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FU Jianliang
- Chief Physician, Doctoral Supervisor
- Department: Neurology
- Research Area: Neurology
- Research Interests: Pathogenesis of vascular dementia
- Contact: fujianliang@163.com
- Doctoral degree from The Second Military Medical University, 2005
- Master's degree from Shandong Medical University, 1999
- Deputy director, Department of Neurology, Shanghai Sixth People's Hospital
- Yaxuan Zhang, Jiawei Zhang, Yao Zhao, Yueqi Zhang , Lan Liu , Xiaofeng Xu, Xiuzhe Wang, Jianliang Fu. ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis.Cell Death Dis. 2023 Nov 6;14(11):721. doi: 10.1038/s41419-023-06237-6.
- Yaxuan Zhang, Yuan Yuan, Jiawei Zhang, Yao Zhao, Yueqi Zhang, Jianliang Fu. Astragaloside IV supplementation attenuates cognitive impairment by inhibiting neuroinflammation and oxidative stress in type 2 diabetic mice. Front Aging Neurosci. 2022 Sep 29:14:1004557. doi: 10.3389/fnagi.2022.1004557. eCollection 2022.
- Yao Zhao, Jiawei Zhang, Yaxuan Zhang, Yueqi Zhang, Xiaojie Zhang, Yaling Zheng, Hongmei Wang, Xiuzhe Wang, Jianliang Fu. Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment. Int Immunopharmacol. 2022 Jul:108:108756. doi: 10.1016/ j.intimp. 2022. 108756. Epub 2022 Apr 6.
- Yao Zhao, Jiawei Zhang, Yaling Zheng, Yaxuan Zhang, Xiao Jie Zhang, Hongmei Wang, Yu Du 1, Jian Guan, Xiuzhe Wang, Jianliang Fu. NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway. J Neuroinflammation. 2021 Sep 16;18(1):207. doi: 10.1186/s12974-021-02250-8.
- Jiawei Zhang, Yaling Zheng, Yao Zhao, Yaxuan Zhang, Yu Liu, Fang Ma, Xiuzhe Wang, Jianliang Fu. Andrographolide ameliorates neuroinflammation in APP/PS1 transgenic mice. Int Immunopharmacol. 2021 Jul:96:107808. doi: 10.1016/j.intimp.2021.107808. Epub 2021 May 30.
- Yaling Zheng, Jiawei Zhang, Yao Zhao, Yaxuan Zhang, Xiaojie Zhang, Jian Guan, Yu Liu, Jianliang Fu. Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis. Int Immunopharmacol. 2021 Apr:93:107422. doi: 10.1016/ j.intimp.2021.107422. Epub 2021 Feb 3.
- Yu Du, Yufei Song, Xiaojie Zhang, Yan Luo, Wenying Zou, Jiawei Zhang, Jianliang Fu. Leptin Receptor Deficiency Protects Mice against Chronic Cerebral Hypoperfusion-Induced Neuroinflammation and White Matter Lesions. Mediators Inflamm. 2020 Dec 18:2020: 7974537. doi: 10.1155/2020/7974537. eCollection 2020.
- Hongmei Wang, Ting Zhang, Xuhua Ge, Jingjiong Chen, Yuwu Zhao, Jianliang Fu. Parkin overexpression attenuates Aβ-induced mitochondrial dysfunction in HEK293 cells by restoring impaired mitophagy. Life Sci. 2020 Mar 1:244:117322. doi: 10.1016/ j.lfs. 2020.117322. Epub 2020 Jan 17.
- Jiawei Zhang, Yu Liu, Yaling Zheng, Yan Luo , Yu Du, Yao Zhao, Jian Guan, Xiaojie Zhang, Jianliang Fu. TREM-2-p38 MAPK signaling regulates neuroinflammation during chronic cerebral hypoperfusion combined with diabetes mellitus. J Neuroinflammation. 2020 Jan 3;17(1):2. doi: 10.1186/s12974-019-1688-9.
- Jiawei Zhang, Yaling Zheng, Yan Luo, Yu Du, Xiaojie Zhang, Jianliang Fu. Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells. Mol Immunol. 2019 Dec:116:29-37. doi: 10.1016/ j.molimm.2019.09.020. Epub 2019 Oct 4.
