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GAO Junjie
- Graduate Supervisor, Associate Researcher
- Department: Orthopedics
- Research Area: Surgery (Orthopedics)
- Research Interests: Regulation of bone-brain axis, bone metabolism, and bone homeostasis
- Contact: colingjj@163.com
- Postdoctoral Fellow, Shanghai Sixth People's Hospital, Department of Orthopedics, 2020
- Postdoctoral Fellow, University of Western Australia, School of Surgery, Bone Research Laboratory, 2018
- PhD from The University of Western Australia, Biological Science, 2017
- Associate researcher, Department of Orthopedics, Shanghai Sixth People's Hospital
- Associate Researcher, Shanghai Jiao Tong University School of Medicine
- Member and Secretary, the Basic Society of Orthopedics Branch of Shanghai Medical Association
- Lifetime Member, the International Chinese Musculoskeletal Research Society
- Gao Junjie., Qin An., Liu Delin., Ruan Rui., Wang Qiyang., Yuan Jun., Cheng Tak Sum., Filipovska Aleksandra., Papadimitriou J M., Dai Kerong., Jiang Qing., Gao Xiang., Feng Jian Q., Takayanagi Hiroshi., Zhang Changqing., Zheng Ming H.(2019). Endoplasmic reticulum mediates mitochondrial transfer within the osteocyte dendritic network. Sci Adv, 5(11), eaaw7215. doi:10.1126/sciadv.aaw7215
- Liao, P., Chen, L., Zhou, H., Mei, J., Chen, Z., Wang, B., Feng, J. Q., Li, G., Tong, S., Zhou, J., Zhu, S., Qian, Y., Zong, Y., Zou, W., Li, H., Zhang, W., Yao, M., Ma, Y., Ding, P., Pang, Y., … Gao, J. (2024). Osteocyte mitochondria regulate angiogenesis of transcortical vessels. Nature communications, 15(1), 2529. https://doi.org/10.1038/s41467-024-46095-0
- Zhou, H., Zhang, W., Li, H., Xu, F., Yinwang, E., Xue, Y., Chen, T., Wang, S., Wang, Z., Sun, H., Wang, F., Mou, H., Yao, M., Chai, X., Zhang, J., Diarra, M. D., Li, B., Zhang, C., Gao, J., & Ye, Z. (2024). Osteocyte mitochondria inhibit tumor development via STING-dependent antitumor immunity. Science advances, 10(3), eadi4298. https://doi.org/10.1126/sciadv.adi4298
- Zhang, W., Zhou, H., Li, H., Mou, H., Yinwang, E., Xue, Y., Wang, S., Zhang, Y., Wang, Z., Chen, T., Sun, H., Wang, F., Zhang, J., Chai, X., Chen, S., Li, B., Zhang, C., Gao, J., & Ye, Z. (2023). Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria. Cell reports, 42(12), 113464. https://doi.org/10.1016/j.celrep.2023.113464
- Ding Peng., Gao Chuan., Gao Youshui., Liu Delin., Li Hao., Xu Jun., Chen Xiaoyi., Huang Yigang., Zhang Changqing., Zheng Minghao., Gao Junjie.(2022). Osteocytes regulate senescence of bone and bone marrow. Elife, 11(undefined), undefined. doi:10.7554/eLife.81480
- Liu Delin., Gao Youshui., Liu Jiao., Huang Yigang., Yin Junhui., Feng Yuyao., Shi Linjing., Meloni Bruno P., Zhang Changqing., Zheng Minghao., Gao Junjie.(2021). Intercellular mitochondrial transfer as a means of tissue revitalization. Signal Transduct Target Ther, 6(1), 65. doi:10.1038/s41392-020-00440-z
- Chen, L., Zhou, M., Li, H., Liu, D., Liao, P., Zong, Y., Zhang, C., Zou, W., & Gao, J. (2023). Mitochondrial heterogeneity in diseases. Signal transduction and targeted therapy, 8(1), 311. doi.org/10.1038/s41392-023-01546-w
- 01/01/2021-12/31/2023
National Natural Science Foundation of China (The Youth Science Fund Project), ¥240,000, 82002339
The function and mechanism investigations of glucocorticoid induces osteoporosis via PINK1-mediated inhibition of mitochondrial transfer between osteocytes
Role: Project leader - 01/01/2019-12/31/2023
National Natural Science Foundation of China (International (regional) cooperation and exchange programs), ¥2,410,000, 81820108020
Costal chondral autograft for reconstruction of chondral defects of the femoral head and its relative mechanism
Role: Principal Investigator - 11/01/2023-10/31/2026
National Key Research and Development Program Youth Science Award project, ¥3,000,000, 2023YFC2509600
Establishment and key technology research of diagnosis and treatment system of bone and soft tissue infection based on immune regulatory network
Role: Principal Investigator - 09/01/2020-07/31/2023
Scientific Research Fund of Shanghai Sixth People's Hospital, ¥500,000, X-2265,
Mechanism of Parkin inhibiting mitochondrial transport between osteocytes leading to steroid-induced osteoporosis
Role: Project leader - 09/01/2018-08/31/2020
The 66th batch of General projects of China Postdoctoral Science Foundation, ¥80,000, 2019M661522,
Secreted autophagy of osteocytes mediates steroid-induced osteoporosis
Role: Project leader - 03/01/2021-02/28/2022
Cooperative project of Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, ¥550,000, 2020YJY0220,
Establishment and application of a new mouse model of osteoporosis
Role: Project leader
- [Junjie Gao, Changqing Zhang, Yiyang Ma] (2023), “A kit and method for extracting mitochondria from cells in vitro”, CN202311450225.2
- [Junjie Gao, Changqing Zhang, Yiyang Ma] (2023), “The use of ketoconazole in the preparation of drugs for the treatment of degenerative osteoarthritis”,CN202311457553.5
- [Junjie Gao, Yiyang Ma, Changqing Zhang] (2023), “Application of L-carnitine or L-carnitine acetylated derivatives”, CN202311359049.1
- [Junjie Gao, Changqing Zhang, Hao Li, Yiyang Ma] (2023),“Application of adenosine diphosphate”, CN202311307325.X
- [Junjie Gao, Changqing Zhang, Peng Liao, Yiyang Ma] (2023),“Application of iMSCs mitochondria in the preparation of drugs for the treatment of bone defects”, CN202311299914.8
- [Junjie Gao, Peng Liao, Delin Liu, Changqing Zhang] (2023), “Application of sphingosine solution in the preparation of drugs promoting bone penetrating cortical angiogenesis”, CN202310192662.2
- [Junjie Gao, Wenkan Zhang, Zhaoming Ye, Changqing Zhang] (2022), “Use of platelets or platelets that inhibit mitochondrial activity in the preparation of cancer suppressive agents”, CN202210570219.X
