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DU Yan  

  • Associate Chief Technician, Graduate Supervisor
  • Department: Laboratory Medicine
  • Research Area: Clinical Diagnostics
  • Research Interests: Tumor lymphangiogenesis and tumor lymphatic metastasis
  • Contact: du_yang@sjtu.edu.cn
Biography Positions Publications Research Projects
  • Associate chief technician, Department of Clinical Laboratory, Shanghai Sixth People's Hospital, 2018-12 to present 
  • Technologist-in-charge, Department of Clinical Laboratory, Shanghai Sixth People's Hospital, 2017-12~2018-12  
  • Visiting scholar, University of Miami, Miller School of Medicine, 2016-12~2017-12                                      
  • Technologist-in-charge, Department of Clinical Laboratory, Shanghai Sixth People's Hospital, 2015-07~2016-12
  • Technician, Department of Clinical Laboratory, Shanghai Sixth People's Hospital, 2013-07~2015-06 
  • Research Assistant, Department of Clinical Laboratory, Shanghai Sixth People's Hospital, 2011-07~2013-06
  • PhD from Shanghai Jiao Tong University School of Medicine, 2006-09~2011-06
  • Youth committee, Shanghai Anti-cancer Association Laboratory Medicine Professional Committee
  1. Si Chen*; Guoliang Zhang*; Yiwen Liu; Cuixia Yang; Yiqing He; Qian Guo; Yan Du#; Feng Gao#. Anchoring of hyaluronan glycocalyx to CD44 reduces sensitivity of HER2‐positive gastric cancercells to trastuzumab, The FEBS Journal, 2024. doi: 10.1111/febs.17069.  
  2.  Qiu Y*, Wang H*, Guo Q, Liu Y, He Y, Zhang G, Yang C, Du Y#, Gao F#. CD44s-activated tPA/LRP1-NFκB pathway drives lamellipodia outgrowth in luminal-type breast cancer cells; Front Cell Dev Biol, 2023 Sep 28;11:1224827. doi: 10.3389/fcell.2023.1224827.   
  3. Yan Du*; Manlin Cao*; Yiwen Liu; Yiqing He; Cuixia Yang; Guoliang Zhang; Youben Fan#; Feng Gao#. Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis, The FASEB Journal, 2022, 36(4): e22248. doi: 10.1096/fj.202101230R.                                
  4. Yan Du*; Hongwei Shao*; Mecker Moller; Rochelle Prokupets; Yee Ting Tse; Zhao-Jun Liu#. Intracellular Notch1 Signaling in Cancer-associated Fibroblasts dictates the plasticity and stemness of melanoma stem/initiating cells, Stem Cells, 2019, 37(7): 865-875.doi: 10.1002/stem.3013.                
  5. Boke Zhang*; Yan Du*; Yiqing He; Yiwen Liu; Guoliang Zhang; Cuixia Yang; Feng Gao#. INT-HA induces M2-like macrophage differentiation of human monocytes via TLR4-miR-935 pathway, Cancer Immunol Immunother, 2019, 68(2): 189-200.doi: 10.1007/s00262-018-2261-6. 
  6. Yan Du*; Manlin Cao*; Yiwen Liu; Yiqing He; Cuixia Yang; Man Wu; Guoliang Zhang; Feng Gao. Low-molecular-weight hyaluronan (LMW-HA) accelerates lymph node metastasis of melanoma cells by inducing disruption of lymphatic intercellular adhesion.OncoImmunology, 2016, 5(11):e1232235. doi: 10.1080/2162402X.2016.1232235.                                   
  7. Wu M*, Du Y*, Liu Y, He Y, Yang C, Wang W, Gao F.Low molecular weight hyaluronan induces lymphangiogenesis through LYVE-1-mediated signaling pathways.PLoS One.2014, 9(3):e92857.doi: 10.1371/journal.pone.0092857.                                           
  8. Du Y*, Liu H*, He YQ, Liu YW, Yang CX, Zhou MU, Wang WJ, Cui L, Hu JJ, Gao F. Binding of LYVE-1 with hyaluronan on the cell surface may play a role in the diverse adhesion to cancer cells. PLoS One.2013, 8(5):e63463.doi: 10.1371/journal.pone.0063463.         
  9. Muqing Zhou*, Yan Du*, Yiwen Liu, Yingzhi Wang, Yiqing He, Cuixia Yang, Wenjuan Wang, Feng Gao*. Clinical and experimental studies regarding the expression and diagnostic value of carcinoembryonic antigen-related cell adhesion molecule 1 in non-small-cell lung cancer. BMC Cancer.2013, 25;13:359.doi: 10.1186/1471-2407-13-359. 
  10. Du Y, Liu Y, Wang Y, He Y, Yang C, Gao F. LYVE-1 enhances the adhesion of HS-578T cells to COS-7 cells via hyaluronan. Clin Invest Med. 2011 Feb 1;34(1):E45-54. doi: 10.25011/cim.v34i1.14912.  
  • 01/01/2020-12/31/2023
    National Natural Science Foundation of China, ¥550,000, 81974446
    The role and mechanism of MD-LELCs induced by tumor microenvironment remodeling in tumor lymphatic vessel budding.
    Role: Project leader                                                          
  • 11/01/2019-10/31/2021
    Shanghai Pujiang Talent Plan, ¥300,000, 2019PJD037
    The role and mechanism of lymphoendothelioid cells derived from macrophages in lymphatic angiogenesis in tumors
    Role: Project leader
  • 01/01/2016-12/31/2018
    National Natural Science Foundation of China, ¥204,000, 81502490
    Study on the role and mechanism of oHA-LYVE1-S1P3 pathway in regulating the pore changes of lymphatic endothelial cells in tumor lymphatic metastasis
    Role: Project leader                                                                                                                                                                                                                     
  • 07/01/2014-6/30/2017  
  • Shanghai Young Science and Technology Talents Sailing program, ¥100,000, 14YF1412200                                
  • The role and mechanism of LYVE-1 in regulating the change of lymphoendothelial cell barrier function in tumor microenvironment                                   
  • Role: Project leader                                                                                                                                                                                                                                                                                                                                                                               

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