FU Qiang  

  • Doctoral Supervisor, Professor
  • Department: Urology
  • Research Area: Surgery (Urology)
  • Research Interests: Tissue engineering and urethral reconstruction and repair
  • Contact: Jamesqfu@aliyun.com
  • M.D. from Shanghai Second Medical University, 2005
  • MMed from Shanghai Second Medical University, 1998
  • BMed from Shanghai Second Medical University, 1991
  • Director, Department of Urology, Shanghai Sixth People's Hospital
  • Member, Urology Society of Chinese Medical Association
  • Vice chairman, Urology Society of Shanghai Medical Association
  • Vice chairman, Basic and Research Group of the Chinese Urological Association
  • Member, American Urological Association
  • Vice chairman, International exchange committee of the Chinese Urological Association
  • Member, Chinese Sexology Association
  • Member, Asian Association of Andrology
  • Member, Andrology Society of Chinese Medical Association
  1. Hua Y, Wang K, Huo Y, Fu Q#, et al. Four-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction. Nat Commun. 2023;14(1):7632. Published 2023 Nov 22. doi:10.1038/s41467-023-43421-w
  2. Yang M, Zhang Y, Fang C, Fu Q#, et al. Urine-Microenvironment-Initiated Composite Hydrogel Patch Reconfiguration Propels Scarless Memory Repair and Reinvigoration of the Urethra. Adv Mater. 2022;34(14):e2109522. doi:10.1002/adma.202109522
  3. Zhang, K., Bhutto, M.A., Wang, L., Fu Q#, et al. Double-Layer Nanofibrous Sponge Tube via Electrospun Fiber and Yarn for Promoting Urethral Regeneration. Adv. Fiber Mater. 5, 662–680 (2023). https://doi.org/10.1007/s42765-022-00252-6
  4. Wang L, Wang K, Yang M, Fu Q#, et al. Urethral Microenvironment Adapted Sodium Alginate/Gelatin/Reduced Graphene Oxide Biomimetic Patch Improves Scarless Urethral Regeneration. Adv Sci (Weinh). Published online November 16, 2023. doi:10.1002/advs.202302574
  5. Zhou S, Yang R, Zou Q, Fu Q#, et al. Fabrication of Tissue-Engineered Bionic Urethra Using Cell Sheet Technology and Labeling By Ultrasmall Superparamagnetic Iron Oxide for Full-Thickness Urethral Reconstruction. Theranostics. 2017;7(9):2509-2523. Published 2017 Jun 25. doi:10.7150/thno.18833
  6. Wang Y, Duan M, Rahman M, Fu Q#, et al. Use of bioactive extracellular matrix fragments as a urethral bulking agent to treat stress urinary incontinence. Acta Biomater. 2020;117:156-166. doi:10.1016/j.actbio.2020.09.049
  7. Fu Q, Deng CL, Zhao RY, et al. The effect of mechanical extension stimulation combined with epithelial cell sorting on outcomes of implanted tissue-engineered muscular urethras. Biomaterials. 2014;35(1):105-112. doi:10.1016/j.biomaterials.2013.09.067
  8. Fu Q, Deng CL, Liu W, Cao YL. Urethral replacement using epidermal cell-seeded tubular acellular bladder collagen matrix. BJU Int. 2007 ;99:1162-5
  9. Song L, Deng K, Yuan W, Fu Q#, et al. Anterior substitutional urethroplasty using a biomimetic poly-l-lactide nanofiber membrane: Preclinical and clinical outcomes. Bioeng Transl Med. 2022;7(3):e10308. Published 2022 Mar 11. doi:10.1002/btm2.10308
  10. Fu Q, Zhang YM, Barbagli G, et al. Factors that influence the outcome of open urethroplasty for pelvis fracture urethral defect (PFUD): an observational study from a single high-volume tertiary care center. World J Urol. 2015;33(12):2169-2175. doi:10.1007/s00345-015-1533-4
  • 01/01/2009-12/31/2011
    National Natural Science Foundation of China (General Program), ¥3,000,00, 30973016
    Experimental study on the repair of urinary tract defects by combining adipose stem cell induction technique and bioreactor with in vitro construction of muscular lumen
    Role: Project leader
  • 01/01/2012-12/31/2014
    National Natural Science Foundation of China (General Program), ¥7,000,00, 81270780
    Experimental study on the construction of tissue-engineered urethra by VEGF-loaded magnetic quantum dots combined with cell membrane sheet technology
    Role: Project leader
  • 01/01/2015-12/31/2017
    National Natural Science Foundation of China (General Program), ¥7,300,00, 81470917
    Experimental study of three-dimensional magnetic field orientation combined with magnetic quantum dot-labeled ADSC muscle-forming induction for the treatment of stress urinary incontinence
    Role: Project leader
  • 01/01/2022-12/31/2025
    National Natural Science Foundation of China (General Program), ¥5,500,00, 82170694
    Modulation of pre-vascular neuralization of myofibroblast membrane sheets for remodeling urinary sphincter based on modRNA technology
    Role: Project leader
  • 01/01/2024-12/31/2027
    National Natural Science Foundation of China (General Program), ¥4,900,00, 82370684
    Exploring the mechanism of Hippo-YAP signaling pathway regulating urethral injury repair by constructing a bionic urethral model by using 3D printing and a bioreactor
    Role: Project leader
  • 31/07/2009-30/06/2012
    The Natural Science Foundation of Shanghai, ¥2,000,00, 09ZR1424100
    Experimental study on the repair of urinary tract defects by combining adipose stem cell induction technique and bioreactor with in vitro construction of muscular tubular lumen
    Role: Project leader
  • 31/07/2020-30/06/2023
    The Natural Science Foundation of Shanghai, ¥2,000,00, 20ZR1442100
    Experimental study of pre-vascularized adipose stem cell myogenic induction injection for the treatment of stress urinary incontinence
    Role: Project leader
  • 01/01/2014-12/31/2016
    The Interdisciplinary Program of Shanghai Jiao Tong University, ¥10,000,00
    Study on the construction of pro-vascularization functional tissue-engineered urethra by 3D bioprinting technology
    Role: Project leader
  • 01/01/2022-12/31/2024
    The Interdisciplinary Program of Shanghai Jiao Tong University, ¥10,000,00, YG2022ZD020
    3D bioprinting combined with microfluidics to explore the mechanism of urethral stricture genesis
    Role: Project leader
  1. [Fu Qiang, Zhou Shukui] (2019), “A decellularized matrix material based on adipose stem cell membrane sheet and its preparation method”, CN201610458110.1, CN105963785B
  2. [Yang Ming, Fu Qiang, Yang Yinchao, Wang Ying, Yang Ranxing, Zhang kaile] (2024), “Medical membrane material promoting cell proliferation and its preparation method and application”, CN202110832418.9, CN113521381B
  3. [Yang Ming, Fu Qiang, Yang Yinchao, Wang Ying, Yang Ranxing, Zhang kaile, Liu Meng, Wang Yuhui, Zhang Kun, Zhang Yang] (2022), “A 3D printed stent for urethral repair and reconstruction and its preparation method”, CN202110831025.6, CN113559327B
  4. [Zhang Yaopeng, Chen Jie, Song Lujie, Yuan Wei, Fan Suna, Fu Qiang, Yao Xiang] (2021), “Fabrication of cast-molded bionic capillary network based on 3D printing technology”, CN202010078215.0, CN111733125B 
  5. [Song Lujie, Gu Yubo, Fu Qiang, Yuan Yuxian, Guo Yajing, Wu Jian] (2023), “A urinary catheterization device”, CN202223555557.0, CN219271719U
  6. [Chen Fang, Zheng Yuanyi, Fu Qiang, Hao Junnian, Jia Longyang, Song Lujie, Liu Zhangshun, Feng Chao] (2023), “A kind of ultrasonic physical therapy underwear”, CN202221792478.9, CN219982181U
  7. [Chen Fang, Fu Qiang, Jia Longyang, Yu Mingming, Cai Xiaojun, Xie Xue, Yao Li, Chu Chenlin] (2020), “Wearable flexible ultrasound urethral scar treatment device”, CN201922025232.3, CN211301814U
  8. [Feng Chao, Li Zhe, Lv Xiangguo, Chen Lei, Hu Bin, Xu Yuemin, Wang Huaping, Fu Qiang] (2018), “A method for constructing a segmental individualized human urethral tissue entity model”, CN201510408878.3, CN104992604B

