechanism of bone and cartilage regeneration and repair, the mechanism and treatment of osteoarthritis rehabilitation, and the role of biomechanics in the regeneration of diseases in the motor system
  • Contact: achuni@126.com; scguo@shsmu.edu.cn
Biography Positions Publications Research Projects Patents
  • Research Fellow, Department of Orthopedics, Shanghai Sixth People’s Hospital
  • Associate Research Fellow, Department of Orthopedics, Shanghai Sixth People’s Hospital, 2023
  • Visiting Scholar, Oxford Brookes University, 2019
  • Research Associate, Shanghai Sixth People’s Hospital, 2018
  • PhD from Shanghai Jiao Tong University, 2016
  • Research Intern, Shanghai Sixth People’s Hospital, 2007
  • MA from Shanghai Jiao Tong University School of Medicine, 2003
  • Physician, Department of Stomatology, Third People’s Hospital of Huangmei County, Hubei Province, 2000
  • MB from Norman Bethune University of Medical Sciences, 1999
  • Research Fellow, Department of Orthopedics, Shanghai Sixth People’s Hospital
  1. Liu P-L, He S-H, Shen Z-H, Li X-R, Deng Q-S, Wei Z-Y, Zhang C-R, Dou X-Q, Zhu T-H, Dawes H, Lu J, Guo S-C#, Tao S-C. Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer-Specific Release of CK2.1 and the “Exercise Hormone” Lac-Phe for Enhanced Osteochondral Regeneration [J]. Advanced Healthcare Materials, 2024, https://doi.org/10.1002/adhm.202402329
  2. Deng Q-S, Li X-R, Liu P-L, He S-H, Gao Y, Han Z-Y, Shen Z-H, Wei Z-Y, Zhang C-R, Wang F, Dawes H, Zhu T-H, Guo S-C#, Tao S-C. 3D Cryo-Printed Hierarchical Porous Scaffolds Harmonized with Hybrid Nanozymes for Combinatorial Mitochondrial Therapy: Enhanced Diabetic Bone Regeneration via Micromilieu Remodeling [J]. Advanced Functional Materials, 2024, https://doi.org/10.1002/adfm.202403145
  3. Deng Q S, Gao Y, Rui B Y, Li X R, Liu P L, Han Z Y, Wei Z Y, Zhang C R, Wang F, Dawes H, Zhu T H, Tao S C, Guo S C#. Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles: Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus [J]. Bioact Mater, 2023, http://doi.org/10.1016/j.bioactmat.2023.04.004
  4. Tao S C, Li X R, Wei W J, Wei Z Y, Zhang C R, Wang F, Dawes H, Guo S C#. Polymeric coating on β-TCP scaffolds provides immobilization of small extracellular vesicles with surface-functionalization and ZEB1-Loading for bone defect repair in diabetes mellitus [J]. Biomaterials, 2022, http://doi.org/10.1016/j.biomaterials.2022.121465
  5. Tao S C, Huang J Y, Gao Y, Li Z X, Wei Z Y, Dawes H, Guo S C#. Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis [J]. Bioact Mater, 2021, http://doi.org/10.1016/j.bioactmat.2021.04.031
  • 01/01/2024-12/31/2027
    National Natural Science Foundation of China (Key Program), ¥490,000, 82372566
    Mechanistic Study on the Treatment of Osteoarthritis by Exercise-Mimicking Exosomes Loaded with Clusterin to Regulate Macrophage-Chondrocyte Interaction
    Role: Principal Investigator
  • 01/01/2023-12/31/2025
    Shanghai Jiao Tong University School of Medicine “Two-Hundred Talent” Program, ¥1000,000, 2022-17
    Role: Principal Investigator
  • 01/01/2021-12/31/2024
    National Natural Science Foundation of China (Key Program), ¥550,000, 82072530
    Mechanistic Study on Modular Exosomes Carrying LINC01001 to Regulate IGF2BP2's m6A Selective Recognition Function for the Prevention and Treatment of Osteoarthritis
    Role: Project leader
  • 11/01/2019-10/31/2021
    the Shanghai Pujiang Program, ¥300,000,2019PJD038
    Mechanistic Study on Exosomes Surface-Modified with Silver Nanoparticles to Promote the Repair of Chronic Osteomyelitis
    Role: Principal Investigator
  • 01/01/2019-12/31/2022
    National Natural Science Foundation of China (Key Program), ¥570,000, 81871834
    Mechanistic Study on LncRNA H19 Delivered by Exosomes to Regulate Chondrocyte Autophagy for the Prevention and Treatment of Osteoarthritis
    Role: Principal Investigator
  • 01/01/2019-12/31/2021
    National Natural Science Foundation of China,¥210,000, 81802226
    Mechanistic Study on Exosome-Delivered Circular RNA circ77 as a ceRNA to Regulate Chondrocyte Function and Its Role in the Treatment of Osteoarthritis
    Role: Participant
  • 01/01/2018-12/31/2021
    National Natural Science Foundation of China,¥550,000,81772426
    Application of Functionalized Exosome-Based Targeted Delivery Strategies in Gene Therapy for Heterotopic Ossification
    Role: Participant
  • 01/01/2017-12/31/2020
