FAN Cunyi  

  • Chief Physician, Doctoral Supervisor, Professor
  • Department: Orthopedics
  • Research Area: Surgery (Orthopedics)
  • Research Interests: Limb dysfunction and deformity, bone nonunion and defects, and peripheral nerve injury and compression
  • Contact: fancunyi888@163.com
  • Chief physician, Shanghai Sixth People's Hospital, 2003-present
  • Deputy chief physician, Shanghai Sixth People's Hospital, 1999-2003
  • Attending doctor, Shanghai Sixth People's Hospital, 1994-1999
  • Resident doctor, The Second Affiliated Hospital of Shandong First Medical University, 1987-1991
  • Director, Department of Orthopedics, Shanghai Sixth People's Hospital
  • Vice President, Chinses Hand Surgeons Association
  • Chairman, Shanghai Society for Surgery of the Hand

Representative Basic researches in the latest 5 years since 2019 with IF > 15:

  1. Cai C, Zhang X, Li Y, Liu X, Wang S, Lu M, Yan X, Deng L, Liu S, Wang F, Fan C#. Self-Healing Hydrogel Embodied with Macrophage-Regulation and Responsive-Gene-Silencing Properties for Synergistic Prevention of Peritendinous Adhesion. Adv Mater. 2022 Feb;34(5):e2106564. doi: 10.1002/adma.202106564. (IF = 29.4)
  2. Liu W, Liu A, Li X, Sun Z, Sun Z, Liu Y, Wang G, Huang D, Xiong H, Yu S, Zhang X, Fan C. Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3/pyroptosis axis: Toward a precision therapy. Bioact Mater. 2023 Aug 4;30:169-183. doi: 10.1016/j.bioactmat.2023.06.012. (IF = 18.9)
  3. Yao X, Zhan L, Yan Z, Li J, Kong L, Wang X, Xiao H, Jiang H, Huang C, Ouyang Y, Qian Y, Fan C#. Non-electric bioelectrical analog strategy by a biophysical-driven nano-micro spatial anisotropic scaffold for regulating stem cell niche and tissue regeneration in a neuronal therapy. Bioact Mater. 2022 Jun 13;20:319-338. doi: 10.1016/j.bioactmat.2022.05.034. (IF = 18.9)
  4. Li J, Wang X, Yao Z, Yuan F, Liu H, Sun Z, Yuan Z, Luo G, Yao X, Cui H, Tu B, Sun Z, Fan C#. NLRP3-Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma-Induced Heterotopic Ossification During Aberrant Wound Healing. Adv Sci (Weinh). 2023 Jul;10(19):e2207383. doi: 10.1002/advs.202207383. (IF = 15.1)
  5. Wang S, Yao Z, Zhang X, Li J, Huang C, Ouyang Y, Qian Y, Fan C#. Energy-Supporting Enzyme-Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy. Adv Sci (Weinh). 2022 Nov;9(31):e2202542. doi: 10.1002/advs.202202542. (IF = 15.1)

Representative clinical researches in the latest 5 years since 2019:

  1. Liu W, Xiong H, Wang W, Chen S, Li F, Liu J, Yan H, Zhang J, Qian Y, Fan C#. Effectiveness and safety of a less-invasive MCL reconstruction technique for contracted or ossified ligaments in patients with elbow stiffness: An open-label, non-randomised, prospective, multicentre trial in China. EClinicalMedicine. 2022 Aug 12;52:101616. doi: 10.1016/j.eclinm.2022.101616. (IF = 15.1) 
  2. Liu H, Li J, Hu Y, Guo J, Lou T, Luo G, Chen S, Wang W, Ruan H, Sun Z, Fan C. Association Between Tranexamic Acid Use and Heterotopic Ossification Prevalence After Elbow Trauma Surgery: A Propensity-Score-Matched Cohort Study. J Bone Joint Surg Am. 2023 Jul 19;105(14):1093-1100. doi: 10.2106/JBJS.22.01212. (Official publication of American Orthopaedic Association)
  3. Xu Y, Xiong H, Liu W, Liu H, Guo J, Wang W, Ruan H, Sun Z, Fan C. Development and Validation of a Deep-Learning Model to Predict Total Hip Replacement on Radiographs: The Total Hip Replacement Prediction (THREP) Model. J Bone Joint Surg Am. 2024 Mar 6;106(5):389-396. doi: 10.2106/JBJS.23.00549. (Official publication of American Orthopaedic Association)
  4. Sun Z, Li J, Luo G, Wang F, Hu Y, Fan C. What constitutes a clinically important change in Mayo Elbow Performance Index and range of movement after open elbow arthrolysis? Bone Joint J. 2021 Feb;103-B(2):366-372. doi: 10.1302/0301-620X.103B2.BJJ-2020-0259.R3. (Official publication of British Orthopaedic Association)
  5. Li J, Liu H, Hu Y, Liu W, Wang W, Tu B, Cui H, Ruan H, Sun Z, Fan C. Surgical resection outcomes of post-traumatic elbow heterotopic ossification: multicenter case series at a minimum 5-year follow-up. Plast Reconstr Surg. 2023 Sep 20. doi: 10.1097/PRS.0000000000011077. (Official publication of American Plastic Association)
  • 12/01/2021-11/30/2026
    National Key Research and Development Project, ¥4,500,000,0 2021YFC2400800
    Development and application of biomimetic peripheral nerve graft products
    Role: Project leader
  • 01/01/2024-12/31/2028
    National Natural Science Foundation of China (Key Program), ¥2,930,000, 82330076
    The effects and mechanism of macrophage pyroptosis on the induction of aberrant differentiation of tendon-derived stem cells during traumatic heterotopic ossification formation
    Role: Principal Investigator
  • 01/01/2019-12/31/2023
    National Natural Science Foundation of China (Key Program), ¥2,400,000, 81830076
    Macrophage polarization induces the balance between osteogenesis and osteoclasis and promotes the traumatic heterotopic ossification
    Role: Principal Investigator
  1. [Fan Cunyi, Liu Shen, Wang Wei, Yu Shiyang, Li Zhiwei] (2018), Invention patent, “An artificial elbow joint surface replacement prosthesis”, ZL201610142857.6
  2. [Fan Cunyi, Wang Chunyang, Liu Junjian] (2015), Invention patent, “Oriented nanofiber bionic neural catheter and its fabrication
  3. Method of formulation”, ZL201010595866.3
  4. [Fan Cunyi, Wang Wei, Liu Shen, Li Yuanchao] (2016), Invention patent, “The invention relates to a simple elbow joint biomechanical experimental device”, ZL201410411644.X
  5. [Fan Cunyi, Liu Shen, Jin Fangchun, Lu Jianxi] (2014), Invention patent, “Cavity type dynamic perfusion biological response device”, ZL201110382573.1
  • Second prize of "National Science and Technology Progress Award" (First position, 2020)
  • First prize of "Shanghai Technology Invention Award" (First position, 2023) 
  • First prize of "Shanghai Science and Technology Progress Award" (First position, 2014)