Clinical Translational Results
A total of 53 male patients with anterior urethral stricture were treated with urethral substitution plasty using porcine small intestine submucosa and poly-L-lactic acid (PLLA) nanofibrous membranes, with a success rate of more than 80%, which is comparable to that of autologous tissues, and achieved excellent clinical medical results while avoiding the complications of autologous tissue transplantation, and the related results have been published in high-level journals.

Science & Technology Awards

  1. The second prize of Chinese Medical Science Award, “Innovation and popularization of diagnostic and therapeutic techniques for complex urethral strictures” (2021)
  2. The first prize of Shanghai Medical Science Award, “Innovation and promotion of diagnostic and therapeutic techniques for complex urethral strictures” (2020)
  3. The second prize of Huaxia Medical Science Award, ”Experimental and clinical exploration of repair and reconstruction of the urinary tract with tissue engineering” (2019)
  4. The third prize of Chinese Medical Science Award, “Basic research and clinical application of the use of the tissue engineering technology for the repair of lower urinary tract diseases” (2014)
  5. The second prize of Shanghai Science and Technology Award, “Experimental study and clinical application of lower urinary tract reconstruction by using tissue engineering techniques” (2014)
  6. The second prize of Science and Technology Progress Award of the Ministry of Education, “Experimental study and clinical application of lower urinary tract reconstruction with tissue engineering techniques” (2014)
  7. The third prize of Shanghai Medical Science Award, “Experimental study and clinical application of lower urinary tract reconstruction using tissue engineering techniques” (2012)
  8. The second prize of Chinese Medical Science Award, “Basic research and clinical applications in the treatment of complex urethral diseases” (2011)
  9. The first prize of Science and Technology Progress Award of the Ministry of Education, “Experimental and clinical studies on the treatment of complex urethral strictures and their complications” (2009)
  10. The second prize of Shanghai Medical Science Award, “Experimental and clinical studies on the treatment of male acquired urinary incontinence” (2008)
  11. The third prize of Shanghai Medical Science Award, “Experimental study of epidermal cells as seed cells for the construction of the urethra” (2008)
  12. The second prize of Chinese Medical Science Award, “Experimental and clinical study of autologous tissue reconstruction of the urethra for the treatment of complex urethral strictures” (2007)
  13. The third prize of Shanghai Medical Science Award, “Experimental and clinical study of autologous tissue reconstruction of the urethra for the treatment of complex urethral strictures” (2007)
  14. The second prize of Shanghai Science and Technology Award, “Experimental and clinical study of autologous tissue reconstruction of the urethra for the treatment of complex urethral strictures” (2007)
  15. The third prize of Shanghai Medical Science Award, “Surface-enhanced laser desorption- ionization-time-of-flight-mass spectrometry screening of urinary markers for bladder and kidney cancer” (2006)
  16. The second prize of Shanghai Science and Technology Award, “Micro-probe catheter ultrasound study in the urinary tract” (2006)