GUO Shangchun  

  • Graduate Supervisor, Researcher
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Biofunctionalized materials and Engineered exosomes;  Regenerative Rehabilitation of Locomotor Diseases and Biomechanics
  • Contact: scguo@shsmu.edu.cn
  • Fellowship, Shanghai Medical Association, Orthopaedics, Physical Medicine & Rehabilitation Medicine, Sports Medicine, 2022
  • Visiting Scholar, Oxford Brooks University, UK, 2018
  • MD from Shanghai Jiao Tong University School of Medicine, 2016
  • PhD from Shanghai Jiao Tong University School of Medicine, 2003
  • Researcher, Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital
  • Deputy Editor in Chief, BMC Molecular and Cell Biology
  • Guest Editor,  BioMed Research International
  • Guest Vice Editor in Chief, Frontiers in Molecular Biosciences 
  • Deputy Editor in Chief, BMC Musculoskeletal Disorders
  • Guest Associate Editor in Chief, Frontiers in Bioengineering and Biotechnology 
  • Member, the Communications Committee of Osteoarthritis Research Society International (OARSI)
  • Member, Shanghai Biomaterials Professional Committee
  • Member,  the Shanghai Oral Materials Professional Committee
  • Member,  the International Committee on Extracellular Vesicle Communications
  • Members at Large, International Society for Extracellular Vehicles (ISEV)
  1. Qing-Song Deng, Yuan Gao, Bi-Yu Rui, Xu-Ran Li, Po-Lin Liu, Zi-Yin Han, Zhan-Ying Wei, Chang-Ru Zhang, Fei Wang, Helen Dawes, Tong-He Zhu, Shi-Cong Tao, Shang-Chun Guo, Double-network hydrogel enhanced by SS31-loaded mesoporous polydopamine nanoparticles: Symphonic collaboration of near-infrared photothermal antibacterial effect and mitochondrial maintenance for full-thickness wound healing in diabetes mellitus, Bioactive Materials,2023, doi:10.1016/j.bioactmat.2023.04.004.
  2. Tao SC, Li XR, Wei WJ, Wei ZY, Zhang CR, Wang F, Dawes H, Guo SC. Polymeric coating on β-TCP scaffolds provides immobilization of small extracellular vesicles with surface-functionalization and ZEB1-Loading for bone defect repair in diabetes mellitus. Biomaterials. 2022 Apr;283:121465. doi: 10.1016/j.biomaterials.2022.121465.
  3. Tao SC, Huang JY, Gao Y, Li ZX, Wei ZY, Dawes H, Guo SC. Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. Bioact Mater. 2021 May 6;6(12):4455-4469. doi: 10.1016/j.bioactmat.2021.04.031.
  4. Tao SC, Guo SC. Role of extracellular vesicles in tumour microenvironment. Cell Commun Signal. 2020 Oct 20;18(1):163. doi: 10.1186/s12964-020-00643-5.
  5. Lu J, Guo SC, Wang QY, Sheng JG, Tao SC. J-bone graft with double locking plate: a symphony of mechanics and biology for atrophic distal femoral non-union with bone defect. J Orthop Surg Res. 2020 Apr 15;15(1):144. doi: 10.1186/s13018-020-01636-3.
  6. Lu J, Wang QY, Sheng JG, Guo SC, Tao SC. A 3D-printed, personalized, biomechanics-specific beta-tricalcium phosphate bioceramic rod system: personalized treatment strategy for patients with femoral shaft non-union based on finite element analysis. BMC Musculoskelet Disord. 2020 Jul 1;21(1):421. doi: 10.1186/s12891-020-03465-1.
  7. Tao, SC., Guo, SC. Extracellular vesicles in bone: “dogrobbers” in the “eternal battle field”. Cell Commun Signal 17, 6 (2019). doi:10.1186/s12964-019-0319-5.
  8. Tao SC, Guo SC, Collett J. A Novel Role for Extracellular Vesicles in Cytopathology and New Therapeutic Strategies. Biomed Res Int. 2019 Nov 11;2019:7137613. doi: 10.1155/2019/7137613.         
  • 01/01/2024-12/31/2027
    National Natural Science Foundation of China, ¥490,000, 82372566
    Study on the Treatment of Osteoarthritis and Its Mechanism by Regulating the Interaction between Macrophages and Chondrocytes with Clusterin in the Simulated-motion Exosomes
    Role: Project leader
  • 01/01/2023-12/31/2025
    National Key Research and Development Project, ¥550,000, 82072530
    Mechanism Study on the Prevention and Treatment of Osteoarthritis by Employing Modularized Exosomes Loaded with LINC01001 Regulating the m6A Selective Recognition Function of IGF2BP2
    Role: Project leader
  1. [Shi-Cong Tao, Shang-Chun Guo] (2019), “Application of Exosome Filtration and Extraction Device and Exosome Extraction Method”, CN 110252440 B; ZL 2019 1 0675500.8
  2. [Shi-Cong Tao, Shang-Chun Guo] (2019), “Application of Suture-free Glenoid Labrum Repair Rivet and Glenoid Labrum Repair Method”, CN 111084644 B; ZL 2019 1 1060902.3
  3. [Shi-Cong Tao, Shang-Chun Guo] (2019), “Application of a Rivet Assembly that Facilitates One-step Placement and One-step Method for Inserting Rivets”, CN 110811717 B; ZL 2019 1 1061114.6
  4. [Shi-Cong Tao, Shang-Chun Guo] (2019), “Application of a Rivet Assembly that Facilitates One-step Placement and One-step Method for Inserting Rivets”, CN 110811717 B; ZL 2019 1 1061114.6

Convertion Achievements:

  • [Yang Wang, Jun-Jie Guan, Zhi-Feng Deng, Chang-Qing Zhang, Fei-Xiang Gong, Xin Niu, Shou-Fu Tian, Shang-Chun Guo] (2012),“Extraction and Amplification Culture Method and Application of  Urine Mesenchymal Stem Cells”, CN 201210470118.1; IPC/LOC:C12N5/0775(2010.01)I; ZL201210470118.1
  • [Shi-Cong Tao, Shang-Chun Guo] (2016),“An Acquisition Method and Application of Exosome Derived From Urine Cells”, ZL201610022096.0
  • [Shi-Cong Tao, Shang-Chun Guo] (2018),“An Exosome Sustained-release System and its Construction Method and Application”, 201810136419.8
  • [Shi-Cong Tao, Shang-Chun Guo] (2018),“Application of Resveratrol-loaded Human Pluripotent Stem Cell Exosome in Preparation of Drugs for Treating Bone and Joint Degenerative Diseases”, 201810136419.8