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GUI Dingkun  

  • Chief Physician, Doctoral Supervisor
  • Department: Nephrology
  • Research Area: Internal Medicine (Nephrology)
  • Research Interests: Pathogenesis of diabetic nephropathy and the prevention and treatment of the combination of Chinese and Western medicine
  • Contact: dingkungui@sjtu.edu.cn
Biography Positions Publications Patents Other
  • Bachelor's Degree from Hubei University of Traditional Chinese Medicine, 2001
  • Master's Degree from Guangzhou University of Traditional Chinese, 2004 
  • PhD from Shanghai Medical College, Fudan University, 2007
  • Chief Physician, Department of Nephrology, Shanghai Sixth People's Hospital
  1. Shen Y, Chen W, Lin K, Zhang H, Guo X, An X, Yang L, Wang N, Xu Y, Gui D. Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway. Phytomedicine, 2024, 126:155445.
  2. Liu Y, Sun Z, Dong R, Liu P, Zhang X, Li Y, Lai X, Cheong HF, Wu Y, Wang Y, Zhou H, Gui D, Xu Y. Rutin ameliorated lipid metabolism dysfunction of diabetic NAFLD via AMPK/SREBP1 pathway. Phytomedicine, 2024, 126:155437. 
  3. Dong R, Zhang X, Liu Y, Zhao T, Sun Z, Liu P, Xiang Q, Xiong J, Du X, Yang X, Gui D, Xu Y. Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease. Phytomedicine, 2023, 112:154700. 
  4. Wei M, Gao Y, Cheng D, Zhang H, Zhang W, Shen Y, Huang Q, An X, Wang B, Yu Z, Wang N, Chen H, Xu Y, Gui D. Notoginsenoside Fc ameliorates renal tubular injury and mitochondrial damage in acetaminophen-induced acute kidney injury partly by regulating SIRT3/SOD2 pathway. Front Med (Lausanne), 2023, 9:1055252.
  5. Li X, Zhao T, Gu J, Wang Z, Lin J, Wang R, Duan T, Li Z, Dong R, Wang W, Hong KF, Liu Z, Huang W, Gui D, Zhou H, Xu Y. Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis. Chin Med, 2022, 17(1):22..
  6. Huang Q, Chen H, Yin K, Shen Y, Lin K, Guo X, Zhang X, Wang N, Xin W, Xu Y, Gui D. Formononetin Attenuates Renal Tubular Injury and Mitochondrial Damage in Diabetic Nephropathy Partly via Regulating Sirt1/PGC-1α Pathway. Front Pharmacol, 2022, 13:901234.
  7. Su J, Gao C, Xie L, Fan Y, Shen Y, Huang Q, Wang N, Xu Y, Yang N, Gui D. Astragaloside II Ameliorated Podocyte Injury and Mitochondrial Dysfunction in Streptozotocin-Induced Diabetic Rats. Front Pharmacol, 2021,12:638422.
  8. Xue R, Zhai R, Xie L, Zheng Z, Jian G, Chen T, Su J, Gao C, Wang N, Yang X, Xu Y, Gui D, Xuesaitong protects podocytes from apoptosis in diabetic rats through modulating PTEN-PDK1-Akt-mTOR pathway. J Diabetes Res, 2020, 2020:9309768.
  9. Xie L, Zhai R, Chen T, Gao C, Xue R, Wang N, Wang J, Xu Y, Gui D, Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats. Drug Des Devel Ther, 2020, 14:527-538.
  10. Zhai R, Jian G, Chen T, Xie L, Xue R, Gao C, Wang N, Xu Y, Gui D. Astragalus membranaceus and Panax notoginseng, the novel renoprotective compound, synergistically protect against podocyte injury in streptozotocin-induced diabetic rats. J Diabetes Res, 2019, 2019:1602892.
  1. Niansong Wang, Dingkun Gui, Xiaoxia Wang, Feng Wang, Ying Fan. Drug screening method for early diabetic nephropathy based on podocyte adhesion. 2011-5-23, China, Patent No. ZL201110132673.9.
  • Niansong Wang, Ying Fan, Limin Lu, Dingkun Gui, Feng Wang, Xiaoxia Wang, Hong Xue, Li Zhou, Guihua Jian, Tingfang Chen, “New mechanisms of diabetic nephropathy and new strategies for clinical diagnosis and treatment”, Second Prize of Shanghai Science and Technology Progress Award in 2019.
  • Niansong Wang, Guihua Jian, Lianbo Wei, DingkunGui, Ying Fan, Feng Wang,Junhui Li, Yanfang Chen, Dongsheng Cheng, Xiaoxia Wang, Xiaohua Sheng, Xufeng Yang, Junnan Wu, Yang Fei, Jiejun Wen,  “New exploration of the pathogenesis of diabetic nephropathy and the prevention and treatment of the combination of Chinese and western medicine”, First Prize of Science and Technology Award of Chinese Association of Integrative Medicine in 2017.
  • Niansong Wang, Ying Fan, Dingkun Gui, Feng Wang, Junhui Li, Dongsheng Cheng,Junnan Wu,Yang Fei, Jiejun Wen, Yanfang Chen, Guihua Jian, Xiaohua Sheng,” New exploration of pathogenesis of diabetic nephropathy and evaluation of its clinical application”, Second Prize of Shanghai Medical Science and Technology Award in 2017.

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