    National Natural Science Foundation of China,¥520,000, 81672143
    Mechanistic Study on the Role of the TLR4/NF-κB Pathway and Related Inflammatory Factors in the Onset and Progression of Glucocorticoid-Induced Femoral Head Necrosis
    Role: Participant
  • 01/01/2016-12/31/2019
    National Natural Science Foundation of China,¥590,000, 81572223
    Role and Mechanism of Stem Cell-Derived Exosomes Delivering miR-720 in Regulating Endothelial Tip Cell Specialization and Promoting Angiogenesis
    Role: Participant
  • 01/01/2016-12/31/2018
    National Natural Science Foundation of China,¥180,000, 81501865
    Construction of a Nanofiber Scaffold Incorporating Platelet-Rich Plasma and Its Repair Effect on Cartilage Defects
    Role: Participant
  • 01/01/2016-12/31/2019
    National Natural Science Foundation of China,¥570,000, 81572120
    Mechanistic Study on iPS-MSC-Derived Exosomes Activating the PI3K/Akt Pathway to Promote Bone Regeneration
    Role: Participant
  • 01/01/2015-12/31/2018
    National Natural Science Foundation of China,¥720,000, 81472152
    Role and Mechanism of Bioengineered iPS-MSC-Derived Exosomes in Repairing Ischemic Tissue Injury
    Role: Participant
  • 01/01/2015-12/31/2018
    National Natural Science Foundation of China,¥250,000, 81400855
    Study on the Role of Transcription Factor TBX3 in Regulating Osteoclast Function and the Pathogenesis of Osteoporosis
    Role: Participant
  • 01/01/2014-12/31/2016
    National Natural Science Foundation of China,¥230,000, 81301589
    Signaling Mechanism of miR-34a Regulating Chondrocyte Proliferation and Differentiation in Osteoarthritis via the SIRT1-Notch-Sox9 Pathway
    Role: Participant
  • 01/01/2014-12/31/2016
    National Natural Science Foundation of China,¥230,000, 81301589
    Signaling Mechanism of miR-34a Regulating Chondrocyte Proliferation and Differentiation in Osteoarthritis via the SIRT1-Notch-Sox9 Pathway
    Role: Principal Investigator
  • 01/01/2011-12/31/2014
    National Natural Science Foundation of China,¥330,000, 81071501
    Role of Coarse-Focused High-Energy Shock Waves in the Treatment of Osteoporotic Fractures
    Role: Participant
  • 01/01/2011-12/31/2014
    National Natural Science Foundation of China,¥320,000, 81071134
    Dynamic Evaluation of the Effects and Mechanism of Leptin Intervention on Osteoporotic Rabbit Models Using MRS and Micro-CT
    Role: Participant
  • 01/01/2011-12/31/2013
    National Natural Science Foundation of China,¥180,000, 30801221
    Mechanistic Study on Platelet-Rich Plasma in Repairing Chronic Non-Healing Wounds
    Role: Participant
  • 01/01/2010-12/31/2012
    National Natural Science Foundation of China,¥160,000, 30700850
    Study on Enhancing Chemotherapy Sensitivity in Drug-Resistant Osteosarcoma by Dual-Channel Downregulation of bcl-2 and cyclinD1 Genes Using RNA Interference Technology
    Role: Participant
  • 01/01/2007-12/31/2010
    National Natural Science Foundation of China,¥250,000, 30571898
    Study on the Mechanism and Therapeutic Effect of High-Energy Shock Waves in Early Femoral Head Necrosis
    Role: Participant
  • 01/01/2006-12/31/2006
    National Natural Science Foundation of China,¥80,000, 30471747
    Mechanistic Study on Platelet-Rich Plasma in Promoting Bone Defect Repair
    Role: Participant
  1. [Shicong Tao, Shangchun Guo] (2023), “A Suture-Free Labral Repair Rivet and Labral Repair Method”, PCT/201910675500.8; ZL201911060902.3
  2. [Shicong Tao, Shangchun Guo] (2023), “A Rivet Assembly for One-Step Insertion and One-Step Insertion Method for Rivet”, PCT/CN201911061114.6; ZL201911061114.6
  3. [Shicong Tao, Shangchun Guo] (2020), “A Simple Device for Preparing Exosome Sustained-Release Gel”, PCT/CN201911060570.9; ZL201921869931.X
  4. [Shicong Tao, Shangchun Guo] (2020), “An Exosome Filtration and Extraction Device”, ZL201921178794.5
  5. [Shicong Tao, Shangchun Guo] (2020), “An Intelligent Glove for Hand Function Assessment”, PCT/CN201910675373.1; ZL201921178785.6
  6. [Shangchun Guo, Shicong Tao] (2020), “An Exosome Identification Device”, PCT/CN201910675418.5; ZL201921187834.2
  7. [Shicong Tao, Shangchun Guo] (2020), “A Soft Robot and Arthroscope, Grinding Cobalt, Electric Drill, and Rivet Holder”, PCT/CN201911060605.9; ZL201921871042.7
  8. [Shicong Tao, Shangchun Guo] (2020), “A Visualized Acetabular Prosthesis Insertion Device”, PCT/CN201911061736.9; ZL201921870270.2
     

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