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GUAN Jian
- Chief Physician, Doctoral Supervisor
- Department: ENT & HN Surgery
- Research Area: Otolaryngology
- Research Interests: Pathogenesis of OSAHS
- Contact: guanjian0606@sina.com
- Chief Physician, Shanghai Sixth People's Hospital, 2022-present
- Associate Chief Physician, Shanghai Sixth People's Hospital, 2019-2022
- Attending Physician, Shanghai Sixth People's Hospital, 2011-2018
- Resident Physician, Shanghai Sixth People's Hospital, 2009-2011
- Resident Physician, the First People's Hospitol of Lianyungang, 1995-2000
- MD/PhD from Shanghai Jiao Tong University School of Medicine, 2009
- MM from Shanghai Second Medical University, 2004
- BMed from Nanjing Medical University, 1995
- Committee Member, Chinese Society of Otolaryngology-Head and Neck Surgery Pharyngology Branch
- Committee Member, China International Exchange and Promotive Association for Medical and Health Care Sleep Branch
- Committee Member, China International Exchange and Promotive Association for Medical and Health Care Phoniatrics and Logopedics Branch
- Deputy Head, Vocal Studies Group of Shanghai Medical Association Otolaryngology Branch
- Committee Member, Sleep Medicine Professional Committee of Shanghai Medical Association
- Li X, Wang F, Gao Z, Huang W, Zhang X, Liu F, Yi H, Guan J#, Wu X#, Xu H#, Yin S. Melatonin attenuates chronic intermittent hypoxia-induced intestinal barrier dysfunction in mice. Microbiol Res., 2023, doi: 10.1016/j.micres.2023.127480.
- Zhang X, Li X, Xu H#, Fu Z, Wang F, Huang W, Wu K, Li C, Liu Y, Zou J, Zhu H, YiH, Su K, Gu M#, Guan J#, Yin S. Changes in the oral and nasal microbiota in pediatric obstructive sleep apnea. J Oral Microbiol., 2023, doi: 10.1080/20002297.2023.2182571.
- Wang F; Zou J; Xu H; Hu W; Zhang X; Wei Z; Li X; Liu Y; Zou J; Liu F; Zhu H; Yi J; Guan J#; Yin S#. Effects of Chronic Intermittent Hypoxia and Chronic Sleep Fragmentation on Gut Microbiome, Serum Metabolome, Liver and Adipose Tissue Morphology. Front Endocrinol(Lausanne), 2022, doi: 10.3389/fendo.2022.820939.
- Xu H, Liu F, Li Z, Li X, Liu Y, Li N, Zhang X, Gao Z, Zhang X, Liu Y, Zou J, Meng L, Liu S, Zhu H, Tang X, Wu H, Su K, Chen B, Yu D, Ye H, Chen H, Yi H, Guan J*, Yin S, Shi Y. Genome-Wide Association Study of Obstructive Sleep Apnea and Objective Sleep-Related Traits Identifies Novel Risk Loci in Han Chinese Individuals. Am J Respir Crit Care Med., 2022, doi: 10.1164/rccm.202109-2044OC.
- Xu H, Liang C, Zou J, Yi H, Guan J#, Gu M#, Feng Y#, Yin S. Interaction between obstructive sleep apnea and short sleep duration on insulin resistance: a large-scale study : OSA, short sleep duration and insulin resistance. Respir Res., 2020, doi: 10.1186/s12931-020-01416-x.
- Qian Y, Zou J, Xu H, Zhu H, Meng L, Liu S, Yi H#, Guan J#, Yin S. Association of upper airway surgery and improved cardiovascular biomarkers and risk in OSA. Laryngoscope, 2020, doi: 10.1002/lary.28012.
- Xia Y, Zou J, Xu H#, Yi H, Guan J#, Yin S. Effect modification by gender of the influence of obstructive sleep apnoea characteristics on dyslipidaemia in China: a cross-sectional study. BMJ Open., 2019, doi: 10.1136/bmjopen-2018-028509.
- Zhao X, Xu H, Qian Y, Liu Y, Zou J, Yi H, Guan J*, Yin S*. Abdominal Obesity Is More Strongly Correlated with Obstructive Sleep Apnea than General Obesity in China: Results from Two Separated Observational and Longitudinal Studies. Obes Surg., 2019, doi: 10.1007/s11695-019-03870-z.
- Tan J, Fu L, Chen H, Guan J*, Chen Y, Fang J. Association study of genetic variation in the autophagy lysosome pathway genes and risk of eight kinds of cancers. Int J Cancer., 2018, doi: 10.1002/ijc.31288.
- Zou J, Xia Y, Xu H, Fu Y, Qian Y, Li X, Zhao X, Zou J, Meng L, Liu S, Zhu H, Yi H, Guan J*, Chen B*, Yin S*. Independent relationships between cardinal features of obstructive sleep apnea and glycometabolism: a cross-sectional study. Metabolism., 2018, doi: 10.1016/j.metabol.2017.11.021.
- 01/01/2024-12/31/2026
National Natural Science Foundation of China (Key Program), ¥1,400,000, 82341242
Neural modulatory Mechanisms underlying Sleep Fragmentation and Intervention Strategy Study (B)
Role: Project leader - 01/01/2023-12/31/2026
National Natural Science Foundation of China (General Program), ¥520,000, 82271153
The Role and Mechanism of BTBD9-Mediated Protein Ubiquitination Modification in OSAHS Sleep-Wake Disorders
Role: Project leader - 12/01/2021-11/30/2026
This work was supported by the Ministry of Science and Technology of the People's Republic of China (STI2030-Major Projects), ¥3,000,000, 2021ZD0201900
The Brain Network Characteristics of Sleep Disorders and the Neural Regulatory Mechanisms of Brain Cognition
Role: Principal Investigator - 01/01/2020-12/31/2023
National Natural Science Foundation of China (General Program), ¥590,000, 81970870
The Effects and Mechanisms of OSAHS Gut Microbiota Disorder on the 5-HT Neural Pathway and Genioglossal Muscle Function
Role: Project leader - 10/01/2020-09/30/2022
Shanghai Hospitol Development Center Project, ¥1,000,000, SHDC2020CR3056B
Establishment and Application of a New Diagnostic Technology for Obstructive Sleep Apnea Hypopnea Syndrome Based on AI Technology
Role: Project leader
- [Guan Jian, Yin Shankai, Yi Hongliang, Sheng bin, Li Huating, Liu Ruhan, Xu Huajun] (2022), “Method, device, computer equipment, and storage medium for analyzing blood oxygen saturation signals”, ZL 2020 1 0003990.X
- [Li Chenyang, Wang Fan, Guan Jian, Xu Huajun, Liu Yupu, Yin Shankai] (2021), "A simulated animal model device for sleep apnea hypopnea syndrome", ZL 2020 2 27788511.8
